Macular edema in Wyburn-Mason syndrome: Resolution with anti-VEGF intravitreal injections. Case report and review of the literature
Purpose: Macular edema is an infrequent complication of retinal arteriovenous malformations. We present the management of unilateral macular edema with Bevacizumab 1.25mg/0.05mL and Aflibercept 2mg/0.05mL in a 16-year-old child with Wyburn-Mason syndrome. Observations: The patient developed macular...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
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| Series: | American Journal of Ophthalmology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451993624002196 |
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| Summary: | Purpose: Macular edema is an infrequent complication of retinal arteriovenous malformations. We present the management of unilateral macular edema with Bevacizumab 1.25mg/0.05mL and Aflibercept 2mg/0.05mL in a 16-year-old child with Wyburn-Mason syndrome. Observations: The patient developed macular edema after 15 years of unremarkable ophthalmological follow-up. After a one-month observation period, a first intravitreal injection of Bevacizumab 1.25mg/0.05mL, the treatment most frequently described in the literature, was found to be insufficient to reduce the macular edema.After the switch to Aflibercept 2.0mg/0.05mL, a significant reduction in macular edema was observed after three monthly intravitreal injections. This effect was prolonged over the 15-month observation follow-up. Conclusions and importance: Aflibercept 2mg/0.05mL may be a safe and effective option to manage macular edema complications in retinal arteriovenous malformations. |
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| ISSN: | 2451-9936 |