Immunogenicity of red blood cell blood group antigens in the population of Xi'an
[Objective] To evaluate the immunogenicity of red blood cell blood group antigens in the population of Xi'an. [Methods] Data on blood group antigens of voluntary blood donors from the Shaanxi Province Blood Center and unexpected antibody detection results from clinically submitted cases between...
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| Format: | Article |
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Institute of Blood Transfusion of Chinese Academy of Medical Sciences
2024-12-01
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| Series: | Zhongguo shuxue zazhi |
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| Online Access: | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2024.12.009&lang=en |
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| author | ZHANG Liangzi ZUO Qinqin XU Hua ZHANG Yong WU Dazhou TIAN Xue CHU Xiaoyue |
| author_facet | ZHANG Liangzi ZUO Qinqin XU Hua ZHANG Yong WU Dazhou TIAN Xue CHU Xiaoyue |
| author_sort | ZHANG Liangzi |
| collection | DOAJ |
| description | [Objective] To evaluate the immunogenicity of red blood cell blood group antigens in the population of Xi'an. [Methods] Data on blood group antigens of voluntary blood donors from the Shaanxi Province Blood Center and unexpected antibody detection results from clinically submitted cases between January 2019 and May 2024 were analyzed. The Giblett blood group antigen immunogenicity calculation formula was used to calculate the immunogenicity of blood group antigens based on the frequency of unexpected antibodies and the probability of antigen-negative patients receiving antigen-positive red blood cells. The relative immunogenicity of each blood group antigen was obtained by multiplying the immunogenicity of the K antigen (0.095). [Results] A total of 30 921 individuals were included for red blood cell blood group antigen analysis, with 511 cases of unexpected antibody identification. The ranking of red blood cell blood group antigen immunogenicity for the overall population was: Wra>E>Dib>Fya>K>C>e>c>Dia>Jka>M>Lea>Jkb>Leb>Fyb>S, while for males, it was: Dib>Wra>E>K>Fya>C>e>c>M>Dia>Jka>Fyb>Lea>Leb>Jkb>S. [Conclusion] Based on the immunogenicity ranking from strong to weak of red blood cell antigens in the population of Xi'an, this study provides theoretical support for the expansion and matching of antigens, and technical support for achieving precise red blood cell transfusions to improve transfusion efficacy and safety. |
| format | Article |
| id | doaj-art-fbb4253cd2d04b4e9108ee5f1ec7176e |
| institution | Kabale University |
| issn | 1004-549X |
| language | zho |
| publishDate | 2024-12-01 |
| publisher | Institute of Blood Transfusion of Chinese Academy of Medical Sciences |
| record_format | Article |
| series | Zhongguo shuxue zazhi |
| spelling | doaj-art-fbb4253cd2d04b4e9108ee5f1ec7176e2025-01-06T09:43:02ZzhoInstitute of Blood Transfusion of Chinese Academy of Medical SciencesZhongguo shuxue zazhi1004-549X2024-12-0137121394139810.13303/j.cjbt.issn.1004-549x.2024.12.0091004-549X(2024)12-1394-05Immunogenicity of red blood cell blood group antigens in the population of Xi'anZHANG Liangzi0ZUO Qinqin1XU Hua2ZHANG Yong3WU Dazhou4TIAN Xue5CHU Xiaoyue6Blood Center of Shaanxi Province, Xi'an 710061, ChinaBlood Center of Shaanxi Province, Xi'an 710061, ChinaBlood Center of Shaanxi Province, Xi'an 710061, ChinaBlood Center of Shaanxi Province, Xi'an 710061, ChinaBlood Center of Shaanxi Province, Xi'an 710061, ChinaBlood Center of Shaanxi Province, Xi'an 710061, ChinaBlood Center of Shaanxi Province, Xi'an 710061, China[Objective] To evaluate the immunogenicity of red blood cell blood group antigens in the population of Xi'an. [Methods] Data on blood group antigens of voluntary blood donors from the Shaanxi Province Blood Center and unexpected antibody detection results from clinically submitted cases between January 2019 and May 2024 were analyzed. The Giblett blood group antigen immunogenicity calculation formula was used to calculate the immunogenicity of blood group antigens based on the frequency of unexpected antibodies and the probability of antigen-negative patients receiving antigen-positive red blood cells. The relative immunogenicity of each blood group antigen was obtained by multiplying the immunogenicity of the K antigen (0.095). [Results] A total of 30 921 individuals were included for red blood cell blood group antigen analysis, with 511 cases of unexpected antibody identification. The ranking of red blood cell blood group antigen immunogenicity for the overall population was: Wra>E>Dib>Fya>K>C>e>c>Dia>Jka>M>Lea>Jkb>Leb>Fyb>S, while for males, it was: Dib>Wra>E>K>Fya>C>e>c>M>Dia>Jka>Fyb>Lea>Leb>Jkb>S. [Conclusion] Based on the immunogenicity ranking from strong to weak of red blood cell antigens in the population of Xi'an, this study provides theoretical support for the expansion and matching of antigens, and technical support for achieving precise red blood cell transfusions to improve transfusion efficacy and safety.https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2024.12.009&lang=enimmunogenicityalloimmunizationblood groupstransfusion medicine |
| spellingShingle | ZHANG Liangzi ZUO Qinqin XU Hua ZHANG Yong WU Dazhou TIAN Xue CHU Xiaoyue Immunogenicity of red blood cell blood group antigens in the population of Xi'an Zhongguo shuxue zazhi immunogenicity alloimmunization blood groups transfusion medicine |
| title | Immunogenicity of red blood cell blood group antigens in the population of Xi'an |
| title_full | Immunogenicity of red blood cell blood group antigens in the population of Xi'an |
| title_fullStr | Immunogenicity of red blood cell blood group antigens in the population of Xi'an |
| title_full_unstemmed | Immunogenicity of red blood cell blood group antigens in the population of Xi'an |
| title_short | Immunogenicity of red blood cell blood group antigens in the population of Xi'an |
| title_sort | immunogenicity of red blood cell blood group antigens in the population of xi an |
| topic | immunogenicity alloimmunization blood groups transfusion medicine |
| url | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2024.12.009&lang=en |
| work_keys_str_mv | AT zhangliangzi immunogenicityofredbloodcellbloodgroupantigensinthepopulationofxian AT zuoqinqin immunogenicityofredbloodcellbloodgroupantigensinthepopulationofxian AT xuhua immunogenicityofredbloodcellbloodgroupantigensinthepopulationofxian AT zhangyong immunogenicityofredbloodcellbloodgroupantigensinthepopulationofxian AT wudazhou immunogenicityofredbloodcellbloodgroupantigensinthepopulationofxian AT tianxue immunogenicityofredbloodcellbloodgroupantigensinthepopulationofxian AT chuxiaoyue immunogenicityofredbloodcellbloodgroupantigensinthepopulationofxian |