DARPins as a novel tool to detect and degrade p73

DARPins as a novel tool to detect and degrade p73

Abstract The concept of Targeted Protein Degradation (TPD) has been introduced as an attractive alternative to the development of classical inhibitors. TPD can extend the range of proteins that can be pharmacologically targeted beyond the classical targets for small molecule inhibitors, as a binding...

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Main Authors: Philipp Münick, Jasmin Zielinski, Alexander Strubel, Niklas Gutfreund, Birgit Dreier, Jonas V. Schaefer, Birgit Schäfer, Jakob Gebel, Christian Osterburg, Apirat Chaikuad, Stefan Knapp, Andreas Plückthun, Volker Dötsch
Format: Article
Language:English
Published: Nature Publishing Group 2024-12-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-07304-2
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https://doi.org/10.1038/s41419-024-07304-2

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