Prognosis, Controversies and Assessment of Bone Erosion or Invasion of Oral Squamous Cell Carcinoma
<b>Objectives</b>: To discuss the prognostic outcomes, controversies and assessment of bone erosion or invasion of oral squamous cell carcinoma (OSCC). <b>Methods:</b> A structured literature review was conducted to critically analyse relevant evidence. The Web of Science dat...
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MDPI AG
2025-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/15/1/104 |
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| author | Ahmed Ata Alfurhud |
| author_facet | Ahmed Ata Alfurhud |
| author_sort | Ahmed Ata Alfurhud |
| collection | DOAJ |
| description | <b>Objectives</b>: To discuss the prognostic outcomes, controversies and assessment of bone erosion or invasion of oral squamous cell carcinoma (OSCC). <b>Methods:</b> A structured literature review was conducted to critically analyse relevant evidence. The Web of Science database was searched using specific keywords aligned with the review question. After identifying initial studies, their references were also reviewed to include any additional relevant publications, ensuring a comprehensive evaluation of the available evidence. <b>Results:</b> The search identified 11 relevant studies, including 5 from the initial search and 6 from reference review. The significance of bone involvement is unclear in OSCC, with varying definitions of cortical bone erosion and medullary bone infiltration contributing to conflicting results regarding the prognostic significance of bone involvement. The majority of evidence stems from retrospective cohort studies without clear study criteria and a lack of power to draw valid conclusions. <b>Conclusions:</b> There are currently a lack of high-quality studies assessing bone invasion in OSCC. While there appears to be some evidence that medullary bone infiltration is prognostic, further well-designed studies are warranted. |
| format | Article |
| id | doaj-art-fb7b60fe3ca94798ae211df205079398 |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-fb7b60fe3ca94798ae211df2050793982025-01-10T13:16:44ZengMDPI AGDiagnostics2075-44182025-01-0115110410.3390/diagnostics15010104Prognosis, Controversies and Assessment of Bone Erosion or Invasion of Oral Squamous Cell CarcinomaAhmed Ata Alfurhud0Oral and Maxillofacial Surgery and Diagnostic Sciences Department, College of Dentistry, Jouf University, King Khalid Road, Sakaka 72388, Saudi Arabia<b>Objectives</b>: To discuss the prognostic outcomes, controversies and assessment of bone erosion or invasion of oral squamous cell carcinoma (OSCC). <b>Methods:</b> A structured literature review was conducted to critically analyse relevant evidence. The Web of Science database was searched using specific keywords aligned with the review question. After identifying initial studies, their references were also reviewed to include any additional relevant publications, ensuring a comprehensive evaluation of the available evidence. <b>Results:</b> The search identified 11 relevant studies, including 5 from the initial search and 6 from reference review. The significance of bone involvement is unclear in OSCC, with varying definitions of cortical bone erosion and medullary bone infiltration contributing to conflicting results regarding the prognostic significance of bone involvement. The majority of evidence stems from retrospective cohort studies without clear study criteria and a lack of power to draw valid conclusions. <b>Conclusions:</b> There are currently a lack of high-quality studies assessing bone invasion in OSCC. While there appears to be some evidence that medullary bone infiltration is prognostic, further well-designed studies are warranted.https://www.mdpi.com/2075-4418/15/1/104cortical bonemedullary carcinomasoral squamous cell carcinomaoutcomeprognosis |
| spellingShingle | Ahmed Ata Alfurhud Prognosis, Controversies and Assessment of Bone Erosion or Invasion of Oral Squamous Cell Carcinoma Diagnostics cortical bone medullary carcinomas oral squamous cell carcinoma outcome prognosis |
| title | Prognosis, Controversies and Assessment of Bone Erosion or Invasion of Oral Squamous Cell Carcinoma |
| title_full | Prognosis, Controversies and Assessment of Bone Erosion or Invasion of Oral Squamous Cell Carcinoma |
| title_fullStr | Prognosis, Controversies and Assessment of Bone Erosion or Invasion of Oral Squamous Cell Carcinoma |
| title_full_unstemmed | Prognosis, Controversies and Assessment of Bone Erosion or Invasion of Oral Squamous Cell Carcinoma |
| title_short | Prognosis, Controversies and Assessment of Bone Erosion or Invasion of Oral Squamous Cell Carcinoma |
| title_sort | prognosis controversies and assessment of bone erosion or invasion of oral squamous cell carcinoma |
| topic | cortical bone medullary carcinomas oral squamous cell carcinoma outcome prognosis |
| url | https://www.mdpi.com/2075-4418/15/1/104 |
| work_keys_str_mv | AT ahmedataalfurhud prognosiscontroversiesandassessmentofboneerosionorinvasionoforalsquamouscellcarcinoma |