HDAC6 inhibition by ITF3756 modulates PD-L1 expression and monocyte phenotype: insights for a promising immune checkpoint blockade co-treatment therapy

HDAC6 inhibition by ITF3756 modulates PD-L1 expression and monocyte phenotype: insights for a promising immune checkpoint blockade co-treatment therapy

IntroductionTumor immunotherapy has revolutionized cancer treatment, particularly through the use of immune checkpoint inhibitors targeting the PD-L1/PD-1 axis. While PD-L1 expression on tumor cells is an established predictive biomarker for therapeutic response, emerging evidence highlights the imp...

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Bibliographic Details
Main Authors: Valeria Spadotto, Chiara Ripamonti, Andrea Ghiroldi, Elisabetta Galbiati, Pietro Pozzi, Roberta Noberini, Tiziana Bonaldi, Christian Steinkühler, Gianluca Fossati
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
HDAC6
monocytes
immuno-checkpoints
TNF-α
dendritic cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1546939/full
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