Pericopsis laxiflora (Baker) stem bark extract is protective against carbon tetrachloride-induced acute liver damage by modulation of oxidative stress and inflammation
The present study aimed to investigate the hepatoprotective activity of the hydroethanolic (HSE) and methanolic extracts (MSE) of Pericopsis laxiflora stem bark on carbon tetrachloride-induced hepatotoxicity in rats. The stem bark of P. laxiflora was extracted with 50% ethanol and methanol. Hepatopr...
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Taylor & Francis Group
2024-12-01
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| Series: | Journal of Taibah University for Science |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/16583655.2024.2354569 |
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| author | Frederick Sarfo-Antwi Christopher Larbie Benjamin Obukowho Emikpe Regina Appiah–Opong |
| author_facet | Frederick Sarfo-Antwi Christopher Larbie Benjamin Obukowho Emikpe Regina Appiah–Opong |
| author_sort | Frederick Sarfo-Antwi |
| collection | DOAJ |
| description | The present study aimed to investigate the hepatoprotective activity of the hydroethanolic (HSE) and methanolic extracts (MSE) of Pericopsis laxiflora stem bark on carbon tetrachloride-induced hepatotoxicity in rats. The stem bark of P. laxiflora was extracted with 50% ethanol and methanol. Hepatoprotective activities were assessed using the CCl4 model and tested against extracts at 100, 250, and 500 mg/kg bwt. Biochemical, antioxidant enzymes and proinflammatory cytokines in liver homogenate were assayed. Treatment with HSE and MSE resulted in a significant increase in SOD, CAT, and GSH levels and a significant decrease in MDA and MPO levels in livers of CCl4 treated rats. There was also restoration of liver biomarkers and pro-inflammatory cytokines to near-normal levels. The present investigation suggests P. laxiflora extracts possess good hepatoprotective properties. This could be attributed in part to the inhibitory effect of the extracts on oxidative stress and the suppression of proinflammatory cytokines. |
| format | Article |
| id | doaj-art-fb502f177f2a4b11b0793a9ae2dec89e |
| institution | Kabale University |
| issn | 1658-3655 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Taibah University for Science |
| spelling | doaj-art-fb502f177f2a4b11b0793a9ae2dec89e2024-12-17T11:38:48ZengTaylor & Francis GroupJournal of Taibah University for Science1658-36552024-12-0118110.1080/16583655.2024.2354569Pericopsis laxiflora (Baker) stem bark extract is protective against carbon tetrachloride-induced acute liver damage by modulation of oxidative stress and inflammationFrederick Sarfo-Antwi0Christopher Larbie1Benjamin Obukowho Emikpe2Regina Appiah–Opong3Department of Biochemistry and Molecular Medicine, School of Medicine, University for Development Studies, Tamale, GhanaDepartment of Biochemistry and Biotechnology, College of Science, Kwame Nkrumah University of Science and Technology, Kumasi, GhanaDepartment of Veterinary Pathology, School of Veterinary Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, GhanaDepartment of Clinical Pathology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, GhanaThe present study aimed to investigate the hepatoprotective activity of the hydroethanolic (HSE) and methanolic extracts (MSE) of Pericopsis laxiflora stem bark on carbon tetrachloride-induced hepatotoxicity in rats. The stem bark of P. laxiflora was extracted with 50% ethanol and methanol. Hepatoprotective activities were assessed using the CCl4 model and tested against extracts at 100, 250, and 500 mg/kg bwt. Biochemical, antioxidant enzymes and proinflammatory cytokines in liver homogenate were assayed. Treatment with HSE and MSE resulted in a significant increase in SOD, CAT, and GSH levels and a significant decrease in MDA and MPO levels in livers of CCl4 treated rats. There was also restoration of liver biomarkers and pro-inflammatory cytokines to near-normal levels. The present investigation suggests P. laxiflora extracts possess good hepatoprotective properties. This could be attributed in part to the inhibitory effect of the extracts on oxidative stress and the suppression of proinflammatory cytokines.https://www.tandfonline.com/doi/10.1080/16583655.2024.2354569Biochemical parameterscarbon tetrachloridehepatoprotectivePericopsis laxiflora |
| spellingShingle | Frederick Sarfo-Antwi Christopher Larbie Benjamin Obukowho Emikpe Regina Appiah–Opong Pericopsis laxiflora (Baker) stem bark extract is protective against carbon tetrachloride-induced acute liver damage by modulation of oxidative stress and inflammation Journal of Taibah University for Science Biochemical parameters carbon tetrachloride hepatoprotective Pericopsis laxiflora |
| title | Pericopsis laxiflora (Baker) stem bark extract is protective against carbon tetrachloride-induced acute liver damage by modulation of oxidative stress and inflammation |
| title_full | Pericopsis laxiflora (Baker) stem bark extract is protective against carbon tetrachloride-induced acute liver damage by modulation of oxidative stress and inflammation |
| title_fullStr | Pericopsis laxiflora (Baker) stem bark extract is protective against carbon tetrachloride-induced acute liver damage by modulation of oxidative stress and inflammation |
| title_full_unstemmed | Pericopsis laxiflora (Baker) stem bark extract is protective against carbon tetrachloride-induced acute liver damage by modulation of oxidative stress and inflammation |
| title_short | Pericopsis laxiflora (Baker) stem bark extract is protective against carbon tetrachloride-induced acute liver damage by modulation of oxidative stress and inflammation |
| title_sort | pericopsis laxiflora baker stem bark extract is protective against carbon tetrachloride induced acute liver damage by modulation of oxidative stress and inflammation |
| topic | Biochemical parameters carbon tetrachloride hepatoprotective Pericopsis laxiflora |
| url | https://www.tandfonline.com/doi/10.1080/16583655.2024.2354569 |
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