Plasma Rich in Growth Factors Compared to Xenogenic Bone Graft in Treatment of Periodontal Intra-Osseous Defects—A Prospective, Comparative Clinical Study
Background: Periodontal intra-bony defects are challenging conditions in dental practice, often requiring regenerative approaches for successful treatment. This clinical study aimed to compare the effectiveness of plasma rich in growth factors (PRGF) versus xenogenic bone graft (BXG) in addressing i...
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2024-11-01
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| Series: | Journal of Functional Biomaterials |
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| author | Sourav Panda Sital Panda Abhaya Chandra Das Natalia Lewkowicz Barbara Lapinska Margherita Tumedei Funda Goker Niccolò Cenzato Massimo Del Fabbro |
| author_facet | Sourav Panda Sital Panda Abhaya Chandra Das Natalia Lewkowicz Barbara Lapinska Margherita Tumedei Funda Goker Niccolò Cenzato Massimo Del Fabbro |
| author_sort | Sourav Panda |
| collection | DOAJ |
| description | Background: Periodontal intra-bony defects are challenging conditions in dental practice, often requiring regenerative approaches for successful treatment. This clinical study aimed to compare the effectiveness of plasma rich in growth factors (PRGF) versus xenogenic bone graft (BXG) in addressing intra-bony defects. Methods: Forty patients aged between 30 and 50 years presenting with generalized periodontitis were included. The study assessed various parameters, including relative attachment level (RAL); probing pocket depth (PPD); gingival marginal level (GML); intra-bony defect depth (IBDD) at baseline, 3, and 6 months; and level of pain, post-operative bleeding, and swelling, as patient-reported outcomes during the first seven days post operation. Results: The results revealed that both PRGF and BXG treatments led to significant reductions in IBDD over the 6-month study period. PRGF demonstrated significant advantages in GML enhancement and post-operative pain management during the initial post-treatment days. However, BXG showed a significantly greater reduction in IBDD compared to PRGF. Post-operative bleeding and swelling levels were comparable between the two treatments. Conclusions: These findings underscore the efficacy of both PRGF and BXG in periodontal regeneration, with treatment decisions guided by patient-specific factors and clinical goals. |
| format | Article |
| id | doaj-art-fb41c74ae4fc46dba845badddc8db616 |
| institution | Kabale University |
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| language | English |
| publishDate | 2024-11-01 |
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| series | Journal of Functional Biomaterials |
| spelling | doaj-art-fb41c74ae4fc46dba845badddc8db6162024-11-26T18:07:32ZengMDPI AGJournal of Functional Biomaterials2079-49832024-11-01151133610.3390/jfb15110336Plasma Rich in Growth Factors Compared to Xenogenic Bone Graft in Treatment of Periodontal Intra-Osseous Defects—A Prospective, Comparative Clinical StudySourav Panda0Sital Panda1Abhaya Chandra Das2Natalia Lewkowicz3Barbara Lapinska4Margherita Tumedei5Funda Goker6Niccolò Cenzato7Massimo Del Fabbro8Department of Periodontics, Institute of Dental Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar 751002, Odisha, IndiaResearch Associate, Institute of Dental Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar 751002, Odisha, IndiaDepartment of Periodontics, Institute of Dental Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar 751002, Odisha, IndiaDepartment of Periodontology and Oral Diseases, Medical University of Lodz, 251 Pomorska St., 92-213 Lodz, PolandDepartment of General Dentistry, Medical University of Lodz, 251 Pomorska St., 92-213 Lodz, PolandDepartment of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, 20122 Milan, ItalyDepartment of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, 20122 Milan, ItalyDepartment of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, 20122 Milan, ItalyDepartment of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, 20122 Milan, ItalyBackground: Periodontal intra-bony defects are challenging conditions in dental practice, often requiring regenerative approaches for successful treatment. This clinical study aimed to compare the effectiveness of plasma rich in growth factors (PRGF) versus xenogenic bone graft (BXG) in addressing intra-bony defects. Methods: Forty patients aged between 30 and 50 years presenting with generalized periodontitis were included. The study assessed various parameters, including relative attachment level (RAL); probing pocket depth (PPD); gingival marginal level (GML); intra-bony defect depth (IBDD) at baseline, 3, and 6 months; and level of pain, post-operative bleeding, and swelling, as patient-reported outcomes during the first seven days post operation. Results: The results revealed that both PRGF and BXG treatments led to significant reductions in IBDD over the 6-month study period. PRGF demonstrated significant advantages in GML enhancement and post-operative pain management during the initial post-treatment days. However, BXG showed a significantly greater reduction in IBDD compared to PRGF. Post-operative bleeding and swelling levels were comparable between the two treatments. Conclusions: These findings underscore the efficacy of both PRGF and BXG in periodontal regeneration, with treatment decisions guided by patient-specific factors and clinical goals.https://www.mdpi.com/2079-4983/15/11/336intra-osseous defectsperiodontal regenerationplasma rich in growth factorsxenograft |
| spellingShingle | Sourav Panda Sital Panda Abhaya Chandra Das Natalia Lewkowicz Barbara Lapinska Margherita Tumedei Funda Goker Niccolò Cenzato Massimo Del Fabbro Plasma Rich in Growth Factors Compared to Xenogenic Bone Graft in Treatment of Periodontal Intra-Osseous Defects—A Prospective, Comparative Clinical Study Journal of Functional Biomaterials intra-osseous defects periodontal regeneration plasma rich in growth factors xenograft |
| title | Plasma Rich in Growth Factors Compared to Xenogenic Bone Graft in Treatment of Periodontal Intra-Osseous Defects—A Prospective, Comparative Clinical Study |
| title_full | Plasma Rich in Growth Factors Compared to Xenogenic Bone Graft in Treatment of Periodontal Intra-Osseous Defects—A Prospective, Comparative Clinical Study |
| title_fullStr | Plasma Rich in Growth Factors Compared to Xenogenic Bone Graft in Treatment of Periodontal Intra-Osseous Defects—A Prospective, Comparative Clinical Study |
| title_full_unstemmed | Plasma Rich in Growth Factors Compared to Xenogenic Bone Graft in Treatment of Periodontal Intra-Osseous Defects—A Prospective, Comparative Clinical Study |
| title_short | Plasma Rich in Growth Factors Compared to Xenogenic Bone Graft in Treatment of Periodontal Intra-Osseous Defects—A Prospective, Comparative Clinical Study |
| title_sort | plasma rich in growth factors compared to xenogenic bone graft in treatment of periodontal intra osseous defects a prospective comparative clinical study |
| topic | intra-osseous defects periodontal regeneration plasma rich in growth factors xenograft |
| url | https://www.mdpi.com/2079-4983/15/11/336 |
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