Attenuated Nuclear Tension Regulates Progerin‐Induced Mechanosensitive Nuclear Wrinkling and Chromatin Remodeling

Attenuated Nuclear Tension Regulates Progerin‐Induced Mechanosensitive Nuclear Wrinkling and Chromatin Remodeling

Abstract Hutchinson–Gilford progeria syndrome, caused by a mutation in the LMNA gene, leads to increased levels of truncated prelamin A, progerin, in the nuclear membrane. The accumulation of progerin results in defective nuclear morphology and is associated with altered expression of linker of the...

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Bibliographic Details
Main Authors: Ji‐Eun Park, Juhyeon Jo, Kun Xu, Sun‐Ah Lee, Seong‐Beom Han, YigJi Lee, Won‐Ki Cho, Bo Li, Soo Hyun Kim, Dong‐Hwee Kim
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Advanced Science
Subjects:
actomyosin contractility
chromatin remodeling
heterochromatin
Hutchinson–Gilford progeria syndrome
LINC complex
mechanosensation
Online Access:https://doi.org/10.1002/advs.202502375
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https://doi.org/10.1002/advs.202502375

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