Synthesis, Crystal Structures, Antimicrobial Activity, and Acute Toxicity Evaluation of Chiral Zn(II) Schiff Base Complexes
Four mononuclear bioefficient zinc coordination complexes [Zn(NN)<sub>3</sub>](ClO<sub>4</sub>)<sub>2</sub> (<b>A</b>–<b>D</b>) involving chiral bidentate Schiff base ligands have been synthesized and characterized by IR, <sup>1</s...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/29/23/5555 |
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| Summary: | Four mononuclear bioefficient zinc coordination complexes [Zn(NN)<sub>3</sub>](ClO<sub>4</sub>)<sub>2</sub> (<b>A</b>–<b>D</b>) involving chiral bidentate Schiff base ligands have been synthesized and characterized by IR, <sup>1</sup>H, and <sup>13</sup>C NMR spectroscopy and mass spectrometry. X-ray crystal structures of three of the zinc complexes revealed that the zinc metal ion is hexacoordinated, exhibiting a distorted octahedral geometry where both the nitrogen atoms (NN = pyridyl and imine) of imines are coordinated to the central zinc ion. The isolated zinc complexes were evaluated for their antimicrobial activity in vitro against <i>Escherichia coli</i>, <i>Pseudomonas aeruginosa</i>, and <i>Staphylococcus aureus</i>, displaying varying levels of growth inhibition. An acute toxicity test conducted using <i>Artemia salina</i> and Swiss albino mice showed that the zinc complexes <b>A</b>–<b>D</b> were non-toxic towards <i>A. salina</i> at concentrations below 414, 564, 350, and 385 µM, respectively, and did not affect liver biochemical parameters, although pyknosis was induced in hepatocytes of the treated mice. |
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| ISSN: | 1420-3049 |