Immunogenic properties of nickel-doped maghemite nanoparticles and the implication for cancer immunotherapy
Nanoparticles are commonly used in diagnostics and therapy. They are also increasingly being implemented in cancer immunotherapy because of their ability to deliver drugs and modulate the immune system. However, the effect of nanoparticles on immune cells involved in the anti-tumor immune response i...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Journal of Immunotoxicology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/1547691X.2024.2416988 |
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| author | Lenka Rajsiglova Michal Babic Katerina Krausova Pavol Lukac Katerina Kalkusova Pavla Taborska Ludek Sojka Jirina Bartunkova Dmitry Stakheev Luca Vannucci Daniel Smrz |
| author_facet | Lenka Rajsiglova Michal Babic Katerina Krausova Pavol Lukac Katerina Kalkusova Pavla Taborska Ludek Sojka Jirina Bartunkova Dmitry Stakheev Luca Vannucci Daniel Smrz |
| author_sort | Lenka Rajsiglova |
| collection | DOAJ |
| description | Nanoparticles are commonly used in diagnostics and therapy. They are also increasingly being implemented in cancer immunotherapy because of their ability to deliver drugs and modulate the immune system. However, the effect of nanoparticles on immune cells involved in the anti-tumor immune response is not well understood. The study reported here showed that nickel-doped maghemite nanoparticles (FN NP) are differentially cytotoxic to cultured mouse and human cancer cell lines, causing their death without negatively impacting the subsequent anticancer immune response. It also found that FN NP induced cell death in the mouse colorectal cancer cell line CT26 and human prostate cancer cell line PC-3, but not in the human prostate cancer cell line LNCaP. The induced cancer cell death did not affect the phenotype and responsivity of the isolated mouse peritoneal macrophages, or ex vivo-generated mouse bone marrow-derived, or human monocyte-derived dendritic cells. Additionally, the induced cancer cell death did not prevent the ex vivo-generated mouse or human dendritic cells from stimulating lymphocytes and enriching cell cultures with cancer cell-reactive T-cells. In conclusion, this study shows that FN NP could be a valuable platform for targeting cancer cells without causing immunosuppressive effects on the subsequent anticancer immune response. |
| format | Article |
| id | doaj-art-faad2b3f2a964152a6f8f1f3a094e31d |
| institution | Kabale University |
| issn | 1547-691X 1547-6901 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Immunotoxicology |
| spelling | doaj-art-faad2b3f2a964152a6f8f1f3a094e31d2025-01-17T12:52:14ZengTaylor & Francis GroupJournal of Immunotoxicology1547-691X1547-69012024-12-0121110.1080/1547691X.2024.2416988Immunogenic properties of nickel-doped maghemite nanoparticles and the implication for cancer immunotherapyLenka Rajsiglova0Michal Babic1Katerina Krausova2Pavol Lukac3Katerina Kalkusova4Pavla Taborska5Ludek Sojka6Jirina Bartunkova7Dmitry Stakheev8Luca Vannucci9Daniel Smrz10Laboratory of Immunotherapy, Institute of Microbiology of the Czech Academy of Sciences, v.v.i, Prague, Czech RepublicInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Prague, Czech RepublicLaboratory of Immunotherapy, Institute of Microbiology of the Czech Academy of Sciences, v.v.i, Prague, Czech RepublicLaboratory of Immunotherapy, Institute of Microbiology of the Czech Academy of Sciences, v.v.i, Prague, Czech RepublicDepartment of Immunology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech RepublicDepartment of Immunology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech RepublicDepartment of Immunology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech RepublicDepartment of Immunology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech RepublicLaboratory of Immunotherapy, Institute of Microbiology of the Czech Academy of Sciences, v.v.i, Prague, Czech RepublicLaboratory of Immunotherapy, Institute of Microbiology of the Czech Academy of Sciences, v.v.i, Prague, Czech RepublicLaboratory of Immunotherapy, Institute of Microbiology of the Czech Academy of Sciences, v.v.i, Prague, Czech RepublicNanoparticles are commonly used in diagnostics and therapy. They are also increasingly being implemented in cancer immunotherapy because of their ability to deliver drugs and modulate the immune system. However, the effect of nanoparticles on immune cells involved in the anti-tumor immune response is not well understood. The study reported here showed that nickel-doped maghemite nanoparticles (FN NP) are differentially cytotoxic to cultured mouse and human cancer cell lines, causing their death without negatively impacting the subsequent anticancer immune response. It also found that FN NP induced cell death in the mouse colorectal cancer cell line CT26 and human prostate cancer cell line PC-3, but not in the human prostate cancer cell line LNCaP. The induced cancer cell death did not affect the phenotype and responsivity of the isolated mouse peritoneal macrophages, or ex vivo-generated mouse bone marrow-derived, or human monocyte-derived dendritic cells. Additionally, the induced cancer cell death did not prevent the ex vivo-generated mouse or human dendritic cells from stimulating lymphocytes and enriching cell cultures with cancer cell-reactive T-cells. In conclusion, this study shows that FN NP could be a valuable platform for targeting cancer cells without causing immunosuppressive effects on the subsequent anticancer immune response.https://www.tandfonline.com/doi/10.1080/1547691X.2024.2416988Nanoparticlescancer cellsimmunogenic cell deathmacrophagesdendritic cellsT-cells |
| spellingShingle | Lenka Rajsiglova Michal Babic Katerina Krausova Pavol Lukac Katerina Kalkusova Pavla Taborska Ludek Sojka Jirina Bartunkova Dmitry Stakheev Luca Vannucci Daniel Smrz Immunogenic properties of nickel-doped maghemite nanoparticles and the implication for cancer immunotherapy Journal of Immunotoxicology Nanoparticles cancer cells immunogenic cell death macrophages dendritic cells T-cells |
| title | Immunogenic properties of nickel-doped maghemite nanoparticles and the implication for cancer immunotherapy |
| title_full | Immunogenic properties of nickel-doped maghemite nanoparticles and the implication for cancer immunotherapy |
| title_fullStr | Immunogenic properties of nickel-doped maghemite nanoparticles and the implication for cancer immunotherapy |
| title_full_unstemmed | Immunogenic properties of nickel-doped maghemite nanoparticles and the implication for cancer immunotherapy |
| title_short | Immunogenic properties of nickel-doped maghemite nanoparticles and the implication for cancer immunotherapy |
| title_sort | immunogenic properties of nickel doped maghemite nanoparticles and the implication for cancer immunotherapy |
| topic | Nanoparticles cancer cells immunogenic cell death macrophages dendritic cells T-cells |
| url | https://www.tandfonline.com/doi/10.1080/1547691X.2024.2416988 |
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