Screening for retinopathy of prematurity in China: a five-year cohort study in seven screening centers
Abstract Background To analyze the demographic characteristics of retinopathy of prematurity (ROP) in China, attempting to propose optimized screening criteria and hopefully providing valuable information for future updates to the ROP guideline. Methods A multicenter, retrospective-cohort study was...
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2025-01-01
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| author | Yusheng Zhong Xiacheng Lin Yating Yang Liying He Na Li Jun Lu Yu Zhou Rong Zhang Yacong Wang Zhongyu Zhang Mochi Yang Hong Yin Mingwei Zhao Xiaoxin Li Jianhong Liang Yong Cheng |
| author_facet | Yusheng Zhong Xiacheng Lin Yating Yang Liying He Na Li Jun Lu Yu Zhou Rong Zhang Yacong Wang Zhongyu Zhang Mochi Yang Hong Yin Mingwei Zhao Xiaoxin Li Jianhong Liang Yong Cheng |
| author_sort | Yusheng Zhong |
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| description | Abstract Background To analyze the demographic characteristics of retinopathy of prematurity (ROP) in China, attempting to propose optimized screening criteria and hopefully providing valuable information for future updates to the ROP guideline. Methods A multicenter, retrospective-cohort study was conducted. The study included infants born between January 1, 2018, and July 31, 2023, who underwent ROP screening and were diagnosed with ROP at seven screening centers in China. Examinations were carried out in accordance with the ROP guidelines in 2014: infants with a gestational age (GA)<32 weeks and/or birth weight (BW)<2000 g, or infants who were suspected to be at risk of ROP. ROP treatment followed the recommendations of the Early Treatment for Retinopathy of Prematurity Cooperative Group. We utilized receiver operating characteristic (ROC) curves to determine the optimal predictive model, and conducted internal validation as well as compared the model to current standards. Results Among the 4770 infants diagnosed with ROP after fundus screening, 1330 (27.9%) infants received treatment. The mean GA at birth for all enrolled infants was 29.67 ± 2.45 weeks, with a mean BW of 1295.89 ± 403.64 g. This study proposed the optimization of guidelines to be ≤ 30 weeks of GA and ≤ 1600 g of BW, achieving a sensitivity of 99.4%, as high as the current standard, with an 18.0% reduction in screening requirements. Conclusion Considering the decrease in both GA and BW among the population requiring ROP treatment in China, it is imperative to contemplate updating the ROP screening guideline. |
| format | Article |
| id | doaj-art-fa86b5b139c044e28a4d6868d5509fb4 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Ophthalmology |
| spelling | doaj-art-fa86b5b139c044e28a4d6868d5509fb42025-01-05T12:11:50ZengBMCBMC Ophthalmology1471-24152025-01-012511810.1186/s12886-024-03836-5Screening for retinopathy of prematurity in China: a five-year cohort study in seven screening centersYusheng Zhong0Xiacheng Lin1Yating Yang2Liying He3Na Li4Jun Lu5Yu Zhou6Rong Zhang7Yacong Wang8Zhongyu Zhang9Mochi Yang10Hong Yin11Mingwei Zhao12Xiaoxin Li13Jianhong Liang14Yong Cheng15Department of Ophthalmology, Peking University People’s Hospital, Beijing Key Laboratory of Ocular Disease and Optometry ScienceDepartment of Ophthalmology, Peking University People’s Hospital, Beijing Key Laboratory of Ocular Disease and Optometry ScienceDepartment of Ophthalmology, Peking University People’s Hospital, Beijing Key Laboratory of Ocular Disease and Optometry ScienceWomen and Children’s Hospital of Chongqing Medical UniversityKunming Maternity and Child Care HospitalKunming Maternity and Child Care HospitalMaternal and Child Health Hospital of GuangxiThe Fourth Hospital of ShijiazhuangThe Fourth Hospital of ShijiazhuangDepartment of Ophthalmology, The Second Affiliated Hospital of Harbin Medical UniversityGeneral Hospital of Ningxia Medical UniversityDepartment of Ophthalmology, Peking University People’s Hospital, Beijing Key Laboratory of Ocular Disease and Optometry ScienceDepartment of Ophthalmology, Peking University People’s Hospital, Beijing Key Laboratory of Ocular Disease and Optometry ScienceDepartment of Ophthalmology, Peking University People’s Hospital, Beijing Key Laboratory of Ocular Disease and Optometry ScienceDepartment of Ophthalmology, Peking University People’s Hospital, Beijing Key Laboratory of Ocular Disease and Optometry ScienceDepartment of Ophthalmology, Peking University People’s Hospital, Beijing Key Laboratory of Ocular Disease and Optometry ScienceAbstract Background To analyze the demographic characteristics of retinopathy of prematurity (ROP) in China, attempting to propose optimized screening criteria and hopefully providing valuable information for future updates to the ROP guideline. Methods A multicenter, retrospective-cohort study was conducted. The study included infants born between January 1, 2018, and July 31, 2023, who underwent ROP screening and were diagnosed with ROP at seven screening centers in China. Examinations were carried out in accordance with the ROP guidelines in 2014: infants with a gestational age (GA)<32 weeks and/or birth weight (BW)<2000 g, or infants who were suspected to be at risk of ROP. ROP treatment followed the recommendations of the Early Treatment for Retinopathy of Prematurity Cooperative Group. We utilized receiver operating characteristic (ROC) curves to determine the optimal predictive model, and conducted internal validation as well as compared the model to current standards. Results Among the 4770 infants diagnosed with ROP after fundus screening, 1330 (27.9%) infants received treatment. The mean GA at birth for all enrolled infants was 29.67 ± 2.45 weeks, with a mean BW of 1295.89 ± 403.64 g. This study proposed the optimization of guidelines to be ≤ 30 weeks of GA and ≤ 1600 g of BW, achieving a sensitivity of 99.4%, as high as the current standard, with an 18.0% reduction in screening requirements. Conclusion Considering the decrease in both GA and BW among the population requiring ROP treatment in China, it is imperative to contemplate updating the ROP screening guideline.https://doi.org/10.1186/s12886-024-03836-5Retinopathy of prematurityScreening criteriaChina |
| spellingShingle | Yusheng Zhong Xiacheng Lin Yating Yang Liying He Na Li Jun Lu Yu Zhou Rong Zhang Yacong Wang Zhongyu Zhang Mochi Yang Hong Yin Mingwei Zhao Xiaoxin Li Jianhong Liang Yong Cheng Screening for retinopathy of prematurity in China: a five-year cohort study in seven screening centers BMC Ophthalmology Retinopathy of prematurity Screening criteria China |
| title | Screening for retinopathy of prematurity in China: a five-year cohort study in seven screening centers |
| title_full | Screening for retinopathy of prematurity in China: a five-year cohort study in seven screening centers |
| title_fullStr | Screening for retinopathy of prematurity in China: a five-year cohort study in seven screening centers |
| title_full_unstemmed | Screening for retinopathy of prematurity in China: a five-year cohort study in seven screening centers |
| title_short | Screening for retinopathy of prematurity in China: a five-year cohort study in seven screening centers |
| title_sort | screening for retinopathy of prematurity in china a five year cohort study in seven screening centers |
| topic | Retinopathy of prematurity Screening criteria China |
| url | https://doi.org/10.1186/s12886-024-03836-5 |
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