An esophageal stent integrated with wireless battery-free movable photodynamic-therapy unit for targeted tumor treatment
Esophageal cancer is the eighth most common cancer worldwide and the sixth leading cause of cancer-related deaths. In this study, we propose a novel esophageal stent equipped with a wireless, battery-free, and movable photodynamic therapy (PDT) unit designed to treat esophageal tumors with flexibili...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424004551 |
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| author | Qian Han Pingjin Zou Xianhao Wei Junyang Chen Xiaojiao Li Li Quan Ranlin Wang Lili Xing Xinyu Xue Yi Zhou Meihua Chen |
| author_facet | Qian Han Pingjin Zou Xianhao Wei Junyang Chen Xiaojiao Li Li Quan Ranlin Wang Lili Xing Xinyu Xue Yi Zhou Meihua Chen |
| author_sort | Qian Han |
| collection | DOAJ |
| description | Esophageal cancer is the eighth most common cancer worldwide and the sixth leading cause of cancer-related deaths. In this study, we propose a novel esophageal stent equipped with a wireless, battery-free, and movable photodynamic therapy (PDT) unit designed to treat esophageal tumors with flexibility, precision, and real-time control. This system integrates a PDT unit and an electrochemical pneumatic soft actuator into a conventional esophageal stent. Each module incorporates a piezoelectric transducer capable of receiving external ultrasound to power the respective module. These transducers selectively respond to different external ultrasound frequencies, enabling independent operation without mutual interference. The therapy module provides a light source for PDT, inducing the production of cytotoxic reactive oxygen species (ROS) in tumor cells and promoting apoptosis. The pneumatic actuator based on electrochemical principles plays a critical role in controlling the position of the PDT light source, enabling the movement of the therapy module up to 200 mm within 15 min. This allows real-time control to maintain the light source near the tumor, ensuring precise and targeted treatment. The system can wirelessly and in real-time control the PDT light source's position via external ultrasound, offering a novel approach for treating esophageal cancer patients according to the need of tumor's progression. |
| format | Article |
| id | doaj-art-fa74622e37024b3084ba4b569d1df93c |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-fa74622e37024b3084ba4b569d1df93c2025-01-17T04:52:05ZengElsevierMaterials Today Bio2590-00642025-02-0130101394An esophageal stent integrated with wireless battery-free movable photodynamic-therapy unit for targeted tumor treatmentQian Han0Pingjin Zou1Xianhao Wei2Junyang Chen3Xiaojiao Li4Li Quan5Ranlin Wang6Lili Xing7Xinyu Xue8Yi Zhou9Meihua Chen10School of Physics, University of Electronic Science and Technology of China, Chengdu, 611731, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610054, ChinaDepartment of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, ChinaSchool of Physics, University of Electronic Science and Technology of China, Chengdu, 611731, ChinaDepartment of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, ChinaSchool of Physics, University of Electronic Science and Technology of China, Chengdu, 611731, ChinaChengdu University of Traditional Chinese Medicine, Chengdu, 610032, ChinaDepartment of Endoscopy, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, ChinaSchool of Physics, University of Electronic Science and Technology of China, Chengdu, 611731, ChinaSchool of Physics, University of Electronic Science and Technology of China, Chengdu, 611731, China; Corresponding author.Department of Abdominal Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, China; Corresponding author.Department of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, China; Corresponding author.Esophageal cancer is the eighth most common cancer worldwide and the sixth leading cause of cancer-related deaths. In this study, we propose a novel esophageal stent equipped with a wireless, battery-free, and movable photodynamic therapy (PDT) unit designed to treat esophageal tumors with flexibility, precision, and real-time control. This system integrates a PDT unit and an electrochemical pneumatic soft actuator into a conventional esophageal stent. Each module incorporates a piezoelectric transducer capable of receiving external ultrasound to power the respective module. These transducers selectively respond to different external ultrasound frequencies, enabling independent operation without mutual interference. The therapy module provides a light source for PDT, inducing the production of cytotoxic reactive oxygen species (ROS) in tumor cells and promoting apoptosis. The pneumatic actuator based on electrochemical principles plays a critical role in controlling the position of the PDT light source, enabling the movement of the therapy module up to 200 mm within 15 min. This allows real-time control to maintain the light source near the tumor, ensuring precise and targeted treatment. The system can wirelessly and in real-time control the PDT light source's position via external ultrasound, offering a novel approach for treating esophageal cancer patients according to the need of tumor's progression.http://www.sciencedirect.com/science/article/pii/S2590006424004551Cancer treatmentElectrochemical pneumatic soft actuatorBattery-freeWireless controlPhotodynamic therapy |
| spellingShingle | Qian Han Pingjin Zou Xianhao Wei Junyang Chen Xiaojiao Li Li Quan Ranlin Wang Lili Xing Xinyu Xue Yi Zhou Meihua Chen An esophageal stent integrated with wireless battery-free movable photodynamic-therapy unit for targeted tumor treatment Materials Today Bio Cancer treatment Electrochemical pneumatic soft actuator Battery-free Wireless control Photodynamic therapy |
| title | An esophageal stent integrated with wireless battery-free movable photodynamic-therapy unit for targeted tumor treatment |
| title_full | An esophageal stent integrated with wireless battery-free movable photodynamic-therapy unit for targeted tumor treatment |
| title_fullStr | An esophageal stent integrated with wireless battery-free movable photodynamic-therapy unit for targeted tumor treatment |
| title_full_unstemmed | An esophageal stent integrated with wireless battery-free movable photodynamic-therapy unit for targeted tumor treatment |
| title_short | An esophageal stent integrated with wireless battery-free movable photodynamic-therapy unit for targeted tumor treatment |
| title_sort | esophageal stent integrated with wireless battery free movable photodynamic therapy unit for targeted tumor treatment |
| topic | Cancer treatment Electrochemical pneumatic soft actuator Battery-free Wireless control Photodynamic therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424004551 |
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