Infliximab in treatment of refractory multisystem inflammatory syndrome in children with severe cardiac dysfunction
Multisystem inflammatory syndrome in children (MIS-C) has emerged as one of the several challenges thrown by the ongoing severe acute respiratory syndrome-coronavirus 2 pandemic. Although diagnostic criteria of MIS-C have now been established to raise the clinical suspicion for the condition, the Ka...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-01-01
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| Series: | Indian Journal of Rheumatology |
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| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2022;volume=17;issue=2;spage=166;epage=169;aulast= |
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| author | Guruprasad Hassan Shankar Jitendra S Oswal Bhakti U Sarangi Ajay Walimbe Prithvichandra Markal Karthik V Badarayan |
| author_facet | Guruprasad Hassan Shankar Jitendra S Oswal Bhakti U Sarangi Ajay Walimbe Prithvichandra Markal Karthik V Badarayan |
| author_sort | Guruprasad Hassan Shankar |
| collection | DOAJ |
| description | Multisystem inflammatory syndrome in children (MIS-C) has emerged as one of the several challenges thrown by the ongoing severe acute respiratory syndrome-coronavirus 2 pandemic. Although diagnostic criteria of MIS-C have now been established to raise the clinical suspicion for the condition, the Kawasaki disease (KD)-like phenotype of MIS-C presents with additional therapeutic dilemmas. The treatment guidance till date remains empirical with consideration of intravenous immunoglobulin (IVIG) and glucocorticoids. However, treatment of cases refractory to the current conventional therapy with respect to biologics remains uncertain. We describe here, an 8-year-old boy with MIS-C (KD-like phenotype) with severe cardiac dysfunction refractory to IVIG and pulse methylprednisolone who responded to tumor necrosis factor-α inhibition using infliximab. |
| format | Article |
| id | doaj-art-fa5b38077dc7408cb528c01b7f3adfb3 |
| institution | Kabale University |
| issn | 0973-3698 0973-3701 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Rheumatology |
| spelling | doaj-art-fa5b38077dc7408cb528c01b7f3adfb32025-01-03T01:45:47ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012022-01-0117216616910.4103/injr.injr_21_21Infliximab in treatment of refractory multisystem inflammatory syndrome in children with severe cardiac dysfunctionGuruprasad Hassan ShankarJitendra S OswalBhakti U SarangiAjay WalimbePrithvichandra MarkalKarthik V BadarayanMultisystem inflammatory syndrome in children (MIS-C) has emerged as one of the several challenges thrown by the ongoing severe acute respiratory syndrome-coronavirus 2 pandemic. Although diagnostic criteria of MIS-C have now been established to raise the clinical suspicion for the condition, the Kawasaki disease (KD)-like phenotype of MIS-C presents with additional therapeutic dilemmas. The treatment guidance till date remains empirical with consideration of intravenous immunoglobulin (IVIG) and glucocorticoids. However, treatment of cases refractory to the current conventional therapy with respect to biologics remains uncertain. We describe here, an 8-year-old boy with MIS-C (KD-like phenotype) with severe cardiac dysfunction refractory to IVIG and pulse methylprednisolone who responded to tumor necrosis factor-α inhibition using infliximab.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2022;volume=17;issue=2;spage=166;epage=169;aulast=intravenous immunoglobulinkawasaki diseasemethylprednisolonesevere acute respiratory syndrome-coronavirus 2 |
| spellingShingle | Guruprasad Hassan Shankar Jitendra S Oswal Bhakti U Sarangi Ajay Walimbe Prithvichandra Markal Karthik V Badarayan Infliximab in treatment of refractory multisystem inflammatory syndrome in children with severe cardiac dysfunction Indian Journal of Rheumatology intravenous immunoglobulin kawasaki disease methylprednisolone severe acute respiratory syndrome-coronavirus 2 |
| title | Infliximab in treatment of refractory multisystem inflammatory syndrome in children with severe cardiac dysfunction |
| title_full | Infliximab in treatment of refractory multisystem inflammatory syndrome in children with severe cardiac dysfunction |
| title_fullStr | Infliximab in treatment of refractory multisystem inflammatory syndrome in children with severe cardiac dysfunction |
| title_full_unstemmed | Infliximab in treatment of refractory multisystem inflammatory syndrome in children with severe cardiac dysfunction |
| title_short | Infliximab in treatment of refractory multisystem inflammatory syndrome in children with severe cardiac dysfunction |
| title_sort | infliximab in treatment of refractory multisystem inflammatory syndrome in children with severe cardiac dysfunction |
| topic | intravenous immunoglobulin kawasaki disease methylprednisolone severe acute respiratory syndrome-coronavirus 2 |
| url | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2022;volume=17;issue=2;spage=166;epage=169;aulast= |
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