Mollicutes/HIV Coinfection and the Development of AIDS: Still Far from a Definitive Response

Background. Mycoplasmas are known to cause various infections in humans, mainly in the respiratory and urogenital tracts. The different species are usually host-specific and cause diseases in well-defined sites. New species have been isolated, including those from HIV-infected persons. Summary. Its...

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Main Authors: Caio Mauricio Mendes de Cordova, Caroline Galgowski, Leonardo Lange
Format: Article
Language:English
Published: Wiley 2016-01-01
Series:Canadian Journal of Infectious Diseases and Medical Microbiology
Online Access:http://dx.doi.org/10.1155/2016/8192323
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author Caio Mauricio Mendes de Cordova
Caroline Galgowski
Leonardo Lange
author_facet Caio Mauricio Mendes de Cordova
Caroline Galgowski
Leonardo Lange
author_sort Caio Mauricio Mendes de Cordova
collection DOAJ
description Background. Mycoplasmas are known to cause various infections in humans, mainly in the respiratory and urogenital tracts. The different species are usually host-specific and cause diseases in well-defined sites. New species have been isolated, including those from HIV-infected persons. Summary. Its in vitro properties, combined with clinical findings, have led to the hypothesis that these microorganisms may act as cofactors of HIV in AIDS development. Even today this point of view is quite polemic among infectious disease specialists and many aspects remain to be clarified, in contrast to what happens, for instance, with HIV/Mycobacterium tuberculosis coinfection. Dozens of papers have been published covering aspects of Mollicutes/HIV coinfection, but they add little to no information about the putative contribution of Mollicutes to the evolution of AIDS. Very few researchers have devoted their efforts to trying to answer this question, which remains open. In this review, we discuss the evidences that may support this statement in the light of current knowledge in the field of mycoplasmology.
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spelling doaj-art-fa46a8f5c10f4260b8f5c6bff9bae3a72025-02-03T05:48:00ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95321918-14932016-01-01201610.1155/2016/81923238192323Mollicutes/HIV Coinfection and the Development of AIDS: Still Far from a Definitive ResponseCaio Mauricio Mendes de Cordova0Caroline Galgowski1Leonardo Lange2Department of Pharmaceutical Sciences, University of Blumenau, 89010-350 Blumenau, SC, BrazilBiomedical Sciences School, University of Blumenau, 89010-350 Blumenau, SC, BrazilBiomedical Sciences School, University of Blumenau, 89010-350 Blumenau, SC, BrazilBackground. Mycoplasmas are known to cause various infections in humans, mainly in the respiratory and urogenital tracts. The different species are usually host-specific and cause diseases in well-defined sites. New species have been isolated, including those from HIV-infected persons. Summary. Its in vitro properties, combined with clinical findings, have led to the hypothesis that these microorganisms may act as cofactors of HIV in AIDS development. Even today this point of view is quite polemic among infectious disease specialists and many aspects remain to be clarified, in contrast to what happens, for instance, with HIV/Mycobacterium tuberculosis coinfection. Dozens of papers have been published covering aspects of Mollicutes/HIV coinfection, but they add little to no information about the putative contribution of Mollicutes to the evolution of AIDS. Very few researchers have devoted their efforts to trying to answer this question, which remains open. In this review, we discuss the evidences that may support this statement in the light of current knowledge in the field of mycoplasmology.http://dx.doi.org/10.1155/2016/8192323
spellingShingle Caio Mauricio Mendes de Cordova
Caroline Galgowski
Leonardo Lange
Mollicutes/HIV Coinfection and the Development of AIDS: Still Far from a Definitive Response
Canadian Journal of Infectious Diseases and Medical Microbiology
title Mollicutes/HIV Coinfection and the Development of AIDS: Still Far from a Definitive Response
title_full Mollicutes/HIV Coinfection and the Development of AIDS: Still Far from a Definitive Response
title_fullStr Mollicutes/HIV Coinfection and the Development of AIDS: Still Far from a Definitive Response
title_full_unstemmed Mollicutes/HIV Coinfection and the Development of AIDS: Still Far from a Definitive Response
title_short Mollicutes/HIV Coinfection and the Development of AIDS: Still Far from a Definitive Response
title_sort mollicutes hiv coinfection and the development of aids still far from a definitive response
url http://dx.doi.org/10.1155/2016/8192323
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