Myoferlin alleviates pressure overload-induced cardiac hypertrophy and dysfunction by inhibiting NLRP3-mediated pyroptosis

Myoferlin alleviates pressure overload-induced cardiac hypertrophy and dysfunction by inhibiting NLRP3-mediated pyroptosis

Myoferlin (MYOF) is a muscle-derived secretory protein. Recent studies have found that MYOF protects against cell damage. However, the role of MYOF in cardiac hypertrophy remains unclear. Increasing evidence suggests that NLRP3 (NOD-like receptor protein 3) and the pyroptosis cascade play critical r...

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Bibliographic Details
Main Authors: Yang Zhou, Yanxu Liu, Hao Luo, Cong Wen, Yangyang Cui, Linqing Du, Ofe Eugene Kwaku, Lan Li, Lijuan Xiong, Jiankang Zheng, Xuefeng Ding, Xiufeng Shen, Peng Zhou, Houxiang Hu, Rongchuan Yue
Format: Article
Language:English
Published: PeerJ Inc. 2024-11-01
Series:PeerJ
Subjects:
Cardiac hypertrophy
Myoferlin
NOD-like receptor protein 3(NLRP3)
Caspase 1 (CASP1)
Online Access:https://peerj.com/articles/18499.pdf
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