CAR-T Therapy Beyond B-Cell Hematological Malignancies
Despite the advances of CAR-T cells in certain hematological malignancies, mostly from B-cell derivations such as non-Hodgkin lymphomas, acute lymphoblastic leukemia and multiple myeloma, a significant portion of other hematological and non-hematological pathologies can benefit from this innovative...
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MDPI AG
2025-01-01
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| Online Access: | https://www.mdpi.com/2073-4409/14/1/41 |
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| author | Martina Canichella Paolo de Fabritiis |
| author_facet | Martina Canichella Paolo de Fabritiis |
| author_sort | Martina Canichella |
| collection | DOAJ |
| description | Despite the advances of CAR-T cells in certain hematological malignancies, mostly from B-cell derivations such as non-Hodgkin lymphomas, acute lymphoblastic leukemia and multiple myeloma, a significant portion of other hematological and non-hematological pathologies can benefit from this innovative treatment, as the results of clinical studies are demonstrating. The clinical application of CAR-T in the setting of acute T-lymphoid leukemia, acute myeloid leukemia, solid tumors, autoimmune diseases and infections has encountered limitations that are different from those of hematological B-cell diseases. To overcome these restrictions, strategies based on different molecular engineering platforms have been devised and will be illustrated below. The aim of this manuscript is to provide an overview of the CAR-T application in pathologies other than those currently treated, highlighting both the limits and results obtained with these settings. |
| format | Article |
| id | doaj-art-f9f3676dd3f44222a3e6aae231b45dd4 |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-f9f3676dd3f44222a3e6aae231b45dd42025-01-10T13:16:20ZengMDPI AGCells2073-44092025-01-011414110.3390/cells14010041CAR-T Therapy Beyond B-Cell Hematological MalignanciesMartina Canichella0Paolo de Fabritiis1Hematology, St. Eugenio Hospital, ASL Roma2, 00144 Rome, ItalyHematology, St. Eugenio Hospital, ASL Roma2, 00144 Rome, ItalyDespite the advances of CAR-T cells in certain hematological malignancies, mostly from B-cell derivations such as non-Hodgkin lymphomas, acute lymphoblastic leukemia and multiple myeloma, a significant portion of other hematological and non-hematological pathologies can benefit from this innovative treatment, as the results of clinical studies are demonstrating. The clinical application of CAR-T in the setting of acute T-lymphoid leukemia, acute myeloid leukemia, solid tumors, autoimmune diseases and infections has encountered limitations that are different from those of hematological B-cell diseases. To overcome these restrictions, strategies based on different molecular engineering platforms have been devised and will be illustrated below. The aim of this manuscript is to provide an overview of the CAR-T application in pathologies other than those currently treated, highlighting both the limits and results obtained with these settings.https://www.mdpi.com/2073-4409/14/1/41CAR-T in hematologyCAR-T in solid neoplasiainfectious and autoimmune diseasetumor microenvironmenttumor immunosuppression |
| spellingShingle | Martina Canichella Paolo de Fabritiis CAR-T Therapy Beyond B-Cell Hematological Malignancies Cells CAR-T in hematology CAR-T in solid neoplasia infectious and autoimmune disease tumor microenvironment tumor immunosuppression |
| title | CAR-T Therapy Beyond B-Cell Hematological Malignancies |
| title_full | CAR-T Therapy Beyond B-Cell Hematological Malignancies |
| title_fullStr | CAR-T Therapy Beyond B-Cell Hematological Malignancies |
| title_full_unstemmed | CAR-T Therapy Beyond B-Cell Hematological Malignancies |
| title_short | CAR-T Therapy Beyond B-Cell Hematological Malignancies |
| title_sort | car t therapy beyond b cell hematological malignancies |
| topic | CAR-T in hematology CAR-T in solid neoplasia infectious and autoimmune disease tumor microenvironment tumor immunosuppression |
| url | https://www.mdpi.com/2073-4409/14/1/41 |
| work_keys_str_mv | AT martinacanichella carttherapybeyondbcellhematologicalmalignancies AT paolodefabritiis carttherapybeyondbcellhematologicalmalignancies |