SARS CoV-2 in tumor tissue in glioblastoma patients – preliminary study
SARS-CoV-2 infection often causes neurological disorders. Experimental studies on an animal model have shown that SARS-CoV-2 is able to cross the blood-brain barrier. Researchers have also discovered that SARS-CoV-2 can infect glial cells. Gliomas are the most common type of brain tumor. Oncological...
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| Format: | Article |
| Language: | English |
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Sciendo
2024-12-01
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| Series: | Current Issues in Pharmacy and Medical Sciences |
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| Online Access: | https://doi.org/10.2478/cipms-2024-0035 |
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| author | Brzozowski Michal Kolesnik Marcin Michalski Aleksander Drop Katarzyna Polz-Dacewicz Malgorzata |
| author_facet | Brzozowski Michal Kolesnik Marcin Michalski Aleksander Drop Katarzyna Polz-Dacewicz Malgorzata |
| author_sort | Brzozowski Michal |
| collection | DOAJ |
| description | SARS-CoV-2 infection often causes neurological disorders. Experimental studies on an animal model have shown that SARS-CoV-2 is able to cross the blood-brain barrier. Researchers have also discovered that SARS-CoV-2 can infect glial cells. Gliomas are the most common type of brain tumor. Oncological patients are at high risk of infections, including SARS-CoV-2. Moreover, their weakened immunity causes the level of antibodies after infection or vaccination to be lower than in the healthy population. Therefore, the aim of our study was to evaluate the occurrence of SARS-CoV-2 RNA in tumor tissue collected during surgery. We also tested the level of anti-SARS-CoV-2 antibodies in these patients. The obtained results indicate the tropism of the virus to tumor tissue – glioblastoma. The level of anti-SARS antibodies was higher in patients with SARS-CoV-2 RNA detected in tumour tissue. |
| format | Article |
| id | doaj-art-f9ea81494ff4408a88f592c841cbc7dd |
| institution | Kabale University |
| issn | 2300-6676 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Current Issues in Pharmacy and Medical Sciences |
| spelling | doaj-art-f9ea81494ff4408a88f592c841cbc7dd2024-12-02T12:05:33ZengSciendoCurrent Issues in Pharmacy and Medical Sciences2300-66762024-12-0137421622010.2478/cipms-2024-0035SARS CoV-2 in tumor tissue in glioblastoma patients – preliminary studyBrzozowski Michal0Kolesnik Marcin1Michalski Aleksander2Drop Katarzyna3Polz-Dacewicz Malgorzata4Neurosurgery Department, 1st Clinical Military Hospital with Outpatient Clinic, Lublin, PolandDepartment of Virology with Viral Diagnostics Laboratory, Medical University of Lublin, PolandNeurosurgery Department, 1st Clinical Military Hospital with Outpatient Clinic, Lublin, PolandDepartment of Language, Rhetoric and Media Law, Institute of Journalism and Management, Faculty of Social Sciences, Catholic University of Lublin John Paul II, PolandDepartment of Virology with Viral Diagnostics Laboratory, Medical University of Lublin, PolandSARS-CoV-2 infection often causes neurological disorders. Experimental studies on an animal model have shown that SARS-CoV-2 is able to cross the blood-brain barrier. Researchers have also discovered that SARS-CoV-2 can infect glial cells. Gliomas are the most common type of brain tumor. Oncological patients are at high risk of infections, including SARS-CoV-2. Moreover, their weakened immunity causes the level of antibodies after infection or vaccination to be lower than in the healthy population. Therefore, the aim of our study was to evaluate the occurrence of SARS-CoV-2 RNA in tumor tissue collected during surgery. We also tested the level of anti-SARS-CoV-2 antibodies in these patients. The obtained results indicate the tropism of the virus to tumor tissue – glioblastoma. The level of anti-SARS antibodies was higher in patients with SARS-CoV-2 RNA detected in tumour tissue.https://doi.org/10.2478/cipms-2024-0035sars-cov-2glioblastomasars-cov-2 antibodycovid-19 |
| spellingShingle | Brzozowski Michal Kolesnik Marcin Michalski Aleksander Drop Katarzyna Polz-Dacewicz Malgorzata SARS CoV-2 in tumor tissue in glioblastoma patients – preliminary study Current Issues in Pharmacy and Medical Sciences sars-cov-2 glioblastoma sars-cov-2 antibody covid-19 |
| title | SARS CoV-2 in tumor tissue in glioblastoma patients – preliminary study |
| title_full | SARS CoV-2 in tumor tissue in glioblastoma patients – preliminary study |
| title_fullStr | SARS CoV-2 in tumor tissue in glioblastoma patients – preliminary study |
| title_full_unstemmed | SARS CoV-2 in tumor tissue in glioblastoma patients – preliminary study |
| title_short | SARS CoV-2 in tumor tissue in glioblastoma patients – preliminary study |
| title_sort | sars cov 2 in tumor tissue in glioblastoma patients preliminary study |
| topic | sars-cov-2 glioblastoma sars-cov-2 antibody covid-19 |
| url | https://doi.org/10.2478/cipms-2024-0035 |
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