Innovative Hydrogel Design: Tailoring Immunomodulation for Optimal Chronic Wound Recovery
Abstract Despite significant progress in tissue engineering, the full regeneration of chronic wounds persists as a major challenge, with the immune response to tissue damage being a key determinant of the healing process's quality and duration. Post‐injury, a crucial aspect is the transition of...
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| Format: | Article |
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Wiley
2025-01-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202412360 |
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| author | Chun‐Mei Lai Wei‐Ji Chen Yuan Qin Di Xu Yue‐Kun Lai Shao‐Hua He |
| author_facet | Chun‐Mei Lai Wei‐Ji Chen Yuan Qin Di Xu Yue‐Kun Lai Shao‐Hua He |
| author_sort | Chun‐Mei Lai |
| collection | DOAJ |
| description | Abstract Despite significant progress in tissue engineering, the full regeneration of chronic wounds persists as a major challenge, with the immune response to tissue damage being a key determinant of the healing process's quality and duration. Post‐injury, a crucial aspect is the transition of macrophages from a pro‐inflammatory state to an anti‐inflammatory. Thus, this alteration in macrophage polarization presents an enticing avenue within the realm of regenerative medicine. Recent advancements have entailed the integration of a myriad of cellular and molecular signals into hydrogel‐based constructs, enabling the fine‐tuning of immune cell activities during different phases. This discussion explores modern insights into immune cell roles in skin regeneration, underscoring the key role of immune modulation in amplifying the overall efficacy of wounds. Moreover, a comprehensive review is presented on the latest sophisticated technologies employed in the design of immunomodulatory hydrogels to regulate macrophage polarization. Furthermore, the deliberate design of hydrogels to deliver targeted immune stimulation through manipulation of chemistry and cell integration is also emphasized. Moreover, an overview is provided regarding the influence of hydrogel properties on immune traits and tissue regeneration process. Conclusively, the accent is on forthcoming pathways directed toward modulating immune responses in the milieu of chronic healing. |
| format | Article |
| id | doaj-art-f9c4352c48914bb6ad26f3dbaa0e7ef3 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-f9c4352c48914bb6ad26f3dbaa0e7ef32025-01-13T15:29:43ZengWileyAdvanced Science2198-38442025-01-01122n/an/a10.1002/advs.202412360Innovative Hydrogel Design: Tailoring Immunomodulation for Optimal Chronic Wound RecoveryChun‐Mei Lai0Wei‐Ji Chen1Yuan Qin2Di Xu3Yue‐Kun Lai4Shao‐Hua He5College of Life Sciences Fujian Provincial Key laboratory of Haixia applied plant systems biology Fujian Agriculture and Forestry University Fuzhou Fujian 350002 P. R. ChinaShengli Clinical Medical College of Fujian Medical University Department of Pediatrics surgery, Fujian Provincial Hospital University Affiliated Provincial Hospital, Fuzhou University Affiliated Provincial Hospital 134 Dongjie Road Fuzhou Fujian 350001 P. R. ChinaCollege of Life Sciences Fujian Provincial Key laboratory of Haixia applied plant systems biology Fujian Agriculture and Forestry University Fuzhou Fujian 350002 P. R. ChinaShengli Clinical Medical College of Fujian Medical University Department of Pediatrics surgery, Fujian Provincial Hospital University Affiliated Provincial Hospital, Fuzhou University Affiliated Provincial Hospital 134 Dongjie Road Fuzhou Fujian 350001 P. R. ChinaNational Engineering Research Center of Chemical Fertilizer Catalyst (NERC‐CFC) College of Chemical Engineering Fuzhou University Fuzhou 350116 P. R. ChinaShengli Clinical Medical College of Fujian Medical University Department of Pediatrics surgery, Fujian Provincial Hospital University Affiliated Provincial Hospital, Fuzhou University Affiliated Provincial Hospital 134 Dongjie Road Fuzhou Fujian 350001 P. R. ChinaAbstract Despite significant progress in tissue engineering, the full regeneration of chronic wounds persists as a major challenge, with the immune response to tissue damage being a key determinant of the healing process's quality and duration. Post‐injury, a crucial aspect is the transition of macrophages from a pro‐inflammatory state to an anti‐inflammatory. Thus, this alteration in macrophage polarization presents an enticing avenue within the realm of regenerative medicine. Recent advancements have entailed the integration of a myriad of cellular and molecular signals into hydrogel‐based constructs, enabling the fine‐tuning of immune cell activities during different phases. This discussion explores modern insights into immune cell roles in skin regeneration, underscoring the key role of immune modulation in amplifying the overall efficacy of wounds. Moreover, a comprehensive review is presented on the latest sophisticated technologies employed in the design of immunomodulatory hydrogels to regulate macrophage polarization. Furthermore, the deliberate design of hydrogels to deliver targeted immune stimulation through manipulation of chemistry and cell integration is also emphasized. Moreover, an overview is provided regarding the influence of hydrogel properties on immune traits and tissue regeneration process. Conclusively, the accent is on forthcoming pathways directed toward modulating immune responses in the milieu of chronic healing.https://doi.org/10.1002/advs.202412360chronic woundsimmunomodulatory hydrogelmacrophage polarizationtissue |
| spellingShingle | Chun‐Mei Lai Wei‐Ji Chen Yuan Qin Di Xu Yue‐Kun Lai Shao‐Hua He Innovative Hydrogel Design: Tailoring Immunomodulation for Optimal Chronic Wound Recovery Advanced Science chronic wounds immunomodulatory hydrogel macrophage polarization tissue |
| title | Innovative Hydrogel Design: Tailoring Immunomodulation for Optimal Chronic Wound Recovery |
| title_full | Innovative Hydrogel Design: Tailoring Immunomodulation for Optimal Chronic Wound Recovery |
| title_fullStr | Innovative Hydrogel Design: Tailoring Immunomodulation for Optimal Chronic Wound Recovery |
| title_full_unstemmed | Innovative Hydrogel Design: Tailoring Immunomodulation for Optimal Chronic Wound Recovery |
| title_short | Innovative Hydrogel Design: Tailoring Immunomodulation for Optimal Chronic Wound Recovery |
| title_sort | innovative hydrogel design tailoring immunomodulation for optimal chronic wound recovery |
| topic | chronic wounds immunomodulatory hydrogel macrophage polarization tissue |
| url | https://doi.org/10.1002/advs.202412360 |
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