Putting comprehensive genomic profiling of ctDNA to work: 10 proposed use cases
Liquid biopsy profiling of circulating tumor DNA (ctDNA) has become established as a compelling, pragmatic diagnostic in the care of cancer patients and is now endorsed by multiple cancer care guidelines. Moreover, ctDNA profiling technologies have advanced significantly and offer increasingly compr...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | The Journal of Liquid Biopsy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950195424000055 |
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| author | Aakash Desai Lincoln W. Pasquina Candice Nulsen Rachel B. Keller-Evans Douglas A. Mata Hanna Tukachinsky Geoffrey R. Oxnard |
| author_facet | Aakash Desai Lincoln W. Pasquina Candice Nulsen Rachel B. Keller-Evans Douglas A. Mata Hanna Tukachinsky Geoffrey R. Oxnard |
| author_sort | Aakash Desai |
| collection | DOAJ |
| description | Liquid biopsy profiling of circulating tumor DNA (ctDNA) has become established as a compelling, pragmatic diagnostic in the care of cancer patients and is now endorsed by multiple cancer care guidelines. Moreover, ctDNA profiling technologies have advanced significantly and offer increasingly comprehensive and reliable insights into cancer. In this review, we focus on applications of ctDNA and propose that a critical untapped opportunity is in considering how we utilize these accessible, scalable technologies across diverse potential applications. With a specific focus on clinical applications, rather than research uses, we describe 10 use cases for ctDNA profiling across four categories: (1) established and (2) emerging applications of ctDNA profiling for therapy selection, (3) incidental detection of secondary genomic findings, and (4) quantification of plasma DNA tumor content. |
| format | Article |
| id | doaj-art-f9c2742f888c46c7ae7d9bf752e49e9a |
| institution | Kabale University |
| issn | 2950-1954 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Journal of Liquid Biopsy |
| spelling | doaj-art-f9c2742f888c46c7ae7d9bf752e49e9a2024-11-22T07:41:28ZengElsevierThe Journal of Liquid Biopsy2950-19542024-06-014100140Putting comprehensive genomic profiling of ctDNA to work: 10 proposed use casesAakash Desai0Lincoln W. Pasquina1Candice Nulsen2Rachel B. Keller-Evans3Douglas A. Mata4Hanna Tukachinsky5Geoffrey R. Oxnard6Division of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, AL, USAFoundation Medicine, Inc., Boston, MA, USA; Corresponding author.Foundation Medicine, Inc., Boston, MA, USAFoundation Medicine, Inc., Boston, MA, USAFoundation Medicine, Inc., Boston, MA, USAFoundation Medicine, Inc., Boston, MA, USABoston Medical Center, Boston, MA, USALiquid biopsy profiling of circulating tumor DNA (ctDNA) has become established as a compelling, pragmatic diagnostic in the care of cancer patients and is now endorsed by multiple cancer care guidelines. Moreover, ctDNA profiling technologies have advanced significantly and offer increasingly comprehensive and reliable insights into cancer. In this review, we focus on applications of ctDNA and propose that a critical untapped opportunity is in considering how we utilize these accessible, scalable technologies across diverse potential applications. With a specific focus on clinical applications, rather than research uses, we describe 10 use cases for ctDNA profiling across four categories: (1) established and (2) emerging applications of ctDNA profiling for therapy selection, (3) incidental detection of secondary genomic findings, and (4) quantification of plasma DNA tumor content.http://www.sciencedirect.com/science/article/pii/S2950195424000055Circulating tumor DNAComprehensive genomic profilingLiquid biopsy |
| spellingShingle | Aakash Desai Lincoln W. Pasquina Candice Nulsen Rachel B. Keller-Evans Douglas A. Mata Hanna Tukachinsky Geoffrey R. Oxnard Putting comprehensive genomic profiling of ctDNA to work: 10 proposed use cases The Journal of Liquid Biopsy Circulating tumor DNA Comprehensive genomic profiling Liquid biopsy |
| title | Putting comprehensive genomic profiling of ctDNA to work: 10 proposed use cases |
| title_full | Putting comprehensive genomic profiling of ctDNA to work: 10 proposed use cases |
| title_fullStr | Putting comprehensive genomic profiling of ctDNA to work: 10 proposed use cases |
| title_full_unstemmed | Putting comprehensive genomic profiling of ctDNA to work: 10 proposed use cases |
| title_short | Putting comprehensive genomic profiling of ctDNA to work: 10 proposed use cases |
| title_sort | putting comprehensive genomic profiling of ctdna to work 10 proposed use cases |
| topic | Circulating tumor DNA Comprehensive genomic profiling Liquid biopsy |
| url | http://www.sciencedirect.com/science/article/pii/S2950195424000055 |
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