New Benzimidazole 3′-Deoxynucleosides: Synthesis and Antiherpes Virus Properties

New Benzimidazole 3′-Deoxynucleosides: Synthesis and Antiherpes Virus Properties

A series of new 3′-deoxyribosides of substituted benzimidazoles was obtained by the chemo-enzymatic method using genetically engineered <i>E. coli </i>purine nucleoside phosphorylase (PNP). In the case of asymmetrically substituted benzimidazole derivatives, a mixture of N1- and N3-regio...

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Main Authors: Aleksandra O. Arnautova, Irina A. Aleksakhina, Ekaterina A. Zorina, Maria Ya. Berzina, Ilya V. Fateev, Barbara Z. Eletskaya, Konstantin V. Antonov, Olga S. Smirnova, Alexander S. Paramonov, Alexey L. Kayushin, Valeria L. Andronova, Georgii A. Galegov, Maria A. Kostromina, Evgeny A. Zayats, Inna L. Karpenko, Svetlana K. Kotovskaya, Valery N. Charushin, Roman S. Esipov, Anatoly I. Miroshnikov, Irina D. Konstantinova
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Biomolecules
Subjects:
nucleosides
fluorinated benzimidazoles
transglycosylation reaction
purine nucleoside phosphorylase
herpes simplex virus
3′-deoxyribonucleosides
Online Access:https://www.mdpi.com/2218-273X/15/7/922
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