Assessing the Correlation Between Retinal Arteriolar Bifurcation Parameters and Coronary Atherosclerosis
Abstract Introduction The aim of this study was to examine the relationship between the morphological parameters of retinal arteriolar bifurcations and coronary artery disease (CAD). Methods In this cross-sectional observational study, fundus photography was conducted on 444 participants to capture...
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Adis, Springer Healthcare
2024-10-01
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| Series: | Ophthalmology and Therapy |
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| Online Access: | https://doi.org/10.1007/s40123-024-01038-2 |
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| author | Guangzheng Dai Geng Wang Sile Yu Weinan Fu Shenming Hu Yue Huang Xinze Luan Xue Cao Xiaoting Wang Hairu Yan Xinying Liu Xingru He |
| author_facet | Guangzheng Dai Geng Wang Sile Yu Weinan Fu Shenming Hu Yue Huang Xinze Luan Xue Cao Xiaoting Wang Hairu Yan Xinying Liu Xingru He |
| author_sort | Guangzheng Dai |
| collection | DOAJ |
| description | Abstract Introduction The aim of this study was to examine the relationship between the morphological parameters of retinal arteriolar bifurcations and coronary artery disease (CAD). Methods In this cross-sectional observational study, fundus photography was conducted on 444 participants to capture retinal arteriolar bifurcations. A total of 731 fundus photographs yielded 9625 measurable bifurcations. Analyzed bifurcation parameters included the diameters of the parent vessel (d 0), the larger branch (d 1), and the smaller branch (d 2), as well as the angles (θ 1) and (θ 2) representing the orientation of each branch in relation to the parent vessel, respectively. Additionally, theoretical optimal angles ( $$\theta_{1}^{\prime}$$ θ 1 ′ ) and ( $$\theta_{2}^{\prime}$$ θ 2 ′ ), calculated from the measured parameters, provided a benchmark for ideal bifurcation geometry. The study assessed the variation in these parameters across different levels of coronary atherosclerosis severity. Results After adjusting for anatomical characteristics including the asymmetry ratio, area ratio, and distance to the optic disc, we observed that patients with severe coronary artery stenosis had significant deviations from the theoretical optimal bifurcation angles, with a decrease in ( $$\theta_{1}^{\prime}$$ θ 1 ′ ) and an increase in ( $$\theta_{2}^{\prime}$$ θ 2 ′ ) compared to those with moderate stenosis. Conclusion The findings suggest a clear alteration in retinal arteriolar bifurcation morphology among patients with severe CAD, which could potentially serve as an indicator of disease severity. |
| format | Article |
| id | doaj-art-f9b0221ae0e340b7bb0d69a3f86627fc |
| institution | Kabale University |
| issn | 2193-8245 2193-6528 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Ophthalmology and Therapy |
| spelling | doaj-art-f9b0221ae0e340b7bb0d69a3f86627fc2024-11-17T12:13:39ZengAdis, Springer HealthcareOphthalmology and Therapy2193-82452193-65282024-10-0113123079309310.1007/s40123-024-01038-2Assessing the Correlation Between Retinal Arteriolar Bifurcation Parameters and Coronary AtherosclerosisGuangzheng Dai0Geng Wang1Sile Yu2Weinan Fu3Shenming Hu4Yue Huang5Xinze Luan6Xue Cao7Xiaoting Wang8Hairu Yan9Xinying Liu10Xingru He11Dragonfleye Healthcare Technology LLCTiemei General Hospital of Liaoning Health Industry GroupDepartment of Public Health, He UniversityTiemei General Hospital of Liaoning Health Industry GroupShenyang EyeRobo Technology Co., LTDTiemei General Hospital of Liaoning Health Industry GroupDragonfleye Healthcare Technology LLCTiemei General Hospital of Liaoning Health Industry GroupDragonfleye Healthcare Technology LLCDragonfleye Healthcare Technology LLCDragonfleye Healthcare Technology LLCDepartment of Public Health, He UniversityAbstract Introduction The aim of this study was to examine the relationship between the morphological parameters of retinal arteriolar bifurcations and coronary artery disease (CAD). Methods In this cross-sectional observational study, fundus photography was conducted on 444 participants to capture retinal arteriolar bifurcations. A total of 731 fundus photographs yielded 9625 measurable bifurcations. Analyzed bifurcation parameters included the diameters of the parent vessel (d 0), the larger branch (d 1), and the smaller branch (d 2), as well as the angles (θ 1) and (θ 2) representing the orientation of each branch in relation to the parent vessel, respectively. Additionally, theoretical optimal angles ( $$\theta_{1}^{\prime}$$ θ 1 ′ ) and ( $$\theta_{2}^{\prime}$$ θ 2 ′ ), calculated from the measured parameters, provided a benchmark for ideal bifurcation geometry. The study assessed the variation in these parameters across different levels of coronary atherosclerosis severity. Results After adjusting for anatomical characteristics including the asymmetry ratio, area ratio, and distance to the optic disc, we observed that patients with severe coronary artery stenosis had significant deviations from the theoretical optimal bifurcation angles, with a decrease in ( $$\theta_{1}^{\prime}$$ θ 1 ′ ) and an increase in ( $$\theta_{2}^{\prime}$$ θ 2 ′ ) compared to those with moderate stenosis. Conclusion The findings suggest a clear alteration in retinal arteriolar bifurcation morphology among patients with severe CAD, which could potentially serve as an indicator of disease severity.https://doi.org/10.1007/s40123-024-01038-2Retinal arterioleBifurcationCoronary artery diseaseFundus imageDeep learning |
| spellingShingle | Guangzheng Dai Geng Wang Sile Yu Weinan Fu Shenming Hu Yue Huang Xinze Luan Xue Cao Xiaoting Wang Hairu Yan Xinying Liu Xingru He Assessing the Correlation Between Retinal Arteriolar Bifurcation Parameters and Coronary Atherosclerosis Ophthalmology and Therapy Retinal arteriole Bifurcation Coronary artery disease Fundus image Deep learning |
| title | Assessing the Correlation Between Retinal Arteriolar Bifurcation Parameters and Coronary Atherosclerosis |
| title_full | Assessing the Correlation Between Retinal Arteriolar Bifurcation Parameters and Coronary Atherosclerosis |
| title_fullStr | Assessing the Correlation Between Retinal Arteriolar Bifurcation Parameters and Coronary Atherosclerosis |
| title_full_unstemmed | Assessing the Correlation Between Retinal Arteriolar Bifurcation Parameters and Coronary Atherosclerosis |
| title_short | Assessing the Correlation Between Retinal Arteriolar Bifurcation Parameters and Coronary Atherosclerosis |
| title_sort | assessing the correlation between retinal arteriolar bifurcation parameters and coronary atherosclerosis |
| topic | Retinal arteriole Bifurcation Coronary artery disease Fundus image Deep learning |
| url | https://doi.org/10.1007/s40123-024-01038-2 |
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