The relationship between prenatal drought exposure and the diversity and composition of gut microbiome in pregnant women and neonates
Abstract Drought induced by climate change poses a serious threat to human health. The gut microbiome also plays a critical role in human health. However, no studies have explored the effect of drought on the human gut microbiome. Therefore, our study aimed to investigate the relationship between dr...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-024-82148-6 |
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| author | Qingbo Fang Tianlai Qiu Fenglan Chen Xuqi Tian Zijun Feng Yanan Cao Jinbing Bai Jing Huang Yanqun Liu |
| author_facet | Qingbo Fang Tianlai Qiu Fenglan Chen Xuqi Tian Zijun Feng Yanan Cao Jinbing Bai Jing Huang Yanqun Liu |
| author_sort | Qingbo Fang |
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| description | Abstract Drought induced by climate change poses a serious threat to human health. The gut microbiome also plays a critical role in human health. However, no studies have explored the effect of drought on the human gut microbiome. Therefore, our study aimed to investigate the relationship between drought and gut microbiome. Our study included 59 mothers and 38 neonates in our study. 16S rRNA V3-V4 sequencing was used to profile the gut microbiome. The Standardized Precipitation Evapotranspiration Index (SPEI) was used to represent drought characteristics. KEGG pathway level 3 was employed for functional analysis. Generalized linear models were used to explore the effect of drought on the gut microbiome. Mothers and neonates were divided into the LSPEI (Lower SPEI) group or HSPEI (Higher SPEI) group by calculating the average levels of prenatal SPEI levels. The maternal and neonatal gut microbiome exhibited similar diversities in terms of alpha and beta diversity between the LSPEI and HSPEI groups. However, notable differences were observed in their composition. We found that in the neonatal gut microbiome, Sediminibacterium and Thermovirga were positively associated with SPEI after controlling for PM2.5 in linear regression models. Additionally, SPEI was significantly associated with phenylpropanoid biosynthesis and cyanoamino acid metabolism in neonates. This study identified that prenatal SPEI levels were correlated with specific maternal and neonatal gut microbial taxa, as well as neonatal gut microbial functional pathways. Future studies should further investigate the mechanisms by which drought exposure influences maternal and neonatal gut microbial diversities, composition, and functional pathways. |
| format | Article |
| id | doaj-art-f9ac94480427419f8a57cf11d2b20c88 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-f9ac94480427419f8a57cf11d2b20c882025-01-05T12:16:59ZengNature PortfolioScientific Reports2045-23222025-01-0115111310.1038/s41598-024-82148-6The relationship between prenatal drought exposure and the diversity and composition of gut microbiome in pregnant women and neonatesQingbo Fang0Tianlai Qiu1Fenglan Chen2Xuqi Tian3Zijun Feng4Yanan Cao5Jinbing Bai6Jing Huang7Yanqun Liu8Center for Women’s and Children’s Health Research, Wuhan University School of Nursing, Wuhan UniversityCenter for Women’s and Children’s Health Research, Wuhan University School of Nursing, Wuhan UniversityCenter for Women’s and Children’s Health Research, Wuhan University School of Nursing, Wuhan UniversityCenter for Women’s and Children’s Health Research, Wuhan University School of Nursing, Wuhan UniversityCenter for Women’s and Children’s Health Research, Wuhan University School of Nursing, Wuhan UniversityCenter for Women’s and Children’s Health Research, Wuhan University School of Nursing, Wuhan UniversityEmory University Nell Hodgson Woodruff School of NursingDepartment of Occupational and Environmental Health Sciences, Peking University School of Public HealthCenter for Women’s and Children’s Health Research, Wuhan University School of Nursing, Wuhan UniversityAbstract Drought induced by climate change poses a serious threat to human health. The gut microbiome also plays a critical role in human health. However, no studies have explored the effect of drought on the human gut microbiome. Therefore, our study aimed to investigate the relationship between drought and gut microbiome. Our study included 59 mothers and 38 neonates in our study. 16S rRNA V3-V4 sequencing was used to profile the gut microbiome. The Standardized Precipitation Evapotranspiration Index (SPEI) was used to represent drought characteristics. KEGG pathway level 3 was employed for functional analysis. Generalized linear models were used to explore the effect of drought on the gut microbiome. Mothers and neonates were divided into the LSPEI (Lower SPEI) group or HSPEI (Higher SPEI) group by calculating the average levels of prenatal SPEI levels. The maternal and neonatal gut microbiome exhibited similar diversities in terms of alpha and beta diversity between the LSPEI and HSPEI groups. However, notable differences were observed in their composition. We found that in the neonatal gut microbiome, Sediminibacterium and Thermovirga were positively associated with SPEI after controlling for PM2.5 in linear regression models. Additionally, SPEI was significantly associated with phenylpropanoid biosynthesis and cyanoamino acid metabolism in neonates. This study identified that prenatal SPEI levels were correlated with specific maternal and neonatal gut microbial taxa, as well as neonatal gut microbial functional pathways. Future studies should further investigate the mechanisms by which drought exposure influences maternal and neonatal gut microbial diversities, composition, and functional pathways.https://doi.org/10.1038/s41598-024-82148-6PrenatalDroughtStandardized precipitation evapotranspiration indexMothersNeonatesGut microbiome |
| spellingShingle | Qingbo Fang Tianlai Qiu Fenglan Chen Xuqi Tian Zijun Feng Yanan Cao Jinbing Bai Jing Huang Yanqun Liu The relationship between prenatal drought exposure and the diversity and composition of gut microbiome in pregnant women and neonates Scientific Reports Prenatal Drought Standardized precipitation evapotranspiration index Mothers Neonates Gut microbiome |
| title | The relationship between prenatal drought exposure and the diversity and composition of gut microbiome in pregnant women and neonates |
| title_full | The relationship between prenatal drought exposure and the diversity and composition of gut microbiome in pregnant women and neonates |
| title_fullStr | The relationship between prenatal drought exposure and the diversity and composition of gut microbiome in pregnant women and neonates |
| title_full_unstemmed | The relationship between prenatal drought exposure and the diversity and composition of gut microbiome in pregnant women and neonates |
| title_short | The relationship between prenatal drought exposure and the diversity and composition of gut microbiome in pregnant women and neonates |
| title_sort | relationship between prenatal drought exposure and the diversity and composition of gut microbiome in pregnant women and neonates |
| topic | Prenatal Drought Standardized precipitation evapotranspiration index Mothers Neonates Gut microbiome |
| url | https://doi.org/10.1038/s41598-024-82148-6 |
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