Dynamics of SARS-CoV-2 lineages in children and adults in 2021 and 2022.
<h4>Purpose</h4>We aimed to describe SARS-CoV-2 lineages and diversity in children and adults in Estonia and similarity to travel-related cases and neighbouring countries.<h4>Methods</h4>SARS-CoV-2 sequences in 2021-2022 from a nationwide study were included. The proportion o...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0316213 |
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| author | Hiie Soeorg Aare Abroi Taavi Päll Liidia Dotsenko Erik Jaaniso Katrin Kaarna Andrio Lahesaare Paul Naaber Heiki Niglas Ott Eric Oopkaup Hedi Peterson Tuuli Reisberg Olga Sadikova Steven Smit Ulvi Gerst Talas Radko Avi Irja Lutsar Kristi Huik |
| author_facet | Hiie Soeorg Aare Abroi Taavi Päll Liidia Dotsenko Erik Jaaniso Katrin Kaarna Andrio Lahesaare Paul Naaber Heiki Niglas Ott Eric Oopkaup Hedi Peterson Tuuli Reisberg Olga Sadikova Steven Smit Ulvi Gerst Talas Radko Avi Irja Lutsar Kristi Huik |
| author_sort | Hiie Soeorg |
| collection | DOAJ |
| description | <h4>Purpose</h4>We aimed to describe SARS-CoV-2 lineages and diversity in children and adults in Estonia and similarity to travel-related cases and neighbouring countries.<h4>Methods</h4>SARS-CoV-2 sequences in 2021-2022 from a nationwide study were included. The proportion of predominant lineages in Estonian regions and among travel-related cases was described by multinomial logistic regression. Simpson's indices of diversity were compared using linear regression. Dynamics of Bray-Curtis dissimilarity was described by applying fuzzy clustering to non-metrical dimensional scaling results.<h4>Results</h4>A total of 2,630 sequences from children (<15 years) and 23,031 from adults (≥15 years) were included. The increase in the proportion of Alpha/Delta/Omicron BA.1/BA.2 lineages was delayed in smaller regions (by 3.5-27.5 days). The proportion of Alpha/Delta/Omicron BA.1 increased earlier among travel-related (n = 4,654) than non-travel-related cases (10.5 days). Diversity was lower in non-travel-related than travel-related cases until Delta period by 0.066. Dynamics of lineages and diversity were similar in adults and children. Similarity of lineages was delayed compared to Finland during Alpha/Omicron BA.1/BA.2 periods and different from all neighbouring countries during Delta period.<h4>Conclusion</h4>SARS-CoV-2 lineages in children and adults were similar. Differences between regions and travel-related cases and varying similarity to neighbouring countries suggest the importance of mobility in the spread. |
| format | Article |
| id | doaj-art-f9a4b1a9673948f99a4ecda01da659b7 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-f9a4b1a9673948f99a4ecda01da659b72025-01-08T05:32:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-011912e031621310.1371/journal.pone.0316213Dynamics of SARS-CoV-2 lineages in children and adults in 2021 and 2022.Hiie SoeorgAare AbroiTaavi PällLiidia DotsenkoErik JaanisoKatrin KaarnaAndrio LahesaarePaul NaaberHeiki NiglasOtt Eric OopkaupHedi PetersonTuuli ReisbergOlga SadikovaSteven SmitUlvi Gerst TalasRadko AviIrja LutsarKristi Huik<h4>Purpose</h4>We aimed to describe SARS-CoV-2 lineages and diversity in children and adults in Estonia and similarity to travel-related cases and neighbouring countries.<h4>Methods</h4>SARS-CoV-2 sequences in 2021-2022 from a nationwide study were included. The proportion of predominant lineages in Estonian regions and among travel-related cases was described by multinomial logistic regression. Simpson's indices of diversity were compared using linear regression. Dynamics of Bray-Curtis dissimilarity was described by applying fuzzy clustering to non-metrical dimensional scaling results.<h4>Results</h4>A total of 2,630 sequences from children (<15 years) and 23,031 from adults (≥15 years) were included. The increase in the proportion of Alpha/Delta/Omicron BA.1/BA.2 lineages was delayed in smaller regions (by 3.5-27.5 days). The proportion of Alpha/Delta/Omicron BA.1 increased earlier among travel-related (n = 4,654) than non-travel-related cases (10.5 days). Diversity was lower in non-travel-related than travel-related cases until Delta period by 0.066. Dynamics of lineages and diversity were similar in adults and children. Similarity of lineages was delayed compared to Finland during Alpha/Omicron BA.1/BA.2 periods and different from all neighbouring countries during Delta period.<h4>Conclusion</h4>SARS-CoV-2 lineages in children and adults were similar. Differences between regions and travel-related cases and varying similarity to neighbouring countries suggest the importance of mobility in the spread.https://doi.org/10.1371/journal.pone.0316213 |
| spellingShingle | Hiie Soeorg Aare Abroi Taavi Päll Liidia Dotsenko Erik Jaaniso Katrin Kaarna Andrio Lahesaare Paul Naaber Heiki Niglas Ott Eric Oopkaup Hedi Peterson Tuuli Reisberg Olga Sadikova Steven Smit Ulvi Gerst Talas Radko Avi Irja Lutsar Kristi Huik Dynamics of SARS-CoV-2 lineages in children and adults in 2021 and 2022. PLoS ONE |
| title | Dynamics of SARS-CoV-2 lineages in children and adults in 2021 and 2022. |
| title_full | Dynamics of SARS-CoV-2 lineages in children and adults in 2021 and 2022. |
| title_fullStr | Dynamics of SARS-CoV-2 lineages in children and adults in 2021 and 2022. |
| title_full_unstemmed | Dynamics of SARS-CoV-2 lineages in children and adults in 2021 and 2022. |
| title_short | Dynamics of SARS-CoV-2 lineages in children and adults in 2021 and 2022. |
| title_sort | dynamics of sars cov 2 lineages in children and adults in 2021 and 2022 |
| url | https://doi.org/10.1371/journal.pone.0316213 |
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