Faithful inheritance: Parental histone recycling and epigenetic memory in fission yeast
Accurate transmission of chromatin states during DNA replication is central to epigenetic inheritance. Recent advances have illuminated mechanisms by which parental histones, which carry key post-translational modifications, are recycled and redistributed to daughter strands. This review synthesizes...
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| Language: | English |
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Elsevier
2025-10-01
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| Series: | Cell Insight |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772892725000495 |
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| _version_ | 1849235192891310080 |
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| author | Yimeng Fang Takenori Toda Songtao Jia |
| author_facet | Yimeng Fang Takenori Toda Songtao Jia |
| author_sort | Yimeng Fang |
| collection | DOAJ |
| description | Accurate transmission of chromatin states during DNA replication is central to epigenetic inheritance. Recent advances have illuminated mechanisms by which parental histones, which carry key post-translational modifications, are recycled and redistributed to daughter strands. This review synthesizes emerging insights into the molecular machinery that mediates histone recycling during replication. It highlights the interplay between histone chaperones and replication factors and examines how perturbations in these pathways influence heterochromatin inheritance. The fission yeast serves as a powerful model for recent investigations, revealing new principles that are conserved across eukaryotes. |
| format | Article |
| id | doaj-art-f9a38d5c248a4f23a9174394c7fcd172 |
| institution | Kabale University |
| issn | 2772-8927 |
| language | English |
| publishDate | 2025-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Insight |
| spelling | doaj-art-f9a38d5c248a4f23a9174394c7fcd1722025-08-20T04:02:51ZengElsevierCell Insight2772-89272025-10-014510027510.1016/j.cellin.2025.100275Faithful inheritance: Parental histone recycling and epigenetic memory in fission yeastYimeng Fang0Takenori Toda1Songtao Jia2Department of Biological Sciences, Columbia University, New York, NY, 10027, USA; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA; Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USADepartment of Biological Sciences, Columbia University, New York, NY, 10027, USADepartment of Biological Sciences, Columbia University, New York, NY, 10027, USA; Corresponding author.Accurate transmission of chromatin states during DNA replication is central to epigenetic inheritance. Recent advances have illuminated mechanisms by which parental histones, which carry key post-translational modifications, are recycled and redistributed to daughter strands. This review synthesizes emerging insights into the molecular machinery that mediates histone recycling during replication. It highlights the interplay between histone chaperones and replication factors and examines how perturbations in these pathways influence heterochromatin inheritance. The fission yeast serves as a powerful model for recent investigations, revealing new principles that are conserved across eukaryotes.http://www.sciencedirect.com/science/article/pii/S2772892725000495Epigenetic inheritanceParental histoneDNA replicationMcm2Dpb3Dpb4 |
| spellingShingle | Yimeng Fang Takenori Toda Songtao Jia Faithful inheritance: Parental histone recycling and epigenetic memory in fission yeast Cell Insight Epigenetic inheritance Parental histone DNA replication Mcm2 Dpb3 Dpb4 |
| title | Faithful inheritance: Parental histone recycling and epigenetic memory in fission yeast |
| title_full | Faithful inheritance: Parental histone recycling and epigenetic memory in fission yeast |
| title_fullStr | Faithful inheritance: Parental histone recycling and epigenetic memory in fission yeast |
| title_full_unstemmed | Faithful inheritance: Parental histone recycling and epigenetic memory in fission yeast |
| title_short | Faithful inheritance: Parental histone recycling and epigenetic memory in fission yeast |
| title_sort | faithful inheritance parental histone recycling and epigenetic memory in fission yeast |
| topic | Epigenetic inheritance Parental histone DNA replication Mcm2 Dpb3 Dpb4 |
| url | http://www.sciencedirect.com/science/article/pii/S2772892725000495 |
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