Understanding the role of diabetes in the osteoarthritis disease and treatment process: a study protocol for the Swedish Osteoarthritis and Diabetes (SOAD) cohort
Introduction Osteoarthritis (OA) is the most common form of arthritis and a leading cause of disability worldwide. Metabolic comorbidities such as type II diabetes occur with a higher rate in people with OA than in the general population. Several factors including obesity, hyperglycaemia toxicity an...
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BMJ Publishing Group
2019-12-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/9/12/e032923.full |
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| author | Stefan Franzén Ann-Marie Svensson Ola Rolfson Martin Englund Stefan Lohmander Aleksandra Turkiewicz Andrea Dell'Isola Johanna Vinblad Emma Nauclér A W-Dahl Allan Abbott L Dahlberg |
| author_facet | Stefan Franzén Ann-Marie Svensson Ola Rolfson Martin Englund Stefan Lohmander Aleksandra Turkiewicz Andrea Dell'Isola Johanna Vinblad Emma Nauclér A W-Dahl Allan Abbott L Dahlberg |
| author_sort | Stefan Franzén |
| collection | DOAJ |
| description | Introduction Osteoarthritis (OA) is the most common form of arthritis and a leading cause of disability worldwide. Metabolic comorbidities such as type II diabetes occur with a higher rate in people with OA than in the general population. Several factors including obesity, hyperglycaemia toxicity and physical inactivity have been suggested as potential links between diabetes and OA, and have been shown to negatively impact patients’ health and quality of life. However, little is known on the role of diabetes in determining the outcome of non-surgical and surgical management of OA, and at the same time, how different OA interventions may affect diabetes control. Thus, the overall aim of this project is to explore (1) the impact of diabetes on the outcome of non-surgical and surgical OA treatments and (2) the impact of non-surgical and surgical OA treatments on diabetes control.Methods and analysis The study cohort is based on prospectively ascertained register data on a national level in Sweden. Data from OA patients who received a first-line non-surgical intervention and are registered in the National Quality Register for Better Management of Patients with Osteoarthritis will be merged with data from the Swedish Knee and Hip Arthroplasty Registers and the National Diabetes Register. Additional variables regarding patients’ use of prescribed drugs, comorbidities, socioeconomic status and cause of death will be obtained through other national health and population data registers. The linkage will be performed on an individual level using unique personal identity numbers.Ethics and dissemination This study received ethical approval (2019-02570) from the Swedish Ethical Review Authority. Results from this cohort will be submitted to peer-reviewed scientific journals and reported at the leading national and international meetings in the field. |
| format | Article |
| id | doaj-art-f9786ec280774a568b50c4b63b54f071 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-f9786ec280774a568b50c4b63b54f0712024-12-01T18:25:09ZengBMJ Publishing GroupBMJ Open2044-60552019-12-0191210.1136/bmjopen-2019-032923Understanding the role of diabetes in the osteoarthritis disease and treatment process: a study protocol for the Swedish Osteoarthritis and Diabetes (SOAD) cohortStefan Franzén0Ann-Marie Svensson1Ola Rolfson2Martin Englund3Stefan Lohmander4Aleksandra Turkiewicz5Andrea Dell'Isola6Johanna Vinblad7Emma Nauclér8A W-Dahl9Allan Abbott10L Dahlberg11Register Center Västra Götaland, Västra Götalandsregionen, Gothenburg, SwedenNational Diabetes Register, Centre of Registers in Region Västra Götaland, Goteborg, SwedenDepartment of Orthopaedicst, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenClinical Epidemiology Unit, Orthopaedics, Lund University, Lund, SwedenFaculty of Medicine, Department of Clinical Sciences, Orthopedics, Lunds University, Lund, Sweden2Lund University, Lund, SwedenFaculty of medicine, Department of Clinical Sciences, Orthopedics, Clinical Epidemiology Unit, Lund University, Lund, Sverige, SwedenCentre of Registers Västra Götaland, The Swedish Hip Arthroplasty Register, Goteborg, SwedenCentre of Registers Västra Götaland, The Swedish Hip Arthroplasty Register, Goteborg, SwedenDepartment of Clinical Sciences, Lund University, Lund, Sverige, SwedenDepartment of Medical and Health Sciences (IMH), division of physiotherapy, Faculty of Medicine and Health Sciences, Linkoping University, Linköping, Sweden4Department of Orthopedics, Institute of Clinical Sciences, Lund, SwedenIntroduction Osteoarthritis (OA) is the most common form of arthritis and a leading cause of disability worldwide. Metabolic comorbidities such as type II diabetes occur with a higher rate in people with OA than in the general population. Several factors including obesity, hyperglycaemia toxicity and physical inactivity have been suggested as potential links between diabetes and OA, and have been shown to negatively impact patients’ health and quality of life. However, little is known on the role of diabetes in determining the outcome of non-surgical and surgical management of OA, and at the same time, how different OA interventions may affect diabetes control. Thus, the overall aim of this project is to explore (1) the impact of diabetes on the outcome of non-surgical and surgical OA treatments and (2) the impact of non-surgical and surgical OA treatments on diabetes control.Methods and analysis The study cohort is based on prospectively ascertained register data on a national level in Sweden. Data from OA patients who received a first-line non-surgical intervention and are registered in the National Quality Register for Better Management of Patients with Osteoarthritis will be merged with data from the Swedish Knee and Hip Arthroplasty Registers and the National Diabetes Register. Additional variables regarding patients’ use of prescribed drugs, comorbidities, socioeconomic status and cause of death will be obtained through other national health and population data registers. The linkage will be performed on an individual level using unique personal identity numbers.Ethics and dissemination This study received ethical approval (2019-02570) from the Swedish Ethical Review Authority. Results from this cohort will be submitted to peer-reviewed scientific journals and reported at the leading national and international meetings in the field.https://bmjopen.bmj.com/content/9/12/e032923.full |
| spellingShingle | Stefan Franzén Ann-Marie Svensson Ola Rolfson Martin Englund Stefan Lohmander Aleksandra Turkiewicz Andrea Dell'Isola Johanna Vinblad Emma Nauclér A W-Dahl Allan Abbott L Dahlberg Understanding the role of diabetes in the osteoarthritis disease and treatment process: a study protocol for the Swedish Osteoarthritis and Diabetes (SOAD) cohort BMJ Open |
| title | Understanding the role of diabetes in the osteoarthritis disease and treatment process: a study protocol for the Swedish Osteoarthritis and Diabetes (SOAD) cohort |
| title_full | Understanding the role of diabetes in the osteoarthritis disease and treatment process: a study protocol for the Swedish Osteoarthritis and Diabetes (SOAD) cohort |
| title_fullStr | Understanding the role of diabetes in the osteoarthritis disease and treatment process: a study protocol for the Swedish Osteoarthritis and Diabetes (SOAD) cohort |
| title_full_unstemmed | Understanding the role of diabetes in the osteoarthritis disease and treatment process: a study protocol for the Swedish Osteoarthritis and Diabetes (SOAD) cohort |
| title_short | Understanding the role of diabetes in the osteoarthritis disease and treatment process: a study protocol for the Swedish Osteoarthritis and Diabetes (SOAD) cohort |
| title_sort | understanding the role of diabetes in the osteoarthritis disease and treatment process a study protocol for the swedish osteoarthritis and diabetes soad cohort |
| url | https://bmjopen.bmj.com/content/9/12/e032923.full |
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