XbaI polymorphism in the APOB gene and its association with increased cholesterol in children and adolescents: Ouro Preto study
Abstract Atherosclerotic vascular changes can begin during childhood, providing risk for cardiovascular disease (CVD) in adulthood. Identifiable risk factors such as dyslipidemia accelerate this process for some children. The apolipoprotein B (APOB) gene could help explain the inter-individual varia...
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Nature Portfolio
2024-12-01
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| Online Access: | https://doi.org/10.1038/s41598-024-83099-8 |
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| author | Thomás Viana de Souza Aline Priscila Batista Luiz Antônio Alves de Menezes-Júnior Anna Carolina Motta Costa Cibelle Ferreira Louzada Luciano Garcia Lourenção Wandeir Wagner de Oliveira Matheus Costa Lima Maisa Aparecida Marques Araujo Izabela Vieira Duarte Baptista Ana Carolina de Souza Soares Raquel Laranjeira Guedes George Luiz Lins Machado-Coelho |
| author_facet | Thomás Viana de Souza Aline Priscila Batista Luiz Antônio Alves de Menezes-Júnior Anna Carolina Motta Costa Cibelle Ferreira Louzada Luciano Garcia Lourenção Wandeir Wagner de Oliveira Matheus Costa Lima Maisa Aparecida Marques Araujo Izabela Vieira Duarte Baptista Ana Carolina de Souza Soares Raquel Laranjeira Guedes George Luiz Lins Machado-Coelho |
| author_sort | Thomás Viana de Souza |
| collection | DOAJ |
| description | Abstract Atherosclerotic vascular changes can begin during childhood, providing risk for cardiovascular disease (CVD) in adulthood. Identifiable risk factors such as dyslipidemia accelerate this process for some children. The apolipoprotein B (APOB) gene could help explain the inter-individual variability in lipid levels among young individuals and identify groups that require greater attention to prevent CVD. A cross-sectional study was conducted with school-aged children and adolescents in Ouro Preto, Minas Gerais. The study evaluated cardiovascular risk factors’ variables and XbaI polymorphism in the APOB gene for associations with increased total cholesterol (TC). The prevalence of increased TC was notably high, reaching 68.9% in the study population. Carriers of the variant T allele were 1.45 times more likely to develop increased TC in a dominant model (1.09–1.94, p = 0.011). After adjustments, excess weight and a family history of dyslipidemia interacted significantly with XbaI polymorphism in increased TC, resulting in Odds Ratio of 1.74 (1.11–2.71, p = 0.015) and 2.04 (1.14–3.67, p = 0.016), respectively. The results suggest that XbaI polymorphism in the APOB gene may affect the lipid profile of Brazilian children and adolescents and could contribute to the CVD in adulthood. |
| format | Article |
| id | doaj-art-f96f863e69424f869ca1ef015825e0ff |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-f96f863e69424f869ca1ef015825e0ff2024-12-29T12:17:50ZengNature PortfolioScientific Reports2045-23222024-12-0114111010.1038/s41598-024-83099-8XbaI polymorphism in the APOB gene and its association with increased cholesterol in children and adolescents: Ouro Preto studyThomás Viana de Souza0Aline Priscila Batista1Luiz Antônio Alves de Menezes-Júnior2Anna Carolina Motta Costa3Cibelle Ferreira Louzada4Luciano Garcia Lourenção5Wandeir Wagner de Oliveira6Matheus Costa Lima7Maisa Aparecida Marques Araujo8Izabela Vieira Duarte Baptista9Ana Carolina de Souza Soares10Raquel Laranjeira Guedes11George Luiz Lins Machado-Coelho12Postgraduate Program in Health and Nutrition, School of Nutrition, Federal University of Ouro PretoLaboratory of Epidemiology, School of Medicine, Federal University of Ouro PretoPostgraduate Program in Health and Nutrition, School of Nutrition, Federal University of Ouro PretoUndergraduate, School of Medicine, Federal University of Ouro PretoLaboratory of Epidemiology, School of Medicine, Federal University of Ouro PretoSchool of Nursing, Federal University of Rio GrandeLaboratory of Cardiometabolism, School of Medicine, Federal University of Ouro PretoUndergraduate, School of Medicine, Federal University of Ouro PretoUndergraduate, School of Medicine, Federal University of Ouro PretoUndergraduate, School of Medicine, Federal University of Ouro PretoUndergraduate, School of Medicine, Federal University of Ouro PretoUndergraduate, School of Medicine, Federal University of Ouro PretoPostgraduate Program in Health and Nutrition, School of Nutrition, Federal University of Ouro PretoAbstract Atherosclerotic vascular changes can begin during childhood, providing risk for cardiovascular disease (CVD) in adulthood. Identifiable risk factors such as dyslipidemia accelerate this process for some children. The apolipoprotein B (APOB) gene could help explain the inter-individual variability in lipid levels among young individuals and identify groups that require greater attention to prevent CVD. A cross-sectional study was conducted with school-aged children and adolescents in Ouro Preto, Minas Gerais. The study evaluated cardiovascular risk factors’ variables and XbaI polymorphism in the APOB gene for associations with increased total cholesterol (TC). The prevalence of increased TC was notably high, reaching 68.9% in the study population. Carriers of the variant T allele were 1.45 times more likely to develop increased TC in a dominant model (1.09–1.94, p = 0.011). After adjustments, excess weight and a family history of dyslipidemia interacted significantly with XbaI polymorphism in increased TC, resulting in Odds Ratio of 1.74 (1.11–2.71, p = 0.015) and 2.04 (1.14–3.67, p = 0.016), respectively. The results suggest that XbaI polymorphism in the APOB gene may affect the lipid profile of Brazilian children and adolescents and could contribute to the CVD in adulthood.https://doi.org/10.1038/s41598-024-83099-8Cardiovascular Risk FactorHyperlipidemiaAdolescent HealthChild HealthApolipoproteins BSingle Nucleotide Polymorphism |
| spellingShingle | Thomás Viana de Souza Aline Priscila Batista Luiz Antônio Alves de Menezes-Júnior Anna Carolina Motta Costa Cibelle Ferreira Louzada Luciano Garcia Lourenção Wandeir Wagner de Oliveira Matheus Costa Lima Maisa Aparecida Marques Araujo Izabela Vieira Duarte Baptista Ana Carolina de Souza Soares Raquel Laranjeira Guedes George Luiz Lins Machado-Coelho XbaI polymorphism in the APOB gene and its association with increased cholesterol in children and adolescents: Ouro Preto study Scientific Reports Cardiovascular Risk Factor Hyperlipidemia Adolescent Health Child Health Apolipoproteins B Single Nucleotide Polymorphism |
| title | XbaI polymorphism in the APOB gene and its association with increased cholesterol in children and adolescents: Ouro Preto study |
| title_full | XbaI polymorphism in the APOB gene and its association with increased cholesterol in children and adolescents: Ouro Preto study |
| title_fullStr | XbaI polymorphism in the APOB gene and its association with increased cholesterol in children and adolescents: Ouro Preto study |
| title_full_unstemmed | XbaI polymorphism in the APOB gene and its association with increased cholesterol in children and adolescents: Ouro Preto study |
| title_short | XbaI polymorphism in the APOB gene and its association with increased cholesterol in children and adolescents: Ouro Preto study |
| title_sort | xbai polymorphism in the apob gene and its association with increased cholesterol in children and adolescents ouro preto study |
| topic | Cardiovascular Risk Factor Hyperlipidemia Adolescent Health Child Health Apolipoproteins B Single Nucleotide Polymorphism |
| url | https://doi.org/10.1038/s41598-024-83099-8 |
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