Estimated prevalence and incidence of hypersensitivity pneumonitis in Japan
Background: The latest guidelines on hypersensitivity pneumonitis (HP) categorise the disease as either fibrotic or non-fibrotic because of the greater clinical utility of this stratification. However, the prevalence and incidence of fibrotic and non-fibrotic HP are unknown. This study assessed the...
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Elsevier
2025-01-01
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| Series: | Allergology International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S132389302400073X |
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| author | Tsukasa Okamoto Mariko Hanafusa Taketomo Abe Takashi Shimamura Masaru Ito Yoko Wakai Torahiko Jinta Katsuyuki Higa Yasuhiro Kondoh Yasumi Okouchi Ryo Okuda Masashi Bando Takafumi Suda Hiromi Tomioka Takeo Fujiwara Masato Takase Shigemi Yoshihara Hiroshi Odajima Yasunari Miyazaki |
| author_facet | Tsukasa Okamoto Mariko Hanafusa Taketomo Abe Takashi Shimamura Masaru Ito Yoko Wakai Torahiko Jinta Katsuyuki Higa Yasuhiro Kondoh Yasumi Okouchi Ryo Okuda Masashi Bando Takafumi Suda Hiromi Tomioka Takeo Fujiwara Masato Takase Shigemi Yoshihara Hiroshi Odajima Yasunari Miyazaki |
| author_sort | Tsukasa Okamoto |
| collection | DOAJ |
| description | Background: The latest guidelines on hypersensitivity pneumonitis (HP) categorise the disease as either fibrotic or non-fibrotic because of the greater clinical utility of this stratification. However, the prevalence and incidence of fibrotic and non-fibrotic HP are unknown. This study assessed the exact prevalence and incidence of fibrotic and non-fibrotic HP in Japan in 2021. Methods: For adults, the study hospitals were selected by stratified random sampling according to numbers of beds. The sampling rate was set at about 20%. The questionnaire survey was submitted to the target hospitals. For pediatric cases, a survey was distributed to all members of the Japanese Society of Pediatric Pulmonology and Japanese Society of Pediatric Allergy and Clinical Immunology. Results: Regarding adult cases, in total, 575 facilities responded to the survey, resulting in a response rate of 36.4%. The estimated prevalence and incidence of fibrotic HP were 6.3 and 2.5 per 100,000 population, respectively, versus 3.6 and 2.0 per 100,000 population, respectively, for non-fibrotic HP. Both fibrotic and non-fibrotic HP were more prevalent in southern Japan (Kyushu) and less prevalent in northern Japan (Hokkaido). The incidence of non-fibrotic HP was significantly lower in December than in the other months (relative risk ratio = 0.36, p < 0.001). Three cases of fibrotic HP and five cases of non-fibrotic HP were identified in children. Conclusions: This study determined the prevalence and incidence of fibrotic and non-fibrotic HP in Japan for the first time. |
| format | Article |
| id | doaj-art-f96dddee235a4a3680963d97dbc3c48c |
| institution | Kabale University |
| issn | 1323-8930 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj-art-f96dddee235a4a3680963d97dbc3c48c2025-01-04T04:56:04ZengElsevierAllergology International1323-89302025-01-017416671Estimated prevalence and incidence of hypersensitivity pneumonitis in JapanTsukasa Okamoto0Mariko Hanafusa1Taketomo Abe2Takashi Shimamura3Masaru Ito4Yoko Wakai5Torahiko Jinta6Katsuyuki Higa7Yasuhiro Kondoh8Yasumi Okouchi9Ryo Okuda10Masashi Bando11Takafumi Suda12Hiromi Tomioka13Takeo Fujiwara14Masato Takase15Shigemi Yoshihara16Hiroshi Odajima17Yasunari Miyazaki18Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan; Center for Personalized Medicine for Healthy Aging, Tokyo Medical and Dental University, Tokyo, JapanDepartment of Tokyo Metropolitan Health Policy Advisement, Tokyo Medical and Dental University, Tokyo, JapanDepartment of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, JapanDepartment of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, JapanDepartment of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, JapanDepartment of Respiratory Medicine, Tsuchiura Kyodo General Hospital, Ibaraki, JapanDepartment of Respiratory Medicine, St. Luke's International Hospital, Tokyo, JapanDepartment of Pulmonary Medicine, Nippon Medical School Hospital, Tokyo, JapanDepartment of Respiratory Medicine and Allergy, Tosei General Hospital, Aichi, JapanDepartment of Respiratory Medicine, Japan Community Health Organization, Tokyo Yamate Medical Center, Tokyo, JapanDepartment of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Kanagawa, JapanDivision of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Tochigi, JapanSecond Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, JapanDepartment of Respiratory Medicine, Kobe City Medical Center West Hospital, Kobe, JapanDepartment of Global Health Promotion, Tokyo Medical and Dental University, Tokyo JapanDepartment of Pediatrics, Tokyo Teishin Hospital, Tokyo, JapanDepartment of Pediatrics, Dokkyo Medical University, Tochigi, JapanDepartment of Pediatrics, NHO Fukuoka National Hospital, Fukuoka, JapanDepartment of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan; Corresponding author. Department of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.Background: The latest guidelines on hypersensitivity pneumonitis (HP) categorise the disease as either fibrotic or non-fibrotic because of the greater clinical utility of this stratification. However, the prevalence and incidence of fibrotic and non-fibrotic HP are unknown. This study assessed the exact prevalence and incidence of fibrotic and non-fibrotic HP in Japan in 2021. Methods: For adults, the study hospitals were selected by stratified random sampling according to numbers of beds. The sampling rate was set at about 20%. The questionnaire survey was submitted to the target hospitals. For pediatric cases, a survey was distributed to all members of the Japanese Society of Pediatric Pulmonology and Japanese Society of Pediatric Allergy and Clinical Immunology. Results: Regarding adult cases, in total, 575 facilities responded to the survey, resulting in a response rate of 36.4%. The estimated prevalence and incidence of fibrotic HP were 6.3 and 2.5 per 100,000 population, respectively, versus 3.6 and 2.0 per 100,000 population, respectively, for non-fibrotic HP. Both fibrotic and non-fibrotic HP were more prevalent in southern Japan (Kyushu) and less prevalent in northern Japan (Hokkaido). The incidence of non-fibrotic HP was significantly lower in December than in the other months (relative risk ratio = 0.36, p < 0.001). Three cases of fibrotic HP and five cases of non-fibrotic HP were identified in children. Conclusions: This study determined the prevalence and incidence of fibrotic and non-fibrotic HP in Japan for the first time.http://www.sciencedirect.com/science/article/pii/S132389302400073XEpidemiologic studyFibrotic hypersensitivity pneumonitisIncidenceNon-fibrotic hypersensitivity pneumonitisPrevalence |
| spellingShingle | Tsukasa Okamoto Mariko Hanafusa Taketomo Abe Takashi Shimamura Masaru Ito Yoko Wakai Torahiko Jinta Katsuyuki Higa Yasuhiro Kondoh Yasumi Okouchi Ryo Okuda Masashi Bando Takafumi Suda Hiromi Tomioka Takeo Fujiwara Masato Takase Shigemi Yoshihara Hiroshi Odajima Yasunari Miyazaki Estimated prevalence and incidence of hypersensitivity pneumonitis in Japan Allergology International Epidemiologic study Fibrotic hypersensitivity pneumonitis Incidence Non-fibrotic hypersensitivity pneumonitis Prevalence |
| title | Estimated prevalence and incidence of hypersensitivity pneumonitis in Japan |
| title_full | Estimated prevalence and incidence of hypersensitivity pneumonitis in Japan |
| title_fullStr | Estimated prevalence and incidence of hypersensitivity pneumonitis in Japan |
| title_full_unstemmed | Estimated prevalence and incidence of hypersensitivity pneumonitis in Japan |
| title_short | Estimated prevalence and incidence of hypersensitivity pneumonitis in Japan |
| title_sort | estimated prevalence and incidence of hypersensitivity pneumonitis in japan |
| topic | Epidemiologic study Fibrotic hypersensitivity pneumonitis Incidence Non-fibrotic hypersensitivity pneumonitis Prevalence |
| url | http://www.sciencedirect.com/science/article/pii/S132389302400073X |
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