Ribavirin therapy for Chikungunya arthritis
Background: Chikungunya is an acute viral infection presenting with a febrile episode and severe arthralgia, swelling of soft tissues, especially around the ankles. Many patients recover with nonspecific treatment of analgesics. Some patients continue to have subacute crippling arthritis in the legs...
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| Format: | Article |
| Language: | English |
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The Journal of Infection in Developing Countries
2008-04-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/286 |
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| author | Rajan Ravichandran Manju Manian |
| author_facet | Rajan Ravichandran Manju Manian |
| author_sort | Rajan Ravichandran |
| collection | DOAJ |
| description | Background: Chikungunya is an acute viral infection presenting with a febrile episode and severe arthralgia, swelling of soft tissues, especially around the ankles. Many patients recover with nonspecific treatment of analgesics. Some patients continue to have subacute crippling arthritis in the legs affecting their mobility. This study was undertaken to see the effect of the antiviral drug Ribavirin in the clinical outcome of these patients.
Methodology: Ten patients who continued to have crippling lower limb pains and arthritis for at least two weeks after a febrile episode were taken up for the drug study. Ten similar patients during the same period were included as controls. In the study group Ribavirin was given at 200 mg twice a day for seven days. Both groups were followed up for four weeks
Results: All patients in the drug group reported improvement in the joint pains with six of them capable of walking freely. The soft tissue swelling also reduced in eight. In three patients the pain returned after mobilization. Seven patients continued not to receive analgesics after four weeks.
Conclusions: Ribavirin may have a direct antiviral property against Chikungunya leading to faster resolution of joint and soft tissue manifestations. |
| format | Article |
| id | doaj-art-f96bfed0f8f84c4e973f2ade29ba6c5c |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2008-04-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-f96bfed0f8f84c4e973f2ade29ba6c5c2025-08-20T03:48:58ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802008-04-0120210.3855/jidc.286Ribavirin therapy for Chikungunya arthritisRajan Ravichandran0Manju Manian1Madras Institute of Nephrology, Vijaya Heath Centre, N.S.K Salai, Chennai-600026Madras Institute of Nephrology, Vijaya Heath Centre, N.S.K Salai, Chennai-600026Background: Chikungunya is an acute viral infection presenting with a febrile episode and severe arthralgia, swelling of soft tissues, especially around the ankles. Many patients recover with nonspecific treatment of analgesics. Some patients continue to have subacute crippling arthritis in the legs affecting their mobility. This study was undertaken to see the effect of the antiviral drug Ribavirin in the clinical outcome of these patients. Methodology: Ten patients who continued to have crippling lower limb pains and arthritis for at least two weeks after a febrile episode were taken up for the drug study. Ten similar patients during the same period were included as controls. In the study group Ribavirin was given at 200 mg twice a day for seven days. Both groups were followed up for four weeks Results: All patients in the drug group reported improvement in the joint pains with six of them capable of walking freely. The soft tissue swelling also reduced in eight. In three patients the pain returned after mobilization. Seven patients continued not to receive analgesics after four weeks. Conclusions: Ribavirin may have a direct antiviral property against Chikungunya leading to faster resolution of joint and soft tissue manifestations.https://jidc.org/index.php/journal/article/view/286Chikungunyalower limb arthritisRibavirinobservational study |
| spellingShingle | Rajan Ravichandran Manju Manian Ribavirin therapy for Chikungunya arthritis Journal of Infection in Developing Countries Chikungunya lower limb arthritis Ribavirin observational study |
| title | Ribavirin therapy for Chikungunya arthritis |
| title_full | Ribavirin therapy for Chikungunya arthritis |
| title_fullStr | Ribavirin therapy for Chikungunya arthritis |
| title_full_unstemmed | Ribavirin therapy for Chikungunya arthritis |
| title_short | Ribavirin therapy for Chikungunya arthritis |
| title_sort | ribavirin therapy for chikungunya arthritis |
| topic | Chikungunya lower limb arthritis Ribavirin observational study |
| url | https://jidc.org/index.php/journal/article/view/286 |
| work_keys_str_mv | AT rajanravichandran ribavirintherapyforchikungunyaarthritis AT manjumanian ribavirintherapyforchikungunyaarthritis |