Therapeutic implications and comprehensive insights into cellular senescence and aging in the tumor microenvironment of sarcoma

Therapeutic implications and comprehensive insights into cellular senescence and aging in the tumor microenvironment of sarcoma

Abstract Sarcoma (SARC), a diverse group of stromal tumors arising from mesenchymal tissues, is often associated with a poor prognosis. Emerging evidence indicates that senescent cells within the tumor microenvironment (TME) significantly contribute to cancer progression and metastasis. Although the...

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Bibliographic Details
Main Authors: Pengfei Zan, Yi Zhang, Yidong Zhu, Qingjing Chen, Zhengwei Duan, Yonghao Guan, Kaiyuan Liu, Anquan Shang, Zihua Li
Format: Article
Language:English
Published: Springer 2025-01-01
Series:Discover Oncology
Subjects:
Sarcoma
Cellular senescence
Aging
Tumor microenvironment
Online Access:https://doi.org/10.1007/s12672-025-01757-3
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