CHANGES OF 8-OXO-2'-DEOXYGUANOSINE LEVEL IN MOUSE LIVER CELLS DNA IN CASE OF ACUTE TOXIC STRESS
The changes of the 8-oxo-2'-deoxyguanosine (8-oxo-dG)/dG ratio in the DNA of laboratory mice hepatocytes under the influence of toxic stress were studied. It was shown that the injection of carbon tetrachloride causes the growth of 8-oxo-dG level. A rapid increase in the level of 8-oxo-dG in DN...
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| Language: | Russian |
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MIREA - Russian Technological University
2016-12-01
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| Series: | Тонкие химические технологии |
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| Online Access: | https://www.finechem-mirea.ru/jour/article/view/61 |
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| author | N. V. Marmiy D. S. Esipov |
| author_facet | N. V. Marmiy D. S. Esipov |
| author_sort | N. V. Marmiy |
| collection | DOAJ |
| description | The changes of the 8-oxo-2'-deoxyguanosine (8-oxo-dG)/dG ratio in the DNA of laboratory mice hepatocytes under the influence of toxic stress were studied. It was shown that the injection of carbon tetrachloride causes the growth of 8-oxo-dG level. A rapid increase in the level of 8-oxo-dG in DNA occurs during the first day of the experiment at short-term toxic stress. Subsequently, 48 hours after the initial injection, the level of 8-oxo-dG decreases to the control values. This change in the value of the biomarker can be attributed to the activation of the reparative and antioxidant systems. The subsequent injection results again in an increase of 8-oxo-dG level, and the latter only increases thereafter. This reflects the exhaustion of the reparative potential of the organism and accompanies the progress of inflammation and pathological change of the liver tissue. |
| format | Article |
| id | doaj-art-f94e8c96256b4c55bde3819cbe1c2c2c |
| institution | Kabale University |
| issn | 2410-6593 2686-7575 |
| language | Russian |
| publishDate | 2016-12-01 |
| publisher | MIREA - Russian Technological University |
| record_format | Article |
| series | Тонкие химические технологии |
| spelling | doaj-art-f94e8c96256b4c55bde3819cbe1c2c2c2025-08-20T03:42:45ZrusMIREA - Russian Technological UniversityТонкие химические технологии2410-65932686-75752016-12-01116687410.32362/2410-6593-2016-11-6-68-7461CHANGES OF 8-OXO-2'-DEOXYGUANOSINE LEVEL IN MOUSE LIVER CELLS DNA IN CASE OF ACUTE TOXIC STRESSN. V. Marmiy0D. S. Esipov1Faculty of Biology, Lomonosov Moscow State UniversityFaculty of Biology, Lomonosov Moscow State UniversityThe changes of the 8-oxo-2'-deoxyguanosine (8-oxo-dG)/dG ratio in the DNA of laboratory mice hepatocytes under the influence of toxic stress were studied. It was shown that the injection of carbon tetrachloride causes the growth of 8-oxo-dG level. A rapid increase in the level of 8-oxo-dG in DNA occurs during the first day of the experiment at short-term toxic stress. Subsequently, 48 hours after the initial injection, the level of 8-oxo-dG decreases to the control values. This change in the value of the biomarker can be attributed to the activation of the reparative and antioxidant systems. The subsequent injection results again in an increase of 8-oxo-dG level, and the latter only increases thereafter. This reflects the exhaustion of the reparative potential of the organism and accompanies the progress of inflammation and pathological change of the liver tissue.https://www.finechem-mirea.ru/jour/article/view/618-оксо-2'-дезоксигуанозинinduced cirrhosis8-oxo-2'-deoxyguanosinebiomarker of oxidative stressreversedphase hplcelectrochemical detection |
| spellingShingle | N. V. Marmiy D. S. Esipov CHANGES OF 8-OXO-2'-DEOXYGUANOSINE LEVEL IN MOUSE LIVER CELLS DNA IN CASE OF ACUTE TOXIC STRESS Тонкие химические технологии 8-оксо-2'-дезоксигуанозин induced cirrhosis 8-oxo-2'-deoxyguanosine biomarker of oxidative stress reversedphase hplc electrochemical detection |
| title | CHANGES OF 8-OXO-2'-DEOXYGUANOSINE LEVEL IN MOUSE LIVER CELLS DNA IN CASE OF ACUTE TOXIC STRESS |
| title_full | CHANGES OF 8-OXO-2'-DEOXYGUANOSINE LEVEL IN MOUSE LIVER CELLS DNA IN CASE OF ACUTE TOXIC STRESS |
| title_fullStr | CHANGES OF 8-OXO-2'-DEOXYGUANOSINE LEVEL IN MOUSE LIVER CELLS DNA IN CASE OF ACUTE TOXIC STRESS |
| title_full_unstemmed | CHANGES OF 8-OXO-2'-DEOXYGUANOSINE LEVEL IN MOUSE LIVER CELLS DNA IN CASE OF ACUTE TOXIC STRESS |
| title_short | CHANGES OF 8-OXO-2'-DEOXYGUANOSINE LEVEL IN MOUSE LIVER CELLS DNA IN CASE OF ACUTE TOXIC STRESS |
| title_sort | changes of 8 oxo 2 deoxyguanosine level in mouse liver cells dna in case of acute toxic stress |
| topic | 8-оксо-2'-дезоксигуанозин induced cirrhosis 8-oxo-2'-deoxyguanosine biomarker of oxidative stress reversedphase hplc electrochemical detection |
| url | https://www.finechem-mirea.ru/jour/article/view/61 |
| work_keys_str_mv | AT nvmarmiy changesof8oxo2deoxyguanosinelevelinmouselivercellsdnaincaseofacutetoxicstress AT dsesipov changesof8oxo2deoxyguanosinelevelinmouselivercellsdnaincaseofacutetoxicstress |