Effects of Autologous Conditioned Serum on Non-Union After Open Reduction Internal Fixation Failure: A Case Series and Literature Review
<i>Background and Objectives</i>: Non-union is a severe complication of traumatic fracture that often leads to disability and decreased quality of life, with treatment remaining complex due to a lack of standardized protocols. This study examines the effectiveness of autologous condition...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/60/11/1832 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846153044941602816 |
|---|---|
| author | Pen-Gang Cheng Man-Kuan Au Chian-Her Lee Meng-Jen Huang Kuender D. Yang Chun-Sheng Hsu Chi-Hui Wang |
| author_facet | Pen-Gang Cheng Man-Kuan Au Chian-Her Lee Meng-Jen Huang Kuender D. Yang Chun-Sheng Hsu Chi-Hui Wang |
| author_sort | Pen-Gang Cheng |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Non-union is a severe complication of traumatic fracture that often leads to disability and decreased quality of life, with treatment remaining complex due to a lack of standardized protocols. This study examines the effectiveness of autologous conditioned serum (ACS) for non-union in patients who have a failed open reduction internal fixation (ORIF). <i>Materials and Methods</i>: Eleven patients with confirmed non-union at least 9 months post-ORIF or total hip replacement were enrolled. These patients received ACS treatment on the lesion sites once to three times monthly and were followed up. Efficacy was monitored through monthly X-rays to assess callus formation and bone union. <i>Results</i>: Seven patients received ACS three times, three patients received it twice, and the one who underwent total hip replacement received it once. Ten patients achieved union at the last follow-up visit, indicating the effectiveness of ACS in non-union cases unresponsive to ORIF. ACS demonstrated promising results in facilitating bone union in these challenging cases. <i>Conclusions</i>: ACS has the potential as an alternative or adjective treatment for non-union and is worthy of being investigated further for the benefits of patients. |
| format | Article |
| id | doaj-art-f94031d312d24325a309a9fd63119477 |
| institution | Kabale University |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj-art-f94031d312d24325a309a9fd631194772024-11-26T18:12:35ZengMDPI AGMedicina1010-660X1648-91442024-11-016011183210.3390/medicina60111832Effects of Autologous Conditioned Serum on Non-Union After Open Reduction Internal Fixation Failure: A Case Series and Literature ReviewPen-Gang Cheng0Man-Kuan Au1Chian-Her Lee2Meng-Jen Huang3Kuender D. Yang4Chun-Sheng Hsu5Chi-Hui Wang6Department of Orthopedics, Fu-Ya Medical Clinic, Taichung 40764, TaiwanDepartment of Orthopedics, Cheng-Hsin General Hospital, Taipei 11220, TaiwanDepartment of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, TaiwanDepartment of Orthopedics, Taipei Tzu-Chi Hospital, Taipei 23142, TaiwanMackay Children’s Hospital, Taipei 10449, TaiwanDepartment of Physical Medicine and Rehabilitation, Taichung Veterans General Hospital, Taichung 40705, TaiwanDepartment of Orthopedics, Cheng-Ching General Hospital, Taichung 40764, Taiwan<i>Background and Objectives</i>: Non-union is a severe complication of traumatic fracture that often leads to disability and decreased quality of life, with treatment remaining complex due to a lack of standardized protocols. This study examines the effectiveness of autologous conditioned serum (ACS) for non-union in patients who have a failed open reduction internal fixation (ORIF). <i>Materials and Methods</i>: Eleven patients with confirmed non-union at least 9 months post-ORIF or total hip replacement were enrolled. These patients received ACS treatment on the lesion sites once to three times monthly and were followed up. Efficacy was monitored through monthly X-rays to assess callus formation and bone union. <i>Results</i>: Seven patients received ACS three times, three patients received it twice, and the one who underwent total hip replacement received it once. Ten patients achieved union at the last follow-up visit, indicating the effectiveness of ACS in non-union cases unresponsive to ORIF. ACS demonstrated promising results in facilitating bone union in these challenging cases. <i>Conclusions</i>: ACS has the potential as an alternative or adjective treatment for non-union and is worthy of being investigated further for the benefits of patients.https://www.mdpi.com/1648-9144/60/11/1832autologous conditioned serumfracturenon-union |
| spellingShingle | Pen-Gang Cheng Man-Kuan Au Chian-Her Lee Meng-Jen Huang Kuender D. Yang Chun-Sheng Hsu Chi-Hui Wang Effects of Autologous Conditioned Serum on Non-Union After Open Reduction Internal Fixation Failure: A Case Series and Literature Review Medicina autologous conditioned serum fracture non-union |
| title | Effects of Autologous Conditioned Serum on Non-Union After Open Reduction Internal Fixation Failure: A Case Series and Literature Review |
| title_full | Effects of Autologous Conditioned Serum on Non-Union After Open Reduction Internal Fixation Failure: A Case Series and Literature Review |
| title_fullStr | Effects of Autologous Conditioned Serum on Non-Union After Open Reduction Internal Fixation Failure: A Case Series and Literature Review |
| title_full_unstemmed | Effects of Autologous Conditioned Serum on Non-Union After Open Reduction Internal Fixation Failure: A Case Series and Literature Review |
| title_short | Effects of Autologous Conditioned Serum on Non-Union After Open Reduction Internal Fixation Failure: A Case Series and Literature Review |
| title_sort | effects of autologous conditioned serum on non union after open reduction internal fixation failure a case series and literature review |
| topic | autologous conditioned serum fracture non-union |
| url | https://www.mdpi.com/1648-9144/60/11/1832 |
| work_keys_str_mv | AT pengangcheng effectsofautologousconditionedserumonnonunionafteropenreductioninternalfixationfailureacaseseriesandliteraturereview AT mankuanau effectsofautologousconditionedserumonnonunionafteropenreductioninternalfixationfailureacaseseriesandliteraturereview AT chianherlee effectsofautologousconditionedserumonnonunionafteropenreductioninternalfixationfailureacaseseriesandliteraturereview AT mengjenhuang effectsofautologousconditionedserumonnonunionafteropenreductioninternalfixationfailureacaseseriesandliteraturereview AT kuenderdyang effectsofautologousconditionedserumonnonunionafteropenreductioninternalfixationfailureacaseseriesandliteraturereview AT chunshenghsu effectsofautologousconditionedserumonnonunionafteropenreductioninternalfixationfailureacaseseriesandliteraturereview AT chihuiwang effectsofautologousconditionedserumonnonunionafteropenreductioninternalfixationfailureacaseseriesandliteraturereview |