Causal relationship between sleep duration and attention deficit hyperactivity disorder：a two⁃sample Mendelian randomization study
<b>Objective</b> To investigate the causal relationship between sleep duration and the risk of attention deficit hyperactivity disorder（ADHD）in children using Mendelian randomization（MR）. <b>Methods</b> Genome-wide association study（GWAS）datasets for sleep duration（ukb-b-4...
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The Editorial Department of Chinese Journal of Clinical Research
2025-07-01
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| Series: | Zhongguo linchuang yanjiu |
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| Online Access: | http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20250714 |
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| _version_ | 1849224691808468992 |
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| author | DU Yuhan*，LIANG Jiahao，SONG Mingze，WANG Hai |
| author_facet | DU Yuhan*，LIANG Jiahao，SONG Mingze，WANG Hai |
| author_sort | DU Yuhan*，LIANG Jiahao，SONG Mingze，WANG Hai |
| collection | DOAJ |
| description | <b>Objective</b> To investigate the causal relationship between sleep duration and the risk of attention deficit hyperactivity disorder（ADHD）in children using Mendelian randomization（MR）. <b>Methods</b> Genome-wide association study（GWAS）datasets for sleep duration（ukb-b-4424）and ADHD（ieu-a-1183）were downloaded，and 48 single nucleotide polymorphisms（SNPs）were selected as instrumental variables（IVs）. The causal association between sleep duration and ADHD risk was assessed using inverse-variance weighted（IVW），weighted median estimator（WME）， MR-Egger regression，weighted mode，and simple mode methods，with odds ratio（OR）used to estimate the effect. Sensitivity analysis was conducted using the leave-one-out method，while horizontal pleiotropy was evaluated using the MR-Egger intercept test，and heterogeneity was assessed using a random-effects model.<b>Results</b> IVW analysis revealed a negative correlation between sleep duration and ADHD risk（ <i>OR</i>=0.597，95%<i>CI</i>：0.376-0.948，<i>P</i>=0.028）. Sensitivity analysis confirmed stable results，and the MR-Egger intercept test indicated no significant horizontal pleiotropy. The random-effects model showed no heterogeneity. <b>Conclusion</b> Increased sleep duration is associated with a reduced risk of ADHD.
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| format | Article |
| id | doaj-art-f91e2193f25c44f1b3ddd829cf017dd1 |
| institution | Kabale University |
| issn | 1674-8182 |
| language | zho |
| publishDate | 2025-07-01 |
| publisher | The Editorial Department of Chinese Journal of Clinical Research |
| record_format | Article |
| series | Zhongguo linchuang yanjiu |
| spelling | doaj-art-f91e2193f25c44f1b3ddd829cf017dd12025-08-25T07:12:14ZzhoThe Editorial Department of Chinese Journal of Clinical ResearchZhongguo linchuang yanjiu1674-81822025-07-013871043104710.13429/j.cnki.cjcr.2025.07.014Causal relationship between sleep duration and attention deficit hyperactivity disorder：a two⁃sample Mendelian randomization studyDU Yuhan*，LIANG Jiahao，SONG Mingze，WANG Hai0*Heilongjiang University of Chinese Medicine，Harbin，Heilongjiang 150040，China<b>Objective</b> To investigate the causal relationship between sleep duration and the risk of attention deficit hyperactivity disorder（ADHD）in children using Mendelian randomization（MR）. <b>Methods</b> Genome-wide association study（GWAS）datasets for sleep duration（ukb-b-4424）and ADHD（ieu-a-1183）were downloaded，and 48 single nucleotide polymorphisms（SNPs）were selected as instrumental variables（IVs）. The causal association between sleep duration and ADHD risk was assessed using inverse-variance weighted（IVW），weighted median estimator（WME）， MR-Egger regression，weighted mode，and simple mode methods，with odds ratio（OR）used to estimate the effect. Sensitivity analysis was conducted using the leave-one-out method，while horizontal pleiotropy was evaluated using the MR-Egger intercept test，and heterogeneity was assessed using a random-effects model.<b>Results</b> IVW analysis revealed a negative correlation between sleep duration and ADHD risk（ <i>OR</i>=0.597，95%<i>CI</i>：0.376-0.948，<i>P</i>=0.028）. Sensitivity analysis confirmed stable results，and the MR-Egger intercept test indicated no significant horizontal pleiotropy. The random-effects model showed no heterogeneity. <b>Conclusion</b> Increased sleep duration is associated with a reduced risk of ADHD. http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20250714sleep durationattention deficit hyperactivity disordermendelian randomizationcircadian rhythms |
| spellingShingle | DU Yuhan*，LIANG Jiahao，SONG Mingze，WANG Hai Causal relationship between sleep duration and attention deficit hyperactivity disorder：a two⁃sample Mendelian randomization study Zhongguo linchuang yanjiu sleep duration attention deficit hyperactivity disorder mendelian randomization circadian rhythms |
| title | Causal relationship between sleep duration and attention deficit hyperactivity disorder：a two⁃sample Mendelian randomization study |
| title_full | Causal relationship between sleep duration and attention deficit hyperactivity disorder：a two⁃sample Mendelian randomization study |
| title_fullStr | Causal relationship between sleep duration and attention deficit hyperactivity disorder：a two⁃sample Mendelian randomization study |
| title_full_unstemmed | Causal relationship between sleep duration and attention deficit hyperactivity disorder：a two⁃sample Mendelian randomization study |
| title_short | Causal relationship between sleep duration and attention deficit hyperactivity disorder：a two⁃sample Mendelian randomization study |
| title_sort | causal relationship between sleep duration and attention deficit hyperactivity disorder a two⁃sample mendelian randomization study |
| topic | sleep duration attention deficit hyperactivity disorder mendelian randomization circadian rhythms |
| url | http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20250714 |
| work_keys_str_mv | AT duyuhanliangjiahaosongmingzewanghai causalrelationshipbetweensleepdurationandattentiondeficithyperactivitydisorderatwosamplemendelianrandomizationstudy |