Rational strategies for designing next-generation oncolytic viruses based on transcriptome analysis of tumor cells infected with oncolytic herpes simplex virus-1

Rational strategies for designing next-generation oncolytic viruses based on transcriptome analysis of tumor cells infected with oncolytic herpes simplex virus-1

IntroductionOncolytic herpes simplex viruses (oHSVs) are a type of biotherapeutic utilized in cancer therapy due to their ability to selectively infect and destroy tumor cells without harming healthy cells. We sought to investigate the functional genomic response and altered metabolic pathways of hu...

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Bibliographic Details
Main Authors: Naeme Javid, Shahriyar Abdoli, Majid Shahbazi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Oncology
Subjects:
oncolytic
HSV-1
transcriptome
hub gene
GADD45g
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1469511/full
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