Assessing the Role of Clinicopathologic Factors in Outcome Prediction in Subjects Having Oropharyngeal Carcinoma Associated with Human Papillomavirus and Managed with Surgery
Background: Human papillomavirus (HPV) has been linked as a potential risk factor for increasing incidence of oropharyngeal carcinoma. Aim: The present study aimed to evaluate the role of clinicopathologic factors in outcome prediction in subjects having oropharyngeal carcinoma associated with HPV a...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_1436_24 |
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| _version_ | 1841543508972797952 |
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| author | Harsh Kumar Rameet Sandhu Ritesh Upadhyay Aanchal Aggarwal Rathi Rela Sahana Karthik |
| author_facet | Harsh Kumar Rameet Sandhu Ritesh Upadhyay Aanchal Aggarwal Rathi Rela Sahana Karthik |
| author_sort | Harsh Kumar |
| collection | DOAJ |
| description | Background:
Human papillomavirus (HPV) has been linked as a potential risk factor for increasing incidence of oropharyngeal carcinoma.
Aim:
The present study aimed to evaluate the role of clinicopathologic factors in outcome prediction in subjects having oropharyngeal carcinoma associated with HPV and managed with surgery.
Methods:
The present retrospective study assessed data from 54 subjects that were diagnosed with stage III or IV HPV-associated oropharyngeal carcinoma were managed with surgery with or without adjuvant therapy.
Results:
The mean follow-up duration in the study subjects was 2.7 years. The recurrence-free survival and overall survival rates [age, number of lymph nodes involved, stage of tumor, and Charleston comorbidity index] in the study subjects were 83% and 71% and 62% and 79%, respectively. The recurrence rate in the study was found to be 21%.
Conclusion:
The conclusion drawn from the present study is that some associated potential risk factors can have lesser relevance in HPV-associated oropharyngeal carcinoma. |
| format | Article |
| id | doaj-art-f90b79bb4c6d4888b2a9bece1dd1c817 |
| institution | Kabale University |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-f90b79bb4c6d4888b2a9bece1dd1c8172025-01-13T11:06:36ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062024-12-0116Suppl 4S4091S409310.4103/jpbs.jpbs_1436_24Assessing the Role of Clinicopathologic Factors in Outcome Prediction in Subjects Having Oropharyngeal Carcinoma Associated with Human Papillomavirus and Managed with SurgeryHarsh KumarRameet SandhuRitesh UpadhyayAanchal AggarwalRathi RelaSahana KarthikBackground: Human papillomavirus (HPV) has been linked as a potential risk factor for increasing incidence of oropharyngeal carcinoma. Aim: The present study aimed to evaluate the role of clinicopathologic factors in outcome prediction in subjects having oropharyngeal carcinoma associated with HPV and managed with surgery. Methods: The present retrospective study assessed data from 54 subjects that were diagnosed with stage III or IV HPV-associated oropharyngeal carcinoma were managed with surgery with or without adjuvant therapy. Results: The mean follow-up duration in the study subjects was 2.7 years. The recurrence-free survival and overall survival rates [age, number of lymph nodes involved, stage of tumor, and Charleston comorbidity index] in the study subjects were 83% and 71% and 62% and 79%, respectively. The recurrence rate in the study was found to be 21%. Conclusion: The conclusion drawn from the present study is that some associated potential risk factors can have lesser relevance in HPV-associated oropharyngeal carcinoma.https://journals.lww.com/10.4103/jpbs.jpbs_1436_24human papillomavirusoropharyngeal carcinomasurvival rates |
| spellingShingle | Harsh Kumar Rameet Sandhu Ritesh Upadhyay Aanchal Aggarwal Rathi Rela Sahana Karthik Assessing the Role of Clinicopathologic Factors in Outcome Prediction in Subjects Having Oropharyngeal Carcinoma Associated with Human Papillomavirus and Managed with Surgery Journal of Pharmacy and Bioallied Sciences human papillomavirus oropharyngeal carcinoma survival rates |
| title | Assessing the Role of Clinicopathologic Factors in Outcome Prediction in Subjects Having Oropharyngeal Carcinoma Associated with Human Papillomavirus and Managed with Surgery |
| title_full | Assessing the Role of Clinicopathologic Factors in Outcome Prediction in Subjects Having Oropharyngeal Carcinoma Associated with Human Papillomavirus and Managed with Surgery |
| title_fullStr | Assessing the Role of Clinicopathologic Factors in Outcome Prediction in Subjects Having Oropharyngeal Carcinoma Associated with Human Papillomavirus and Managed with Surgery |
| title_full_unstemmed | Assessing the Role of Clinicopathologic Factors in Outcome Prediction in Subjects Having Oropharyngeal Carcinoma Associated with Human Papillomavirus and Managed with Surgery |
| title_short | Assessing the Role of Clinicopathologic Factors in Outcome Prediction in Subjects Having Oropharyngeal Carcinoma Associated with Human Papillomavirus and Managed with Surgery |
| title_sort | assessing the role of clinicopathologic factors in outcome prediction in subjects having oropharyngeal carcinoma associated with human papillomavirus and managed with surgery |
| topic | human papillomavirus oropharyngeal carcinoma survival rates |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_1436_24 |
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