Morphokinetic features in human embryos: Analysis by our original high‐resolution time‐lapse cinematography—Summary of the past two decades
Abstract Background The pioneering work by Dr. Payne et al. in time‐lapse cinematography for observation of the morphokinetic features of human embryos inspired us to develop a new in vitro culture system with high‐resolution time‐lapse cinematography (hR‐TLC) back in 2001. Methods This in vitro cul...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
|
| Series: | Reproductive Medicine and Biology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rmb2.12578 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Abstract Background The pioneering work by Dr. Payne et al. in time‐lapse cinematography for observation of the morphokinetic features of human embryos inspired us to develop a new in vitro culture system with high‐resolution time‐lapse cinematography (hR‐TLC) back in 2001. Methods This in vitro culture system was capable of maintaining stable culture and was constructed on an inverted microscope stage. Embryos were observed and photographed noninvasively for an extended period, up to 7 days. The obtained images were displayed at a speed of 30 frames per second and individually analyzed. Results Using hR‐TLC, human fertilization and subsequent embryonic development were visualized, revealing the time course of phenomena and many unusual dynamics. Conclusion In this review, we summarize the results of our hR‐TLC analysis of early human embryonic development over the past 20 years. In the near future, it is expected that the vast amount of information obtained by hR‐TLC will be integrated into the AI system for further analysis and to provide feedback that will have the potential to improve clinical practice. In the era of SDGs and environmental awareness, we should be cautious about the direction in which AI can be utilized to avoid any further harm to the planet. |
|---|---|
| ISSN: | 1445-5781 1447-0578 |