Whole genome and reverse protein phase array landscapes of patient derived osteosarcoma xenograft models
Abstract Osteosarcoma is the most common primary bone malignancy in children and young adults, and it has few treatment options. As a result, there has been little improvement in survival outcomes in the past few decades. The need for models to test novel therapies is especially great in this diseas...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-69382-8 |
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| author | Chia-Chin Wu Licai Huang Zhongting Zhang Zhenlin Ju Xingzhi Song E. Anders Kolb Wendong Zhang Jonathan Gill Min Ha Malcolm A. Smith Peter Houghton Christopher L. Morton Raushan Kurmasheva John Maris Yael Mosse Yiling Lu Richard Gorlick P. Andrew Futreal Hannah C. Beird |
| author_facet | Chia-Chin Wu Licai Huang Zhongting Zhang Zhenlin Ju Xingzhi Song E. Anders Kolb Wendong Zhang Jonathan Gill Min Ha Malcolm A. Smith Peter Houghton Christopher L. Morton Raushan Kurmasheva John Maris Yael Mosse Yiling Lu Richard Gorlick P. Andrew Futreal Hannah C. Beird |
| author_sort | Chia-Chin Wu |
| collection | DOAJ |
| description | Abstract Osteosarcoma is the most common primary bone malignancy in children and young adults, and it has few treatment options. As a result, there has been little improvement in survival outcomes in the past few decades. The need for models to test novel therapies is especially great in this disease since it is both rare and does not respond to most therapies. To address this, an NCI-funded consortium has characterized and utilized a panel of patient-derived xenograft models of osteosarcoma for drug testing. The exomes, transcriptomes, and copy number landscapes of these models have been presented previously. This study now adds whole genome sequencing and reverse-phase protein array profiling data, which can be correlated with drug testing results. In addition, four additional osteosarcoma models are described for use in the research community. |
| format | Article |
| id | doaj-art-f8e627346ea440b7a5955c5d78e43866 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-f8e627346ea440b7a5955c5d78e438662024-12-15T12:08:27ZengNature PortfolioScientific Reports2045-23222024-08-0114111310.1038/s41598-024-69382-8Whole genome and reverse protein phase array landscapes of patient derived osteosarcoma xenograft modelsChia-Chin Wu0Licai Huang1Zhongting Zhang2Zhenlin Ju3Xingzhi Song4E. Anders Kolb5Wendong Zhang6Jonathan Gill7Min Ha8Malcolm A. Smith9Peter Houghton10Christopher L. Morton11Raushan Kurmasheva12John Maris13Yael Mosse14Yiling Lu15Richard Gorlick16P. Andrew Futreal17Hannah C. Beird18Department of Genomic Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Biostatistics, The University of Texas MD Anderson Cancer CenterPediatric Division, The University of Texas MD Anderson Cancer CenterDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer CenterDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterNemours Center for Cancer and Blood Disorders, Alfred I. DuPont Hospital for ChildrenPediatric Division, The University of Texas MD Anderson Cancer CenterPediatric Division, The University of Texas MD Anderson Cancer CenterDepartment of Biostatistics, The University of Texas MD Anderson Cancer CenterCancer Therapy Evaluation Program, National Cancer Institute, National Institutes of HealthDepartment of Molecular Medicine, University of Texas Health Science Center at San AntonioDepartment of Surgery, St. Jude Children’s Research HospitalGreehey Children’s Cancer Research InstituteChildren’s Hospital of PhiladelphiaChildren’s Hospital of PhiladelphiaDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterPediatric Division, The University of Texas MD Anderson Cancer CenterDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterAbstract Osteosarcoma is the most common primary bone malignancy in children and young adults, and it has few treatment options. As a result, there has been little improvement in survival outcomes in the past few decades. The need for models to test novel therapies is especially great in this disease since it is both rare and does not respond to most therapies. To address this, an NCI-funded consortium has characterized and utilized a panel of patient-derived xenograft models of osteosarcoma for drug testing. The exomes, transcriptomes, and copy number landscapes of these models have been presented previously. This study now adds whole genome sequencing and reverse-phase protein array profiling data, which can be correlated with drug testing results. In addition, four additional osteosarcoma models are described for use in the research community.https://doi.org/10.1038/s41598-024-69382-8 |
| spellingShingle | Chia-Chin Wu Licai Huang Zhongting Zhang Zhenlin Ju Xingzhi Song E. Anders Kolb Wendong Zhang Jonathan Gill Min Ha Malcolm A. Smith Peter Houghton Christopher L. Morton Raushan Kurmasheva John Maris Yael Mosse Yiling Lu Richard Gorlick P. Andrew Futreal Hannah C. Beird Whole genome and reverse protein phase array landscapes of patient derived osteosarcoma xenograft models Scientific Reports |
| title | Whole genome and reverse protein phase array landscapes of patient derived osteosarcoma xenograft models |
| title_full | Whole genome and reverse protein phase array landscapes of patient derived osteosarcoma xenograft models |
| title_fullStr | Whole genome and reverse protein phase array landscapes of patient derived osteosarcoma xenograft models |
| title_full_unstemmed | Whole genome and reverse protein phase array landscapes of patient derived osteosarcoma xenograft models |
| title_short | Whole genome and reverse protein phase array landscapes of patient derived osteosarcoma xenograft models |
| title_sort | whole genome and reverse protein phase array landscapes of patient derived osteosarcoma xenograft models |
| url | https://doi.org/10.1038/s41598-024-69382-8 |
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