Integrative single-cell and bulk RNA-seq analyses identify CD4+ T-cell subpopulation infiltration and biomarkers of regulatory T cells involved in mediating the progression of atherosclerotic plaque

Integrative single-cell and bulk RNA-seq analyses identify CD4+ T-cell subpopulation infiltration and biomarkers of regulatory T cells involved in mediating the progression of atherosclerotic plaque

BackgroundAtherosclerosis (AS) is a chronic inflammatory disease with a significant contributor to mortality worldwide. Regulatory T cells (Tregs) are atheroprotective. However, the potential pathways and genes associated with atherosclerotic plaque progression in Tregs remain largely unknown. There...

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Bibliographic Details
Main Authors: Yifeng Zhang, Shuxian Lu, Liang Qiu, Manman Qin, Dan Shan, Lianhua Xie, Yao Yi, Jun Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
atherosclerosis
biomarker
immune cell infiltration
regulatory T cells
single-cell RNA-seq
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1528475/full
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