Singular case report of familial hypocalciuric hypercalcemia: a rare diagnosis of hypercalcemia in the older people
Objective to report a case of familial hypocalciuric hypercalcemia (FHH) in an older patient and highlight the diagnostic challenges in geriatric populations.Case presentation We report the diagnosis of FHH in an 88-year-old polypathological patient with hypercalcemia discovered during a check-up fo...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | The Aging Male |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/13685538.2024.2436877 |
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| author | Etienne Ojardias Mélanie Leman Ludovic Lafaie Philippe Oriol Paul Calmels Thomas Celarier |
| author_facet | Etienne Ojardias Mélanie Leman Ludovic Lafaie Philippe Oriol Paul Calmels Thomas Celarier |
| author_sort | Etienne Ojardias |
| collection | DOAJ |
| description | Objective to report a case of familial hypocalciuric hypercalcemia (FHH) in an older patient and highlight the diagnostic challenges in geriatric populations.Case presentation We report the diagnosis of FHH in an 88-year-old polypathological patient with hypercalcemia discovered during a check-up for cardiac decompensation. Despite a confusing clinical presentation with gout symptoms, including repeated episodes of knee arthritis, persistent hypercalcemia conducted further investigations. Biological tests excluded primary or hyperparathyroidism and malignancy-related hyperparathyroidism, confirming the diagnosis of FHH through the detection of an inhibitory mutation in the calcium-sensing receptor gene.Conclusion This case suggests to clinicians the possibility of FHH in older patients with unexplained hypercalcemia. In geriatric patients, the diagnosis is complicated because of the poly-pathology: here hypercalcemia was associated with a confusing gout crisis, which was triggered by diuretic treatment for heart failure. |
| format | Article |
| id | doaj-art-f8cc40454e094f67b8a957a670e0ce4f |
| institution | Kabale University |
| issn | 1368-5538 1473-0790 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | The Aging Male |
| spelling | doaj-art-f8cc40454e094f67b8a957a670e0ce4f2024-12-09T08:40:58ZengTaylor & Francis GroupThe Aging Male1368-55381473-07902025-12-0128110.1080/13685538.2024.2436877Singular case report of familial hypocalciuric hypercalcemia: a rare diagnosis of hypercalcemia in the older peopleEtienne Ojardias0Mélanie Leman1Ludovic Lafaie2Philippe Oriol3Paul Calmels4Thomas Celarier5Clinical Gerontology Department, University Hospital of Saint-Etienne, Saint-Etienne, FranceClinical Gerontology Department, Hospital of Saint-Chamond, Saint-Chamond, FranceClinical Gerontology Department, University Hospital of Saint-Etienne, Saint-Etienne, FranceClinical Gerontology Department, University Hospital of Saint-Etienne, Saint-Etienne, FranceInter-university Laboratory of Human Movement Biology, Saint-Etienne “Jean Monnet” & Lyon 1 & “Savoie Mont-Blanc” universities, Saint-Etienne, FranceClinical Gerontology Department, University Hospital of Saint-Etienne, Saint-Etienne, FranceObjective to report a case of familial hypocalciuric hypercalcemia (FHH) in an older patient and highlight the diagnostic challenges in geriatric populations.Case presentation We report the diagnosis of FHH in an 88-year-old polypathological patient with hypercalcemia discovered during a check-up for cardiac decompensation. Despite a confusing clinical presentation with gout symptoms, including repeated episodes of knee arthritis, persistent hypercalcemia conducted further investigations. Biological tests excluded primary or hyperparathyroidism and malignancy-related hyperparathyroidism, confirming the diagnosis of FHH through the detection of an inhibitory mutation in the calcium-sensing receptor gene.Conclusion This case suggests to clinicians the possibility of FHH in older patients with unexplained hypercalcemia. In geriatric patients, the diagnosis is complicated because of the poly-pathology: here hypercalcemia was associated with a confusing gout crisis, which was triggered by diuretic treatment for heart failure.https://www.tandfonline.com/doi/10.1080/13685538.2024.2436877Hypercalcemiaolder peoplepolypathologyfamilial hypocalciuric hypercalcemia |
| spellingShingle | Etienne Ojardias Mélanie Leman Ludovic Lafaie Philippe Oriol Paul Calmels Thomas Celarier Singular case report of familial hypocalciuric hypercalcemia: a rare diagnosis of hypercalcemia in the older people The Aging Male Hypercalcemia older people polypathology familial hypocalciuric hypercalcemia |
| title | Singular case report of familial hypocalciuric hypercalcemia: a rare diagnosis of hypercalcemia in the older people |
| title_full | Singular case report of familial hypocalciuric hypercalcemia: a rare diagnosis of hypercalcemia in the older people |
| title_fullStr | Singular case report of familial hypocalciuric hypercalcemia: a rare diagnosis of hypercalcemia in the older people |
| title_full_unstemmed | Singular case report of familial hypocalciuric hypercalcemia: a rare diagnosis of hypercalcemia in the older people |
| title_short | Singular case report of familial hypocalciuric hypercalcemia: a rare diagnosis of hypercalcemia in the older people |
| title_sort | singular case report of familial hypocalciuric hypercalcemia a rare diagnosis of hypercalcemia in the older people |
| topic | Hypercalcemia older people polypathology familial hypocalciuric hypercalcemia |
| url | https://www.tandfonline.com/doi/10.1080/13685538.2024.2436877 |
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