Association between postoperative intravenous methylprednisolone and surgical site infection in posterior lumbar fusion surgery: a retrospective single-center study
Abstract Purpose To investigate the association between intravenous methylprednisolone administration and the risk of surgical site infection (SSI) following posterior lumbar fusion (PLF) surgery. Methods This retrospective, single-center study analyzed data from 800 adult patients who underwent ele...
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BMC
2024-12-01
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| Series: | BMC Musculoskeletal Disorders |
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| Online Access: | https://doi.org/10.1186/s12891-024-08145-y |
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| author | Yuancheng Zhang Jiahua Xie Tianzuo Niu Siping Deng Jianru Wang Hui Liu Zemin Li |
| author_facet | Yuancheng Zhang Jiahua Xie Tianzuo Niu Siping Deng Jianru Wang Hui Liu Zemin Li |
| author_sort | Yuancheng Zhang |
| collection | DOAJ |
| description | Abstract Purpose To investigate the association between intravenous methylprednisolone administration and the risk of surgical site infection (SSI) following posterior lumbar fusion (PLF) surgery. Methods This retrospective, single-center study analyzed data from 800 adult patients who underwent elective PLF surgery at our institution. Patients were classified according to postoperative intravenous methylprednisolone administration. Univariate and multivariable logistic regression, and subgroup analysis were used to assess the association between methylprednisolone administration and SSI risk, as well as its impact on postoperative pain management. Results Our analysis showed no significant association between intravenous methylprednisolone administration and the development of a SSI after PLF. Subgroup analyses suggested that methylprednisolone was potentially protective in patients with a body mass index (BMI) < 25 kg/m2. In addition, patients treated with methylprednisolone had significantly lower pain scores in the early postoperative period, and lower incidence of postoperative nausea and vomiting (PONV) compared to patients not treated with methylprednisolone. However, there was no significant difference in pain scores between the 2 groups at 4 weeks postoperatively. Conclusions This study suggests that intravenous methylprednisolone administration may not increase the risk of SSI after single-level PLF. In addition, it appears to have a beneficial effect on postoperative pain management and PONV, especially during the early recovery phase. |
| format | Article |
| id | doaj-art-f8c412bfbe8b4d9db00a34799e49ae06 |
| institution | Kabale University |
| issn | 1471-2474 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj-art-f8c412bfbe8b4d9db00a34799e49ae062024-12-22T12:07:29ZengBMCBMC Musculoskeletal Disorders1471-24742024-12-0125111110.1186/s12891-024-08145-yAssociation between postoperative intravenous methylprednisolone and surgical site infection in posterior lumbar fusion surgery: a retrospective single-center studyYuancheng Zhang0Jiahua Xie1Tianzuo Niu2Siping Deng3Jianru Wang4Hui Liu5Zemin Li6Department of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen UniversityAbstract Purpose To investigate the association between intravenous methylprednisolone administration and the risk of surgical site infection (SSI) following posterior lumbar fusion (PLF) surgery. Methods This retrospective, single-center study analyzed data from 800 adult patients who underwent elective PLF surgery at our institution. Patients were classified according to postoperative intravenous methylprednisolone administration. Univariate and multivariable logistic regression, and subgroup analysis were used to assess the association between methylprednisolone administration and SSI risk, as well as its impact on postoperative pain management. Results Our analysis showed no significant association between intravenous methylprednisolone administration and the development of a SSI after PLF. Subgroup analyses suggested that methylprednisolone was potentially protective in patients with a body mass index (BMI) < 25 kg/m2. In addition, patients treated with methylprednisolone had significantly lower pain scores in the early postoperative period, and lower incidence of postoperative nausea and vomiting (PONV) compared to patients not treated with methylprednisolone. However, there was no significant difference in pain scores between the 2 groups at 4 weeks postoperatively. Conclusions This study suggests that intravenous methylprednisolone administration may not increase the risk of SSI after single-level PLF. In addition, it appears to have a beneficial effect on postoperative pain management and PONV, especially during the early recovery phase.https://doi.org/10.1186/s12891-024-08145-ySurgical site infectionIntravenous methylprednisone administrationPosterior lumbar fusionPain management |
| spellingShingle | Yuancheng Zhang Jiahua Xie Tianzuo Niu Siping Deng Jianru Wang Hui Liu Zemin Li Association between postoperative intravenous methylprednisolone and surgical site infection in posterior lumbar fusion surgery: a retrospective single-center study BMC Musculoskeletal Disorders Surgical site infection Intravenous methylprednisone administration Posterior lumbar fusion Pain management |
| title | Association between postoperative intravenous methylprednisolone and surgical site infection in posterior lumbar fusion surgery: a retrospective single-center study |
| title_full | Association between postoperative intravenous methylprednisolone and surgical site infection in posterior lumbar fusion surgery: a retrospective single-center study |
| title_fullStr | Association between postoperative intravenous methylprednisolone and surgical site infection in posterior lumbar fusion surgery: a retrospective single-center study |
| title_full_unstemmed | Association between postoperative intravenous methylprednisolone and surgical site infection in posterior lumbar fusion surgery: a retrospective single-center study |
| title_short | Association between postoperative intravenous methylprednisolone and surgical site infection in posterior lumbar fusion surgery: a retrospective single-center study |
| title_sort | association between postoperative intravenous methylprednisolone and surgical site infection in posterior lumbar fusion surgery a retrospective single center study |
| topic | Surgical site infection Intravenous methylprednisone administration Posterior lumbar fusion Pain management |
| url | https://doi.org/10.1186/s12891-024-08145-y |
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