Frailty index, frailty phenotype and 6-year mortality trends in the FRASNET cohort
BackgroundFrailty, a geriatric syndrome associated with adverse outcomes, lacks a universal definition. No consensus exists on the most effective frailty scale for predicting mortality.MethodsThis prospective observational study followed community-dwelling volunteers for 6 years. Frailty was measure...
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Frontiers Media S.A.
2025-01-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1465066/full |
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| author | Sarah Damanti Sarah Damanti Rebecca De Lorenzo Rebecca De Lorenzo Lorena Citterio Laura Zagato Elena Brioni Cristiano Magnaghi Marco Simonini Maria Pia Ruggiero Simona Santoro Eleonora Senini Marco Messina Francesca Farina Costanza Festorazzi Giordano Vitali Paolo Manunta Paolo Manunta Angelo Andrea Manfredi Chiara Lanzani Chiara Lanzani Patrizia Rovere-Querini Patrizia Rovere-Querini |
| author_facet | Sarah Damanti Sarah Damanti Rebecca De Lorenzo Rebecca De Lorenzo Lorena Citterio Laura Zagato Elena Brioni Cristiano Magnaghi Marco Simonini Maria Pia Ruggiero Simona Santoro Eleonora Senini Marco Messina Francesca Farina Costanza Festorazzi Giordano Vitali Paolo Manunta Paolo Manunta Angelo Andrea Manfredi Chiara Lanzani Chiara Lanzani Patrizia Rovere-Querini Patrizia Rovere-Querini |
| author_sort | Sarah Damanti |
| collection | DOAJ |
| description | BackgroundFrailty, a geriatric syndrome associated with adverse outcomes, lacks a universal definition. No consensus exists on the most effective frailty scale for predicting mortality.MethodsThis prospective observational study followed community-dwelling volunteers for 6 years. Frailty was measured with the Frailty Index (FI) and the Frailty Phenotype (FP). Concordance was assessed using Cohen’s Kappa coefficients. Age-and sex-adjusted Cox regression analyses were conducted to evaluate the association with mortality.ResultsOut of 1,114 participants (median age 72 years, IQR 69–77), 186 were classified as frail by the FI, 13 by the FP and 48 by both definitions. The concordance between the two measures was fair (κ = 0.26). Thirty-nine individuals died during the follow-up period. The FI showed a stronger association with mortality (HR 75.29, 95% CI 8.12–697.68, p < 0.001) compared to the FP (HR 3.3, 95% CI 1.45–7.51, p = 0.004). Individuals classified as frail by both definitions had the highest mortality risk and the highest FI scores (median 0.36).ConclusionDefinitions of frailty identify different individuals as frail. The FI was more closely related to mortality than the FP. Individuals classified as frail according to both definitions displayed the highest complexity (corresponding also ho higher FI scores) and the greatest mortality. The FI demonstrated a more accurate ability to predict mortality due to its comprehensive nature. |
| format | Article |
| id | doaj-art-f8c3b48fbbe846b1bfc418364872a136 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-f8c3b48fbbe846b1bfc418364872a1362025-01-08T06:11:39ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.14650661465066Frailty index, frailty phenotype and 6-year mortality trends in the FRASNET cohortSarah Damanti0Sarah Damanti1Rebecca De Lorenzo2Rebecca De Lorenzo3Lorena Citterio4Laura Zagato5Elena Brioni6Cristiano Magnaghi7Marco Simonini8Maria Pia Ruggiero9Simona Santoro10Eleonora Senini11Marco Messina12Francesca Farina13Costanza Festorazzi14Giordano Vitali15Paolo Manunta16Paolo Manunta17Angelo Andrea Manfredi18Chiara Lanzani19Chiara Lanzani20Patrizia Rovere-Querini21Patrizia Rovere-Querini22Internal Medicine Unit, IRCCS San Raffaele Scientific Institute, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyInternal Medicine Unit, IRCCS San Raffaele Scientific Institute, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyNephrology and Dialysis Unit, IRCCS San Raffaele Scientific Institute, Milan, ItalyNephrology and Dialysis Unit, IRCCS San Raffaele Scientific Institute, Milan, ItalyInternal Medicine Unit, IRCCS San Raffaele Scientific Institute, Milan, ItalyScientific Technical Secretariat of the Ethics Committee. IRCCS San Raffaele Scientific Institute, Milan, ItalyNephrology and Dialysis Unit, IRCCS San Raffaele Scientific Institute, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyInternal Medicine Unit, IRCCS San Raffaele Scientific Institute, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyScientific Technical Secretariat of the Ethics Committee. IRCCS San Raffaele Scientific Institute, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyScientific Technical Secretariat of the Ethics Committee. IRCCS San Raffaele Scientific Institute, Milan, ItalyInternal Medicine Unit, IRCCS San Raffaele Scientific Institute, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyBackgroundFrailty, a geriatric syndrome associated with adverse outcomes, lacks a universal definition. No consensus exists on the most effective frailty scale for predicting mortality.MethodsThis prospective observational study followed community-dwelling volunteers for 6 years. Frailty was measured with the Frailty Index (FI) and the Frailty Phenotype (FP). Concordance was assessed using Cohen’s Kappa coefficients. Age-and sex-adjusted Cox regression analyses were conducted to evaluate the association with mortality.ResultsOut of 1,114 participants (median age 72 years, IQR 69–77), 186 were classified as frail by the FI, 13 by the FP and 48 by both definitions. The concordance between the two measures was fair (κ = 0.26). Thirty-nine individuals died during the follow-up period. The FI showed a stronger association with mortality (HR 75.29, 95% CI 8.12–697.68, p < 0.001) compared to the FP (HR 3.3, 95% CI 1.45–7.51, p = 0.004). Individuals classified as frail by both definitions had the highest mortality risk and the highest FI scores (median 0.36).ConclusionDefinitions of frailty identify different individuals as frail. The FI was more closely related to mortality than the FP. Individuals classified as frail according to both definitions displayed the highest complexity (corresponding also ho higher FI scores) and the greatest mortality. The FI demonstrated a more accurate ability to predict mortality due to its comprehensive nature.https://www.frontiersin.org/articles/10.3389/fmed.2024.1465066/fullfrailty indexfrailty phenotypemortalitycommunity dwelling older peopleolder people |
| spellingShingle | Sarah Damanti Sarah Damanti Rebecca De Lorenzo Rebecca De Lorenzo Lorena Citterio Laura Zagato Elena Brioni Cristiano Magnaghi Marco Simonini Maria Pia Ruggiero Simona Santoro Eleonora Senini Marco Messina Francesca Farina Costanza Festorazzi Giordano Vitali Paolo Manunta Paolo Manunta Angelo Andrea Manfredi Chiara Lanzani Chiara Lanzani Patrizia Rovere-Querini Patrizia Rovere-Querini Frailty index, frailty phenotype and 6-year mortality trends in the FRASNET cohort Frontiers in Medicine frailty index frailty phenotype mortality community dwelling older people older people |
| title | Frailty index, frailty phenotype and 6-year mortality trends in the FRASNET cohort |
| title_full | Frailty index, frailty phenotype and 6-year mortality trends in the FRASNET cohort |
| title_fullStr | Frailty index, frailty phenotype and 6-year mortality trends in the FRASNET cohort |
| title_full_unstemmed | Frailty index, frailty phenotype and 6-year mortality trends in the FRASNET cohort |
| title_short | Frailty index, frailty phenotype and 6-year mortality trends in the FRASNET cohort |
| title_sort | frailty index frailty phenotype and 6 year mortality trends in the frasnet cohort |
| topic | frailty index frailty phenotype mortality community dwelling older people older people |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1465066/full |
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