Therapeutic plasma exchange accelerates immune cell recovery in severe COVID-19

Therapeutic plasma exchange accelerates immune cell recovery in severe COVID-19

BackgroundImmunological disturbances (anti-type I IFN auto-antibody production, cytokine storm, lymphopenia, T-cell hyperactivation and exhaustion) are responsible for disease exacerbation during severe COVID-19 infections.MethodsIn this study, we set up a prospective, randomised clinical trial (Cli...

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Main Authors: Aurelie Guironnet-Paquet, Hind Hamzeh-Cognasse, Frederic Berard, Fabrice Cognasse, Jean Christophe Richard, Hodane Yonis, Mehdi Mezidi, Olivier Desebbe, Bertrand Delannoy, Sophie Demeret, Clemence Marois, Samir Saheb, Quoc Viet Le, Mathieu Schoeffler, Paul Simon Pugliesi, Sophie Debord, Paul Bastard, Aurélie Cobat, Jean Laurent Casanova, Rémi Pescarmona, Sébastien Viel, Jean François Nicolas, Audrey Nosbaum, Marc Vocanson, Olivier Hequet
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
COVID-19
therapeutic plasma exchange
immune response
anti-type I IFN autoantibodies
cytokine storm
adaptive immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1492672/full
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