Delivery of Prime editing in human stem cells using pseudoviral NanoScribes particles

Delivery of Prime editing in human stem cells using pseudoviral NanoScribes particles

Abstract Prime Editing can rewrite genes in living cells by allowing point mutations, deletions, or insertion of small DNA sequences with high precision. However, its safe and efficient delivery into human stem cells remains a technical challenge. In this report, we engineer Nanoscribes, virus-like...

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Bibliographic Details
Main Authors: Thibaut Halegua, Valérie Risson, Julien Carras, Martin Rouyer, Laurent Coudert, Arnaud Jacquier, Laurent Schaeffer, Théophile Ohlmann, Philippe Emmanuel Mangeot
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55604-0
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