Advances in the Understanding of the Pathogenesis of Triple‐Negative Breast Cancer
ABSTRACT Background Triple‐negative breast cancer (TNBC) is a heterogeneous disease characterized by high aggressiveness, high malignancy, and poor prognosis compared to other breast cancer subtypes. Objective This review aims to explore recent advances in understanding TNBC and to provide new insig...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-11-01
|
| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.70410 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846121431877812224 |
|---|---|
| author | Yuhan Liu Yuhan Zou Yangli Ye Yong Chen |
| author_facet | Yuhan Liu Yuhan Zou Yangli Ye Yong Chen |
| author_sort | Yuhan Liu |
| collection | DOAJ |
| description | ABSTRACT Background Triple‐negative breast cancer (TNBC) is a heterogeneous disease characterized by high aggressiveness, high malignancy, and poor prognosis compared to other breast cancer subtypes. Objective This review aims to explore recent advances in understanding TNBC and to provide new insights and potential references for clinical treatment. Methods We examined current literature on TNBC to analyze molecular subtypes, genetic mutations, signaling pathways, mechanisms of drug resistance, and emerging therapies. Results Findings highlight key aspects of TNBC's molecular subtypes, relevant mutations, and pathways, alongside emerging treatments that target drug resistance mechanisms. Conclusion These insights into TNBC pathogenesis may help guide future therapeutic strategies and improve clinical outcomes for patients with TNBC. |
| format | Article |
| id | doaj-art-f8a12f6d06bc44c69d4b36a92cb52f34 |
| institution | Kabale University |
| issn | 2045-7634 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-f8a12f6d06bc44c69d4b36a92cb52f342024-12-16T05:15:42ZengWileyCancer Medicine2045-76342024-11-011322n/an/a10.1002/cam4.70410Advances in the Understanding of the Pathogenesis of Triple‐Negative Breast CancerYuhan Liu0Yuhan Zou1Yangli Ye2Yong Chen3School of Clinical Medicine Shandong Second Medical University Weifang ChinaSchool of Clinical Medicine Shandong Second Medical University Weifang ChinaCollege of Life Sciences and Technology Shandong Second Medical University Weifang ChinaKey Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences Shandong Second Medical University Weifang ChinaABSTRACT Background Triple‐negative breast cancer (TNBC) is a heterogeneous disease characterized by high aggressiveness, high malignancy, and poor prognosis compared to other breast cancer subtypes. Objective This review aims to explore recent advances in understanding TNBC and to provide new insights and potential references for clinical treatment. Methods We examined current literature on TNBC to analyze molecular subtypes, genetic mutations, signaling pathways, mechanisms of drug resistance, and emerging therapies. Results Findings highlight key aspects of TNBC's molecular subtypes, relevant mutations, and pathways, alongside emerging treatments that target drug resistance mechanisms. Conclusion These insights into TNBC pathogenesis may help guide future therapeutic strategies and improve clinical outcomes for patients with TNBC.https://doi.org/10.1002/cam4.70410classificationdrug resistancegenomic alterationssignaling pathwaystriple‐negative breast cancer |
| spellingShingle | Yuhan Liu Yuhan Zou Yangli Ye Yong Chen Advances in the Understanding of the Pathogenesis of Triple‐Negative Breast Cancer Cancer Medicine classification drug resistance genomic alterations signaling pathways triple‐negative breast cancer |
| title | Advances in the Understanding of the Pathogenesis of Triple‐Negative Breast Cancer |
| title_full | Advances in the Understanding of the Pathogenesis of Triple‐Negative Breast Cancer |
| title_fullStr | Advances in the Understanding of the Pathogenesis of Triple‐Negative Breast Cancer |
| title_full_unstemmed | Advances in the Understanding of the Pathogenesis of Triple‐Negative Breast Cancer |
| title_short | Advances in the Understanding of the Pathogenesis of Triple‐Negative Breast Cancer |
| title_sort | advances in the understanding of the pathogenesis of triple negative breast cancer |
| topic | classification drug resistance genomic alterations signaling pathways triple‐negative breast cancer |
| url | https://doi.org/10.1002/cam4.70410 |
| work_keys_str_mv | AT yuhanliu advancesintheunderstandingofthepathogenesisoftriplenegativebreastcancer AT yuhanzou advancesintheunderstandingofthepathogenesisoftriplenegativebreastcancer AT yangliye advancesintheunderstandingofthepathogenesisoftriplenegativebreastcancer AT yongchen advancesintheunderstandingofthepathogenesisoftriplenegativebreastcancer |