Anti-CV2/CRMP5 autoantibodies as drivers of sensory neuron excitability and pain in rats

Anti-CV2/CRMP5 autoantibodies as drivers of sensory neuron excitability and pain in rats

Abstract Paraneoplastic neurological syndromes arise from autoimmune reactions against nervous system antigens due to a maladaptive immune response to a peripheral cancer. Patients with small cell lung carcinoma or malignant thymoma can develop an autoimmune response against the CV2/collapsin respon...

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Main Authors: Laurent Martin, Harrison J. Stratton, Lyuba Y. Salih, Nicolas LA. Dumaire, Kimberly Gomez, Le Duy Do, Santiago Loya-Lopez, Cheng Tang, Aida Calderon-Rivera, Dongzhi Ran, Venkatrao Nunna, Shreya S. Bellampalli, Liberty François-Moutal, Shizhen Luo, Frank Porreca, Mohab Ibrahim, Véronique Rogemond, Jérôme Honnorat, Rajesh Khanna, Aubin Moutal
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62380-y
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https://doi.org/10.1038/s41467-025-62380-y

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