Plant Mediated Green Synthesis and Antiviral Activity of Gold and Copper Nanoparticles using Malva parviflora L. Leaf Extract
In this study, a facile and eco-friendly method was developed for synthesizing gold and copper nanoparticles (AuNPs and CuNPs) using the ethanolic extract of Malva parviflora L., which acts as a reducer and stabilizer. The leaf ethanolic extract of Malva parviflora L. was prepared using an ultrasoun...
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Iranian Chemical Society
2024-06-01
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| Series: | Nanochemistry Research |
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| Online Access: | http://www.nanochemres.org/article_197060_8b39df332b58efb690fc29706b088411.pdf |
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| author | Seyedeh Raana Charghani Saadat Rastegarzadeh Parzhak Zoufan Seyedeh Elham Rezatofighi |
| author_facet | Seyedeh Raana Charghani Saadat Rastegarzadeh Parzhak Zoufan Seyedeh Elham Rezatofighi |
| author_sort | Seyedeh Raana Charghani |
| collection | DOAJ |
| description | In this study, a facile and eco-friendly method was developed for synthesizing gold and copper nanoparticles (AuNPs and CuNPs) using the ethanolic extract of Malva parviflora L., which acts as a reducer and stabilizer. The leaf ethanolic extract of Malva parviflora L. was prepared using an ultrasound-assisted extraction method. The obtained extract is capable of synthesizing red-purple colored AuNPs and green colored CuNPs at ambient conditions. The characterizations of the nanoparticles were carried out using UV–Vis spectrophotometry, transmission electron microscopy (TEM), particle size analysis (PSA), energy dispersive X-ray (EDX) and zeta potential. The antiviral activity of the compounds was evaluated by measuring the viability of the infected cells by a 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. The TEM images showed that highly dispersed spherical-shaped AuNPs with sizes less than 20 nm and rod-shaped CuNPs with a length of 82 nm and a width of 12 nm were synthesized. The effect of different variables on the biosynthesis and plasmon absorbance of AuNPs and CuNPs was studied. The results indicat that an intensified plasmon absorbance band of AuNPs and CuNPs was observed in alkaline and acidic media, respectively. Although CuNPs have more cytotoxicity than AuNPs, they are more effective at killing viruses. Additionally, ethanolic extract showed significant antiviral activity at non-cytotoxic concentrations. |
| format | Article |
| id | doaj-art-f87d834e0f5f44f98a00ffd5030b7b5f |
| institution | Kabale University |
| issn | 2538-4279 2423-818X |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Iranian Chemical Society |
| record_format | Article |
| series | Nanochemistry Research |
| spelling | doaj-art-f87d834e0f5f44f98a00ffd5030b7b5f2025-01-12T10:25:14ZengIranian Chemical SocietyNanochemistry Research2538-42792423-818X2024-06-019322323410.22036/ncr.2024.03.006197060Plant Mediated Green Synthesis and Antiviral Activity of Gold and Copper Nanoparticles using Malva parviflora L. Leaf ExtractSeyedeh Raana Charghani0Saadat Rastegarzadeh1Parzhak Zoufan2Seyedeh Elham Rezatofighi3Department of Chemistry, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, IranDepartment of Chemistry, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, IranDepartment of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, IranDepartment of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, IranIn this study, a facile and eco-friendly method was developed for synthesizing gold and copper nanoparticles (AuNPs and CuNPs) using the ethanolic extract of Malva parviflora L., which acts as a reducer and stabilizer. The leaf ethanolic extract of Malva parviflora L. was prepared using an ultrasound-assisted extraction method. The obtained extract is capable of synthesizing red-purple colored AuNPs and green colored CuNPs at ambient conditions. The characterizations of the nanoparticles were carried out using UV–Vis spectrophotometry, transmission electron microscopy (TEM), particle size analysis (PSA), energy dispersive X-ray (EDX) and zeta potential. The antiviral activity of the compounds was evaluated by measuring the viability of the infected cells by a 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. The TEM images showed that highly dispersed spherical-shaped AuNPs with sizes less than 20 nm and rod-shaped CuNPs with a length of 82 nm and a width of 12 nm were synthesized. The effect of different variables on the biosynthesis and plasmon absorbance of AuNPs and CuNPs was studied. The results indicat that an intensified plasmon absorbance band of AuNPs and CuNPs was observed in alkaline and acidic media, respectively. Although CuNPs have more cytotoxicity than AuNPs, they are more effective at killing viruses. Additionally, ethanolic extract showed significant antiviral activity at non-cytotoxic concentrations.http://www.nanochemres.org/article_197060_8b39df332b58efb690fc29706b088411.pdfmalva parviflora lbiosynthesisgold nanoparticlescopper nanoparticlesantiviral activity |
| spellingShingle | Seyedeh Raana Charghani Saadat Rastegarzadeh Parzhak Zoufan Seyedeh Elham Rezatofighi Plant Mediated Green Synthesis and Antiviral Activity of Gold and Copper Nanoparticles using Malva parviflora L. Leaf Extract Nanochemistry Research malva parviflora l biosynthesis gold nanoparticles copper nanoparticles antiviral activity |
| title | Plant Mediated Green Synthesis and Antiviral Activity of Gold and Copper Nanoparticles using Malva parviflora L. Leaf Extract |
| title_full | Plant Mediated Green Synthesis and Antiviral Activity of Gold and Copper Nanoparticles using Malva parviflora L. Leaf Extract |
| title_fullStr | Plant Mediated Green Synthesis and Antiviral Activity of Gold and Copper Nanoparticles using Malva parviflora L. Leaf Extract |
| title_full_unstemmed | Plant Mediated Green Synthesis and Antiviral Activity of Gold and Copper Nanoparticles using Malva parviflora L. Leaf Extract |
| title_short | Plant Mediated Green Synthesis and Antiviral Activity of Gold and Copper Nanoparticles using Malva parviflora L. Leaf Extract |
| title_sort | plant mediated green synthesis and antiviral activity of gold and copper nanoparticles using malva parviflora l leaf extract |
| topic | malva parviflora l biosynthesis gold nanoparticles copper nanoparticles antiviral activity |
| url | http://www.nanochemres.org/article_197060_8b39df332b58efb690fc29706b088411.pdf |
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