Biomimetic intelligent nanoplatform with cascade amplification effect for tumor synergy therapy
Abstract Tumor heterogeneity, immune-suppressive microenvironment and the precise killing of tumor cells by drugs are important factors affecting tumor treatment. In this study, we developed environment-responsive drug delivery system (FM@IQ/PST&ZIF-8/DOX) based on ZIF-8 for tumor photothermal/i...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-12-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-82291-0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846101304195153920 |
|---|---|
| author | Ying Wang Qing Ji Chao Yan Pang Ji |
| author_facet | Ying Wang Qing Ji Chao Yan Pang Ji |
| author_sort | Ying Wang |
| collection | DOAJ |
| description | Abstract Tumor heterogeneity, immune-suppressive microenvironment and the precise killing of tumor cells by drugs are important factors affecting tumor treatment. In this study, we developed environment-responsive drug delivery system (FM@IQ/PST&ZIF-8/DOX) based on ZIF-8 for tumor photothermal/immunotherapy/chemotherapy synergistic therapy. The prepared FM@IQ/PST&ZIF-8/DOX nanoplatfrom not only has highly drug loading capacity for chemotherapeutic drug-doxorubicin, but also erythrocyte membrance modified on their surface can endow their immunity-escaping property and prolong their blood circulation time. More important, the neurotransmitter serotonin was encapsulated on the surface of ZIF-8/DOX by oxidative polymerization, which can effectively avoid the premature leakage of DOX in the blood circulation. And the formed polyserotonin shell has superior photothermal conversion performance, as well as the adsorption property of polyserotonin shell was utilized to load imiqumod. When FM@IQ/PST&ZIF-8/DOX entered the tumor tissue, the surface modified folate molecules can specifically bind to the folate receptors on the surface of tumor cells to improve FM@IQ/PST&ZIF-8/DOX uptake by tumor cells. In vitro and in vivo results showed that FM@IQ/PST&ZIF-8/DOX nanoplatform could generate a large amount of heat under near-infrared light irradiation, and then induce the apoptosis of tumor cells, release tumor associated antigens, and effectively solve the problem of tumor heterogeneity. In addition, the loaded imiquimod could effectively improve the immunosuppressive microenvironment, enhance the body’s anti-tumor immune response, to inhibit tumor metastasis and recurrence. Therefore, the novel FM@IQ/PST&ZIF-8/DOX nanoplatform designed in this research can not only achieve controllable and precise drug release, but also it is expected to become a promising new strategy for tumor treatment and provide corresponding inspiration for the later research and development of environment-responsive drugs. |
| format | Article |
| id | doaj-art-f8766e3fa8f64aab98b8a23d818ba4c5 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-f8766e3fa8f64aab98b8a23d818ba4c52024-12-29T12:18:39ZengNature PortfolioScientific Reports2045-23222024-12-0114111610.1038/s41598-024-82291-0Biomimetic intelligent nanoplatform with cascade amplification effect for tumor synergy therapyYing Wang0Qing Ji1Chao Yan2Pang Ji3The Affiliated Huai’an Hospital of Xuzhou Medical University and The Second People’s Hospital of Huai’anDepartment of Clinical Laboratory, The Affiliated People’s Hospital of Jiangsu UniversityThe Affiliated Huai’an Hospital of Xuzhou Medical University and The Second People’s Hospital of Huai’anDepartment of Clinical Laboratory, The Affiliated People’s Hospital of Jiangsu UniversityAbstract Tumor heterogeneity, immune-suppressive microenvironment and the precise killing of tumor cells by drugs are important factors affecting tumor treatment. In this study, we developed environment-responsive drug delivery system (FM@IQ/PST&ZIF-8/DOX) based on ZIF-8 for tumor photothermal/immunotherapy/chemotherapy synergistic therapy. The prepared FM@IQ/PST&ZIF-8/DOX nanoplatfrom not only has highly drug loading capacity for chemotherapeutic drug-doxorubicin, but also erythrocyte membrance modified on their surface can endow their immunity-escaping property and prolong their blood circulation time. More important, the neurotransmitter serotonin was encapsulated on the surface of ZIF-8/DOX by oxidative polymerization, which can effectively avoid the premature leakage of DOX in the blood circulation. And the formed polyserotonin shell has superior photothermal conversion performance, as well as the adsorption property of polyserotonin shell was utilized to load imiqumod. When FM@IQ/PST&ZIF-8/DOX entered the tumor tissue, the surface modified folate molecules can specifically bind to the folate receptors on the surface of tumor cells to improve FM@IQ/PST&ZIF-8/DOX uptake by tumor cells. In vitro and in vivo results showed that FM@IQ/PST&ZIF-8/DOX nanoplatform could generate a large amount of heat under near-infrared light irradiation, and then induce the apoptosis of tumor cells, release tumor associated antigens, and effectively solve the problem of tumor heterogeneity. In addition, the loaded imiquimod could effectively improve the immunosuppressive microenvironment, enhance the body’s anti-tumor immune response, to inhibit tumor metastasis and recurrence. Therefore, the novel FM@IQ/PST&ZIF-8/DOX nanoplatform designed in this research can not only achieve controllable and precise drug release, but also it is expected to become a promising new strategy for tumor treatment and provide corresponding inspiration for the later research and development of environment-responsive drugs.https://doi.org/10.1038/s41598-024-82291-0Tumor heterogeneityEnvironment-responsiveSynergistic therapyPrecise release |
| spellingShingle | Ying Wang Qing Ji Chao Yan Pang Ji Biomimetic intelligent nanoplatform with cascade amplification effect for tumor synergy therapy Scientific Reports Tumor heterogeneity Environment-responsive Synergistic therapy Precise release |
| title | Biomimetic intelligent nanoplatform with cascade amplification effect for tumor synergy therapy |
| title_full | Biomimetic intelligent nanoplatform with cascade amplification effect for tumor synergy therapy |
| title_fullStr | Biomimetic intelligent nanoplatform with cascade amplification effect for tumor synergy therapy |
| title_full_unstemmed | Biomimetic intelligent nanoplatform with cascade amplification effect for tumor synergy therapy |
| title_short | Biomimetic intelligent nanoplatform with cascade amplification effect for tumor synergy therapy |
| title_sort | biomimetic intelligent nanoplatform with cascade amplification effect for tumor synergy therapy |
| topic | Tumor heterogeneity Environment-responsive Synergistic therapy Precise release |
| url | https://doi.org/10.1038/s41598-024-82291-0 |
| work_keys_str_mv | AT yingwang biomimeticintelligentnanoplatformwithcascadeamplificationeffectfortumorsynergytherapy AT qingji biomimeticintelligentnanoplatformwithcascadeamplificationeffectfortumorsynergytherapy AT chaoyan biomimeticintelligentnanoplatformwithcascadeamplificationeffectfortumorsynergytherapy AT pangji biomimeticintelligentnanoplatformwithcascadeamplificationeffectfortumorsynergytherapy |