Body mass index and fat influences the role of Bifidobacterium genus in lupus patients concerning fibrinogen levels
IntroductionMetabolic disorders and autoimmune diseases elicit distinct yet interconnected manifestations of inflammation, which may be boosted by an excess of body adiposity. The purpose of this investigation was to analyze anthropometric, biochemical, and inflammatory/coagulation variables concern...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1471177/full |
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| author | Lourdes Chero-Sandoval Lourdes Chero-Sandoval Andrea Higuera-Gómez Amanda Cuevas-Sierra Amanda Cuevas-Sierra Begoña de Cuevillas Begoña de Cuevillas Raquel Castejón María Martínez-Urbistondo Susana Mellor-Pita Víctor Moreno-Torres Víctor Moreno-Torres Daniel de Luis J. Alfredo Martínez J. Alfredo Martínez J. Alfredo Martínez |
| author_facet | Lourdes Chero-Sandoval Lourdes Chero-Sandoval Andrea Higuera-Gómez Amanda Cuevas-Sierra Amanda Cuevas-Sierra Begoña de Cuevillas Begoña de Cuevillas Raquel Castejón María Martínez-Urbistondo Susana Mellor-Pita Víctor Moreno-Torres Víctor Moreno-Torres Daniel de Luis J. Alfredo Martínez J. Alfredo Martínez J. Alfredo Martínez |
| author_sort | Lourdes Chero-Sandoval |
| collection | DOAJ |
| description | IntroductionMetabolic disorders and autoimmune diseases elicit distinct yet interconnected manifestations of inflammation, which may be boosted by an excess of body adiposity. The purpose of this investigation was to analyze anthropometric, biochemical, and inflammatory/coagulation variables concerning patients diagnosed with systemic lupus erythematosus (SLE) exploiting low-grade metabolic inflammation (MI), as reference.MethodsA population stratification by body mass index (BMI), allowed to assess the impact of adiposity on the putative role of gut microbiota composition on coagulation markers. A total of 127 participants with MI and SLE were categorized into two main groups based on their BMI, following WHO criteria: a low BMI group (<30 kg/m2) and a high BMI group (≥30 kg/m2). Each group included recorded data on demographics, comorbidities, and key clinical markers. Anthropometric and body composition variables, clinical features, and inflammatory/coagulation markers were measured while fecal 16S rRNA sequencing was examined at the genus Bifidobacterium. Regression models were fitted to evaluate the relationship between gut microbiota, inflammatory/coagulation markers, and body weight in these types of diseases.ResultsThe study revealed worse clinical outcomes in anthropometric, body composition, and clinical markers in low-grade MI conditions as compared to SLE. However, inflammatory and coagulation markers such as C-reactive protein (CRP) and fibrinogen were significantly more elevated in patients with SLE, which was exacerbated by high BMI/ body fat as compared to the other screened groups. An interaction analysis revealed that fibrinogen levels showed different trends when Bifidobacterium was increased depending on BMI/adiposity, which evidenced an effect modification by this microorganism in patients with SLE.DiscussionThese findings underline that gut microbiota composition, particularly the presence of Bifidobacterium, may play a crucial role in modulating inflammation and coagulation processes in patients with SLE and high fat. These insights highlight the potential of targeting gut microbiota as a therapeutic strategy to mitigate inflammation and improve clinical outcomes in SLE patients. |
| format | Article |
| id | doaj-art-f86cece2f9da48449c302ad20ddb4d9c |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Microbiology |
| spelling | doaj-art-f86cece2f9da48449c302ad20ddb4d9c2024-11-25T06:23:56ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2024-11-011510.3389/fmicb.2024.14711771471177Body mass index and fat influences the role of Bifidobacterium genus in lupus patients concerning fibrinogen levelsLourdes Chero-Sandoval0Lourdes Chero-Sandoval1Andrea Higuera-Gómez2Amanda Cuevas-Sierra3Amanda Cuevas-Sierra4Begoña de Cuevillas5Begoña de Cuevillas6Raquel Castejón7María Martínez-Urbistondo8Susana Mellor-Pita9Víctor Moreno-Torres10Víctor Moreno-Torres11Daniel de Luis12J. Alfredo Martínez13J. Alfredo Martínez14J. Alfredo Martínez15Precision Nutrition and Cardiometabolic Health, IMDEA-Food Institute (Madrid Institute for Advanced Studies), Campus of International Excellence (CEI) UAM+CSIC, Madrid, SpainDepartment of Endocrinology and Nutrition, University Clinical Hospital, University of Valladolid, Valladolid, SpainPrecision Nutrition and Cardiometabolic Health, IMDEA-Food Institute (Madrid Institute for Advanced Studies), Campus of International Excellence (CEI) UAM+CSIC, Madrid, SpainPrecision Nutrition and Cardiometabolic Health, IMDEA-Food Institute (Madrid Institute for Advanced Studies), Campus of International Excellence (CEI) UAM+CSIC, Madrid, SpainHealth Sciences School and Medical Centre, International University of the Rioja (UNIR), Madrid, SpainPrecision Nutrition and Cardiometabolic Health, IMDEA-Food Institute (Madrid Institute for Advanced Studies), Campus of International Excellence (CEI) UAM+CSIC, Madrid, SpainDepartment of Endocrinology and Nutrition, University Clinical Hospital, University of Valladolid, Valladolid, SpainInternal Medicine Service, Puerta de Hierro Majadahonda University Hospital, Madrid, SpainInternal Medicine Service, Puerta de Hierro Majadahonda University Hospital, Madrid, SpainInternal Medicine Service, Puerta de Hierro Majadahonda University Hospital, Madrid, SpainHealth Sciences School and Medical Centre, International University of the Rioja (UNIR), Madrid, SpainInternal Medicine Service, Puerta de Hierro Majadahonda University Hospital, Madrid, SpainCentre of Endocrinology and Nutrition, University of Valladolid, Valladolid, SpainPrecision Nutrition and Cardiometabolic Health, IMDEA-Food Institute (Madrid Institute for Advanced Studies), Campus of International Excellence (CEI) UAM+CSIC, Madrid, SpainCentre of Endocrinology and Nutrition, University of Valladolid, Valladolid, SpainCIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III (ISCIII), Madrid, SpainIntroductionMetabolic disorders and autoimmune diseases elicit distinct yet interconnected manifestations of inflammation, which may be boosted by an excess of body adiposity. The purpose of this investigation was to analyze anthropometric, biochemical, and inflammatory/coagulation variables concerning patients diagnosed with systemic lupus erythematosus (SLE) exploiting low-grade metabolic inflammation (MI), as reference.MethodsA population stratification by body mass index (BMI), allowed to assess the impact of adiposity on the putative role of gut microbiota composition on coagulation markers. A total of 127 participants with MI and SLE were categorized into two main groups based on their BMI, following WHO criteria: a low BMI group (<30 kg/m2) and a high BMI group (≥30 kg/m2). Each group included recorded data on demographics, comorbidities, and key clinical markers. Anthropometric and body composition variables, clinical features, and inflammatory/coagulation markers were measured while fecal 16S rRNA sequencing was examined at the genus Bifidobacterium. Regression models were fitted to evaluate the relationship between gut microbiota, inflammatory/coagulation markers, and body weight in these types of diseases.ResultsThe study revealed worse clinical outcomes in anthropometric, body composition, and clinical markers in low-grade MI conditions as compared to SLE. However, inflammatory and coagulation markers such as C-reactive protein (CRP) and fibrinogen were significantly more elevated in patients with SLE, which was exacerbated by high BMI/ body fat as compared to the other screened groups. An interaction analysis revealed that fibrinogen levels showed different trends when Bifidobacterium was increased depending on BMI/adiposity, which evidenced an effect modification by this microorganism in patients with SLE.DiscussionThese findings underline that gut microbiota composition, particularly the presence of Bifidobacterium, may play a crucial role in modulating inflammation and coagulation processes in patients with SLE and high fat. These insights highlight the potential of targeting gut microbiota as a therapeutic strategy to mitigate inflammation and improve clinical outcomes in SLE patients.https://www.frontiersin.org/articles/10.3389/fmicb.2024.1471177/fullBifidobacteriumbody mass indexfibrinogenlow-grade metabolic inflammationsystemic lupus erythematosus |
| spellingShingle | Lourdes Chero-Sandoval Lourdes Chero-Sandoval Andrea Higuera-Gómez Amanda Cuevas-Sierra Amanda Cuevas-Sierra Begoña de Cuevillas Begoña de Cuevillas Raquel Castejón María Martínez-Urbistondo Susana Mellor-Pita Víctor Moreno-Torres Víctor Moreno-Torres Daniel de Luis J. Alfredo Martínez J. Alfredo Martínez J. Alfredo Martínez Body mass index and fat influences the role of Bifidobacterium genus in lupus patients concerning fibrinogen levels Frontiers in Microbiology Bifidobacterium body mass index fibrinogen low-grade metabolic inflammation systemic lupus erythematosus |
| title | Body mass index and fat influences the role of Bifidobacterium genus in lupus patients concerning fibrinogen levels |
| title_full | Body mass index and fat influences the role of Bifidobacterium genus in lupus patients concerning fibrinogen levels |
| title_fullStr | Body mass index and fat influences the role of Bifidobacterium genus in lupus patients concerning fibrinogen levels |
| title_full_unstemmed | Body mass index and fat influences the role of Bifidobacterium genus in lupus patients concerning fibrinogen levels |
| title_short | Body mass index and fat influences the role of Bifidobacterium genus in lupus patients concerning fibrinogen levels |
| title_sort | body mass index and fat influences the role of bifidobacterium genus in lupus patients concerning fibrinogen levels |
| topic | Bifidobacterium body mass index fibrinogen low-grade metabolic inflammation systemic lupus erythematosus |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1471177/full |
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