Modelling energy metabolism dysregulations in neuromuscular diseases: A case study of calpainopathy
Biological modelling helps understanding complex processes, like energy metabolism, by predicting pathway compensations and equilibrium under given conditions. When deciphering metabolic adaptations, traditional experiments face challenges due to numerous enzymatic activities, needing modelling to a...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Heliyon |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024169496 |
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| author | Camille Siharath Olivier Biondi Sabine Peres |
| author_facet | Camille Siharath Olivier Biondi Sabine Peres |
| author_sort | Camille Siharath |
| collection | DOAJ |
| description | Biological modelling helps understanding complex processes, like energy metabolism, by predicting pathway compensations and equilibrium under given conditions. When deciphering metabolic adaptations, traditional experiments face challenges due to numerous enzymatic activities, needing modelling to anticipate pathway behaviours and orientate research. This paper aims to implement a constraint-based modelling method of muscular energy metabolism, adaptable to individual situations, energy demands, and complex disease-specific metabolic alterations like muscular dystrophy calpainopathy. Our calpainopathy-like model not only confirms the ATP production defect under increasing energy demands, but suggests compensatory mechanisms through anaerobic glycolysis. However, excessive glycolysis indicates a need to enhance mitochondrial respiration, preventing excess lactate production common in several diseases. Our model suggests that moderate-intensity physiotherapy, known to improve aerobic performance and anaerobic buffering, combined with increased carbohydrate and amino acid sources, could be a potent therapeutic approach for calpainopathy. |
| format | Article |
| id | doaj-art-f84c3d0757d74508aabb11b3a7a4f658 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-f84c3d0757d74508aabb11b3a7a4f6582024-12-19T10:56:10ZengElsevierHeliyon2405-84402024-12-011024e40918Modelling energy metabolism dysregulations in neuromuscular diseases: A case study of calpainopathyCamille Siharath0Olivier Biondi1Sabine Peres2Laboratoire de Biométrie et de Biologie Évolutive, UMR CNRS 5558 Université Claude Bernard Lyon 1, 69622, Villeurbanne cedex, France; ERABLE, INRIA Lyon Centre, 69622, Villeurbanne cedex, FranceLaboratoire de Biologie de l'Exercice pour la Performance et la Santé (LBEPS), UMR, Université d'Evry, IRBA, Université de Paris Saclay, 91025, Evry-Courcouronnes, FranceLaboratoire de Biométrie et de Biologie Évolutive, UMR CNRS 5558 Université Claude Bernard Lyon 1, 69622, Villeurbanne cedex, France; ERABLE, INRIA Lyon Centre, 69622, Villeurbanne cedex, France; Corresponding author.Biological modelling helps understanding complex processes, like energy metabolism, by predicting pathway compensations and equilibrium under given conditions. When deciphering metabolic adaptations, traditional experiments face challenges due to numerous enzymatic activities, needing modelling to anticipate pathway behaviours and orientate research. This paper aims to implement a constraint-based modelling method of muscular energy metabolism, adaptable to individual situations, energy demands, and complex disease-specific metabolic alterations like muscular dystrophy calpainopathy. Our calpainopathy-like model not only confirms the ATP production defect under increasing energy demands, but suggests compensatory mechanisms through anaerobic glycolysis. However, excessive glycolysis indicates a need to enhance mitochondrial respiration, preventing excess lactate production common in several diseases. Our model suggests that moderate-intensity physiotherapy, known to improve aerobic performance and anaerobic buffering, combined with increased carbohydrate and amino acid sources, could be a potent therapeutic approach for calpainopathy.http://www.sciencedirect.com/science/article/pii/S2405844024169496 |
| spellingShingle | Camille Siharath Olivier Biondi Sabine Peres Modelling energy metabolism dysregulations in neuromuscular diseases: A case study of calpainopathy Heliyon |
| title | Modelling energy metabolism dysregulations in neuromuscular diseases: A case study of calpainopathy |
| title_full | Modelling energy metabolism dysregulations in neuromuscular diseases: A case study of calpainopathy |
| title_fullStr | Modelling energy metabolism dysregulations in neuromuscular diseases: A case study of calpainopathy |
| title_full_unstemmed | Modelling energy metabolism dysregulations in neuromuscular diseases: A case study of calpainopathy |
| title_short | Modelling energy metabolism dysregulations in neuromuscular diseases: A case study of calpainopathy |
| title_sort | modelling energy metabolism dysregulations in neuromuscular diseases a case study of calpainopathy |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024169496 |
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