Sucla2 Knock‐Out in Skeletal Muscle Yields Mouse Model of Mitochondrial Myopathy With Muscle Type–Specific Phenotypes

Sucla2 Knock‐Out in Skeletal Muscle Yields Mouse Model of Mitochondrial Myopathy With Muscle Type–Specific Phenotypes

ABSTRACT Background Pathogenic variants in subunits of succinyl‐CoA synthetase (SCS) are associated with mitochondrial encephalomyopathy in humans. SCS catalyses the conversion of succinyl‐CoA to succinate coupled with substrate‐level phosphorylation of either ADP or GDP in the TCA cycle. This repor...

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Bibliographic Details
Main Authors: Makayla S. Lancaster, Paul Hafen, Andrew S. Law, Catalina Matias, Timothy Meyer, Kathryn Fischer, Marcus Miller, Chunhai Hao, Patrick Gillespie, David McKinzie, Jeffrey J. Brault, Brett H. Graham
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
contractility
extensor digitorum longus
fibre‐type switching
mitochondrial myopathy
soleus
succinyl‐CoA synthetase
Online Access:https://doi.org/10.1002/jcsm.13617
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