The chiisanoside derivatives present in the leaves of Acanthopanax sessiliflorus activate autophagy through the LRP6/GSK3β axis and thereafter inhibit oxidative stress, thereby counteracting cisplatin-induced ototoxicity

The chiisanoside derivatives present in the leaves of Acanthopanax sessiliflorus activate autophagy through the LRP6/GSK3β axis and thereafter inhibit oxidative stress, thereby counteracting cisplatin-induced ototoxicity

IntroductionCisplatin is extensively employed in the treatment of multiple solid malignant tumors. Nevertheless, side effects such as cisplatin-induced ototoxicity (CIO) pose obstacles to tumor therapy.The important natural product chiisanoside from Acanthopanax sessiliflorus has abundant activity a...

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Bibliographic Details
Main Authors: Wenxin Zhang, Hongbo Teng, Tianyi Zhao, Roberts I. Eglitis, Xv Wang, Zhengxuan Yu, Shurong Qu, Haijing Wang, Yaru Zhao, Bowen Fan, Shuangli Liu, Yan Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
cisplatin-induced ototoxicity (CIO)
RNA sequencing
autophagy
oxidative stress
chiisanoside derivatives
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1518810/full
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